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• W2896631314 abstract "Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels." @default.
• W2896631314 created "2018-10-26" @default.
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• W2896631314 date "2018-10-11" @default.
• W2896631314 modified "2023-10-18" @default.
• W2896631314 title "Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?" @default.
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• W2896631314 doi "https://doi.org/10.1080/15548627.2018.1530929" @default.
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