Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896633263> ?p ?o ?g. }
- W2896633263 endingPage "11029" @default.
- W2896633263 startingPage "11024" @default.
- W2896633263 abstract "Significance R loops form during transcription when the mRNA hybridizes back to the template DNA forming a stable DNA–RNA hybrid. Stable R loops can block replication and transcription machineries, leading to genome instability and human diseases. We report that the human mitochondrial degradosome (mtEXO), formed by SUV3 and PNPase, plays an important role in R-loop metabolism in the mitochondria apart from preventing dsRNA accumulation, with implications in replication and preventing instability of the mitochondrial genome. Our findings help establish a connection between the RNA processing activities of the mtEXO and mitochondrial genome stability, affecting mitochondria homeostasis, cellular metabolism, and human diseases." @default.
- W2896633263 created "2018-10-26" @default.
- W2896633263 creator A5043281613 @default.
- W2896633263 creator A5043991035 @default.
- W2896633263 creator A5069019571 @default.
- W2896633263 date "2018-10-09" @default.
- W2896633263 modified "2023-10-15" @default.
- W2896633263 title "Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability" @default.
- W2896633263 cites W1557728494 @default.
- W2896633263 cites W1618483981 @default.
- W2896633263 cites W1635346580 @default.
- W2896633263 cites W1907337082 @default.
- W2896633263 cites W1913284131 @default.
- W2896633263 cites W1916496494 @default.
- W2896633263 cites W1965425611 @default.
- W2896633263 cites W1966953154 @default.
- W2896633263 cites W1967706132 @default.
- W2896633263 cites W1968789240 @default.
- W2896633263 cites W1969625755 @default.
- W2896633263 cites W1972011626 @default.
- W2896633263 cites W1975993845 @default.
- W2896633263 cites W2011073385 @default.
- W2896633263 cites W2011813312 @default.
- W2896633263 cites W2011873740 @default.
- W2896633263 cites W2019009414 @default.
- W2896633263 cites W2023233842 @default.
- W2896633263 cites W2028767896 @default.
- W2896633263 cites W2031665897 @default.
- W2896633263 cites W2033054103 @default.
- W2896633263 cites W2038809659 @default.
- W2896633263 cites W2040569030 @default.
- W2896633263 cites W2043375872 @default.
- W2896633263 cites W2048103232 @default.
- W2896633263 cites W2059453176 @default.
- W2896633263 cites W2063136478 @default.
- W2896633263 cites W2071073535 @default.
- W2896633263 cites W2079887959 @default.
- W2896633263 cites W2088635998 @default.
- W2896633263 cites W2098981111 @default.
- W2896633263 cites W2100702807 @default.
- W2896633263 cites W2106139526 @default.
- W2896633263 cites W2112007399 @default.
- W2896633263 cites W2121647638 @default.
- W2896633263 cites W2131110198 @default.
- W2896633263 cites W2134432583 @default.
- W2896633263 cites W2143309533 @default.
- W2896633263 cites W2143406467 @default.
- W2896633263 cites W2150368381 @default.
- W2896633263 cites W2154990937 @default.
- W2896633263 cites W2166434010 @default.
- W2896633263 cites W2167279371 @default.
- W2896633263 cites W2168716855 @default.
- W2896633263 cites W2168754435 @default.
- W2896633263 cites W2171525715 @default.
- W2896633263 cites W2207325914 @default.
- W2896633263 cites W2281827817 @default.
- W2896633263 cites W2340421620 @default.
- W2896633263 cites W2423627688 @default.
- W2896633263 cites W2463555142 @default.
- W2896633263 cites W2475966948 @default.
- W2896633263 cites W2500686989 @default.
- W2896633263 cites W2508320436 @default.
- W2896633263 cites W2568405599 @default.
- W2896633263 cites W2605465471 @default.
- W2896633263 cites W2611738474 @default.
- W2896633263 cites W2620855781 @default.
- W2896633263 cites W2750614384 @default.
- W2896633263 cites W2765204989 @default.
- W2896633263 cites W2766758135 @default.
- W2896633263 cites W2798187866 @default.
- W2896633263 cites W2883018577 @default.
- W2896633263 cites W2952759709 @default.
- W2896633263 doi "https://doi.org/10.1073/pnas.1807258115" @default.
- W2896633263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205488" @default.
- W2896633263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301808" @default.
- W2896633263 hasPublicationYear "2018" @default.
- W2896633263 type Work @default.
- W2896633263 sameAs 2896633263 @default.
- W2896633263 citedByCount "62" @default.
- W2896633263 countsByYear W28966332632018 @default.
- W2896633263 countsByYear W28966332632019 @default.
- W2896633263 countsByYear W28966332632020 @default.
- W2896633263 countsByYear W28966332632021 @default.
- W2896633263 countsByYear W28966332632022 @default.
- W2896633263 countsByYear W28966332632023 @default.
- W2896633263 crossrefType "journal-article" @default.
- W2896633263 hasAuthorship W2896633263A5043281613 @default.
- W2896633263 hasAuthorship W2896633263A5043991035 @default.
- W2896633263 hasAuthorship W2896633263A5069019571 @default.
- W2896633263 hasBestOaLocation W28966332631 @default.
- W2896633263 hasConcept C104317684 @default.
- W2896633263 hasConcept C138885662 @default.
- W2896633263 hasConcept C141231307 @default.
- W2896633263 hasConcept C143425029 @default.
- W2896633263 hasConcept C151994961 @default.
- W2896633263 hasConcept C178169997 @default.
- W2896633263 hasConcept C179926584 @default.
- W2896633263 hasConcept C197077220 @default.