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- W2896633866 abstract "Over the past decade, genomic and transcriptomic analyses have uncovered promising tumor antigens including immunotherapeutic targets in bladder cancer (BCa). Conventional tumor antigens are proteins expressed on the plasma membrane of tumor cells such as EGFR, FGFR3, and ERBB2 in BCa, which can be targeted by antibodies or similar epitope-specific binding reagents. The cellular proteome consists of ∼100,000 proteins but the expression of these proteins is rarely unique to tumor cells. Many tumor-associated proteins are post-translationally modified with phosphorylation, glycosylation, ubiquitination, or SUMOylation moieties. Although these modifications expand the complexity, they potentially offer novel targeting opportunities across tumor sub-populations. Experimental targeting of cancer-specific post-translational modifications (PTMs) has shown encouraging results in pre-clinical models of BCa, which could potentially overcome issues with inherent intra-tumor heterogeneity due to simultaneous expression on different proteins. Here, we review current knowledge on post-translational modifications in BCa and highlight recent efforts in experimental targeting strategies." @default.
- W2896633866 created "2018-10-26" @default.
- W2896633866 creator A5048290629 @default.
- W2896633866 creator A5050196540 @default.
- W2896633866 creator A5051781768 @default.
- W2896633866 creator A5081746672 @default.
- W2896633866 date "2020-12-01" @default.
- W2896633866 modified "2023-10-01" @default.
- W2896633866 title "Post-translational modifications in bladder cancer: Expanding the tumor target repertoire" @default.
- W2896633866 cites W1182461782 @default.
- W2896633866 cites W1830980872 @default.
- W2896633866 cites W1831338607 @default.
- W2896633866 cites W1894363324 @default.
- W2896633866 cites W1898194260 @default.
- W2896633866 cites W1964905854 @default.
- W2896633866 cites W1974515407 @default.
- W2896633866 cites W1975701041 @default.
- W2896633866 cites W1975729230 @default.
- W2896633866 cites W1977696467 @default.
- W2896633866 cites W1985995600 @default.
- W2896633866 cites W1987496015 @default.
- W2896633866 cites W1987531089 @default.
- W2896633866 cites W1991173066 @default.
- W2896633866 cites W1992520653 @default.
- W2896633866 cites W1993747943 @default.
- W2896633866 cites W1996811697 @default.
- W2896633866 cites W1999920891 @default.
- W2896633866 cites W2001761736 @default.
- W2896633866 cites W2005739512 @default.
- W2896633866 cites W2006603416 @default.
- W2896633866 cites W2008545486 @default.
- W2896633866 cites W2008782229 @default.
- W2896633866 cites W2009640362 @default.
- W2896633866 cites W2010451992 @default.
- W2896633866 cites W2022534648 @default.
- W2896633866 cites W2023096047 @default.
- W2896633866 cites W2024885145 @default.
- W2896633866 cites W2025672055 @default.
- W2896633866 cites W2026626439 @default.
- W2896633866 cites W2030736292 @default.
- W2896633866 cites W2033047611 @default.
- W2896633866 cites W2045840829 @default.
- W2896633866 cites W2050748595 @default.
- W2896633866 cites W2054374698 @default.
- W2896633866 cites W2054590983 @default.
- W2896633866 cites W2056681809 @default.
- W2896633866 cites W2065136679 @default.
- W2896633866 cites W2066713051 @default.
- W2896633866 cites W2066793047 @default.
- W2896633866 cites W2085245164 @default.
- W2896633866 cites W2085324134 @default.
- W2896633866 cites W2091091775 @default.
- W2896633866 cites W2091324427 @default.
- W2896633866 cites W2093893930 @default.
- W2896633866 cites W2094746964 @default.
- W2896633866 cites W2098806204 @default.
- W2896633866 cites W2103174201 @default.
- W2896633866 cites W2103725052 @default.
- W2896633866 cites W2103946207 @default.
- W2896633866 cites W2105069636 @default.
- W2896633866 cites W2107731724 @default.
- W2896633866 cites W2113156769 @default.
- W2896633866 cites W2122509620 @default.
- W2896633866 cites W2122608403 @default.
- W2896633866 cites W2124775559 @default.
- W2896633866 cites W2128699830 @default.
- W2896633866 cites W2128846014 @default.
- W2896633866 cites W2130560835 @default.
- W2896633866 cites W2136940817 @default.
- W2896633866 cites W2147036069 @default.
- W2896633866 cites W2151801593 @default.
- W2896633866 cites W2157607726 @default.
- W2896633866 cites W2160938666 @default.
- W2896633866 cites W2162024486 @default.
- W2896633866 cites W2165886816 @default.
- W2896633866 cites W2166987747 @default.
- W2896633866 cites W2169882667 @default.
- W2896633866 cites W2173598215 @default.
- W2896633866 cites W2174280833 @default.
- W2896633866 cites W2176744910 @default.
- W2896633866 cites W2205194111 @default.
- W2896633866 cites W2222502154 @default.
- W2896633866 cites W2233600556 @default.
- W2896633866 cites W2267059217 @default.
- W2896633866 cites W2309366384 @default.
- W2896633866 cites W2346413079 @default.
- W2896633866 cites W2347136435 @default.
- W2896633866 cites W2405344993 @default.
- W2896633866 cites W2431163235 @default.
- W2896633866 cites W2516276209 @default.
- W2896633866 cites W2516991121 @default.
- W2896633866 cites W2522355464 @default.
- W2896633866 cites W2559804019 @default.
- W2896633866 cites W2581684929 @default.
- W2896633866 cites W2587529582 @default.
- W2896633866 cites W2588916311 @default.
- W2896633866 cites W2601092243 @default.
- W2896633866 cites W2607115439 @default.