Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896631236> ?p ?o ?g. }
- W2896631236 abstract "Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as the lifespan-extending gene, silent information regulator 2 (SIRT2) in budding yeast. There are seven mammalian homologs of sirtuin (SIRT1-7), and SIRT1 is the closest homolog to SIRT2. SIRT1 modulates various key targets via deacetylation. In addition to histones, these targets include transcription factors, such as forkhead box O (FOXO), Ku70, p53, NF-κB, PPAR-gamma co-activator 1-alpha (PGC-1α), and peroxisome proliferator-activated receptor γ (PPARγ). SIRT1 has many biological functions, including aging, cell survival, differentiation, and metabolism. Genetic and physiological analyses in animal models have shown beneficial roles for SIRT1 in the brain during both development and adulthood. Evidence from in vivo and in vitro studies have revealed that SIRT1 regulates the cellular fate of neural progenitors, axon elongation, dendritic branching, synaptic plasticity, and endocrine function. In addition to its importance in physiological processes, SIRT1 has also been implicated in protection of neurons from degeneration in models of neurological diseases, such as traumatic brain injury and Alzheimer's disease. In this review, we focus on the role of SIRT1 in the neuroendocrine system and neurodegenerative diseases. We also discuss the potential therapeutic implications of targeting the sirtuin pathway." @default.
- W2896631236 created "2018-10-26" @default.
- W2896631236 creator A5043263625 @default.
- W2896631236 creator A5076608744 @default.
- W2896631236 date "2018-10-26" @default.
- W2896631236 modified "2023-10-14" @default.
- W2896631236 title "Sirtuins in Neuroendocrine Regulation and Neurological Diseases" @default.
- W2896631236 cites W1488128045 @default.
- W2896631236 cites W1495117058 @default.
- W2896631236 cites W1510213348 @default.
- W2896631236 cites W1519075624 @default.
- W2896631236 cites W1553938284 @default.
- W2896631236 cites W1561443084 @default.
- W2896631236 cites W1594575326 @default.
- W2896631236 cites W1619082318 @default.
- W2896631236 cites W1627352250 @default.
- W2896631236 cites W1886477676 @default.
- W2896631236 cites W1898670638 @default.
- W2896631236 cites W1926757795 @default.
- W2896631236 cites W1964059126 @default.
- W2896631236 cites W1964374986 @default.
- W2896631236 cites W1964455116 @default.
- W2896631236 cites W1965296401 @default.
- W2896631236 cites W1970753300 @default.
- W2896631236 cites W1971070284 @default.
- W2896631236 cites W1971925893 @default.
- W2896631236 cites W1972262497 @default.
- W2896631236 cites W1973083723 @default.
- W2896631236 cites W1974172728 @default.
- W2896631236 cites W1974291607 @default.
- W2896631236 cites W1974529717 @default.
- W2896631236 cites W1975022774 @default.
- W2896631236 cites W1975304724 @default.
- W2896631236 cites W1978566481 @default.
- W2896631236 cites W1979039549 @default.
- W2896631236 cites W1980288154 @default.
- W2896631236 cites W1981073919 @default.
- W2896631236 cites W1982441939 @default.
- W2896631236 cites W1983523416 @default.
- W2896631236 cites W1984308009 @default.
- W2896631236 cites W1984616391 @default.
- W2896631236 cites W1984917111 @default.
- W2896631236 cites W1986238583 @default.
- W2896631236 cites W1986478574 @default.
- W2896631236 cites W1989164058 @default.
- W2896631236 cites W1989407684 @default.
- W2896631236 cites W1989674299 @default.
- W2896631236 cites W1991017805 @default.
- W2896631236 cites W1991660337 @default.
- W2896631236 cites W1992191761 @default.
- W2896631236 cites W1992371392 @default.
- W2896631236 cites W1992538179 @default.
- W2896631236 cites W1992913613 @default.
- W2896631236 cites W1996094302 @default.
- W2896631236 cites W1998000193 @default.
- W2896631236 cites W1998019353 @default.
- W2896631236 cites W1999342511 @default.
- W2896631236 cites W2000437193 @default.
- W2896631236 cites W2001457226 @default.
- W2896631236 cites W2002811789 @default.
- W2896631236 cites W2003388226 @default.
- W2896631236 cites W2003618511 @default.
- W2896631236 cites W2004127466 @default.
- W2896631236 cites W2004476854 @default.
- W2896631236 cites W2006173503 @default.
- W2896631236 cites W2006546979 @default.
- W2896631236 cites W2008376603 @default.
- W2896631236 cites W2012753961 @default.
- W2896631236 cites W2013139068 @default.
- W2896631236 cites W2013551511 @default.
- W2896631236 cites W2018492629 @default.
- W2896631236 cites W2018675431 @default.
- W2896631236 cites W2019256890 @default.
- W2896631236 cites W2019656833 @default.
- W2896631236 cites W2020311873 @default.
- W2896631236 cites W2022593257 @default.
- W2896631236 cites W2023836268 @default.
- W2896631236 cites W2025084955 @default.
- W2896631236 cites W2025206704 @default.
- W2896631236 cites W2026136759 @default.
- W2896631236 cites W2026393786 @default.
- W2896631236 cites W2027344089 @default.
- W2896631236 cites W2028178274 @default.
- W2896631236 cites W2028221290 @default.
- W2896631236 cites W2029997359 @default.
- W2896631236 cites W2030366098 @default.
- W2896631236 cites W2031964319 @default.
- W2896631236 cites W2034451927 @default.
- W2896631236 cites W2039017765 @default.
- W2896631236 cites W2039451247 @default.
- W2896631236 cites W2040462263 @default.
- W2896631236 cites W2041749675 @default.
- W2896631236 cites W2042991032 @default.
- W2896631236 cites W2043033966 @default.
- W2896631236 cites W2043214240 @default.
- W2896631236 cites W2045337251 @default.
- W2896631236 cites W2049905319 @default.
- W2896631236 cites W2051179150 @default.
- W2896631236 cites W2051634868 @default.
- W2896631236 cites W2051752226 @default.