FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896640496> ?p ?o ?g. }

• W2896640496 endingPage "34918" @default.
• W2896640496 startingPage "34911" @default.
• W2896640496 abstract "// Laura Bertoccini 1 , Diego Bailetti 1 , SUMMER Study in Diabetes Group * , Raffaella Buzzetti 1 , Maria Gisella Cavallo 1 , Massimiliano Copetti 2 , Efisio Cossu 3 , Paola D'Angelo 4 , Salvatore De Cosmo 5 , Lazzaro Di Mauro 6 , Frida Leonetti 1 , Susanna Morano 1 , Lelio Morviducci 7 , Nicola Napoli 8 , Sabrina Prudente 9 , Giuseppe Pugliese 10 , Vincenzo Trischitta 1, 9 and Marco Giorgio Baroni 1 1 Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy 2 Unit of Biostatistics, IRCSS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy 3 Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy 4 Unit of Diabetology, Sandro Pertini Hospital, Rome, Italy 5 IRCSS Casa Sollievo della Sofferenza, Department of Medicine, San Giovanni Rotondo, Italy 6 Laboratory of Clinical Chemistry, IRCSS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy 7 Unit of Diabetology, S. Spirito Hospital – AslRM1, Rome, Italy 8 Campus Biomedico University, Rome, Italy 9 IRCCS Casa Sollievo della Sofferenza, Research Unit of Metabolic and Cardiovascular Diseases, San Giovanni Rotondo, Italy 10 Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy * The Investigators of the “Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes” Study Group are: Elena Alessi 10 , Francesco Bagella 1 , Ilaria Barchetta 1 , Danila Capoccia 1 , Silvia Carletti 4 , Federica Coccia 1 , Francesco Conti 9 , Luca D'Onofrio 1 , Tiziana Filardi 1 , Giulia Leanza 8 , Gianluca Margiotta 1 , Michela Incani 3 , Chiara Moretti 1 , Serena Pezzilli 9 , Carlotta Pibiri 1 , Pamela Piscitelli 5 , Maria Giovanna Scarale 2 , Federica Sentinelli 1 , Federica Tavaglione 1 Correspondence to: Marco Giorgio Baroni, email: marco.baroni@uniroma1.it Keywords: genetic risk score; DHCR7 (7-dehydrocholesterol reductase); CYP2R1 (Cytochrome P450 Family 2 Subfamily R Member 1); GC (Vitamin D Binding Protein); SUMMER Study in Diabetes Received: July 18, 2018      Accepted: September 17, 2018      Published: October 09, 2018 ABSTRACT Mortality rate is increased in type 2 diabetes (T2D). Low vitamin D levels are associated with increased mortality risk in T2D. In the general population, genetic variants affecting vitamin D metabolism ( DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the “Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes”. Measurements of serum vitamin D were centralised. Genotypes were obtained by Eco™ Real-Time PCR. Data were adjusted for gender, age, BMI, HbA1c, T2D therapy and sampling season. DHCR7 rs12785878 ( p = 1 x 10 –4 ) and GC rs4588 ( p = 1 x 10 –6 ) but not CYP2R1 rs10741657 ( p = 0.31) were significantly associated with vitamin D levels. One unit of a weighted genotype risk score (GRS) was strongly associated with vitamin D levels ( p = 1.1 x 10 –11 ) and insufficiency (<30 ng/ml) (OR, 95%CI = 1.28, 1.16–1.41, p = 1.1 x 10 –7 ). In conclusion, DHCR7 rs12785878 and GC rs4588, but not CYP2R1 rs10741657, are significantly associated with vitamin D levels. When the 3 variants were considered together as GRS, a strong association with vitamin D levels and vitamin D insufficiency was observed, thus providing robust evidence that genes involved in vitamin D metabolism modulate serum vitamin D in T2D." @default.
• W2896640496 created "2018-10-26" @default.
• W2896640496 creator A5002179851 @default.
• W2896640496 creator A5002905256 @default.
• W2896640496 creator A5005627527 @default.
• W2896640496 creator A5009142969 @default.
• W2896640496 creator A5011695235 @default.
• W2896640496 creator A5016239812 @default.
• W2896640496 creator A5023676579 @default.
• W2896640496 creator A5032911596 @default.
• W2896640496 creator A5035567886 @default.
• W2896640496 creator A5041892243 @default.
• W2896640496 creator A5057527058 @default.
• W2896640496 creator A5058930058 @default.
• W2896640496 creator A5067754036 @default.
• W2896640496 creator A5076684145 @default.
• W2896640496 creator A5079278441 @default.
• W2896640496 creator A5082248255 @default.
• W2896640496 creator A5088051605 @default.
• W2896640496 date "2018-10-09" @default.
• W2896640496 modified "2023-10-02" @default.
• W2896640496 title "Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes" @default.
• W2896640496 cites W1848824835 @default.
• W2896640496 cites W1896055237 @default.
• W2896640496 cites W1964390696 @default.
• W2896640496 cites W2011725731 @default.
• W2896640496 cites W2011936979 @default.
• W2896640496 cites W2014352894 @default.
• W2896640496 cites W2044310665 @default.
• W2896640496 cites W2078707887 @default.
• W2896640496 cites W2079789436 @default.
• W2896640496 cites W2090228791 @default.
• W2896640496 cites W2091637200 @default.
• W2896640496 cites W2097489176 @default.
• W2896640496 cites W2099144303 @default.
• W2896640496 cites W2103783427 @default.
• W2896640496 cites W2104824557 @default.
• W2896640496 cites W2113603970 @default.
• W2896640496 cites W2114217792 @default.
• W2896640496 cites W2126919962 @default.
• W2896640496 cites W2131967882 @default.
• W2896640496 cites W2133936492 @default.
• W2896640496 cites W2135487574 @default.
• W2896640496 cites W2146159982 @default.
• W2896640496 cites W2147466732 @default.
• W2896640496 cites W2149734034 @default.
• W2896640496 cites W2150274025 @default.
• W2896640496 cites W2152795085 @default.
• W2896640496 cites W2154639033 @default.
• W2896640496 cites W2155216078 @default.
• W2896640496 cites W2156810420 @default.
• W2896640496 cites W2162258804 @default.
• W2896640496 cites W2168765940 @default.
• W2896640496 cites W2171816167 @default.
• W2896640496 cites W2347083470 @default.
• W2896640496 cites W2519140039 @default.
• W2896640496 cites W2588906490 @default.
• W2896640496 cites W2783489228 @default.
• W2896640496 cites W2801709424 @default.
• W2896640496 doi "https://doi.org/10.18632/oncotarget.26178" @default.
• W2896640496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6201852" @default.
• W2896640496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405883" @default.
• W2896640496 hasPublicationYear "2018" @default.
• W2896640496 type Work @default.
• W2896640496 sameAs 2896640496 @default.
• W2896640496 citedByCount "4" @default.
• W2896640496 countsByYear W28966404962019 @default.
• W2896640496 countsByYear W28966404962020 @default.
• W2896640496 countsByYear W28966404962021 @default.
• W2896640496 crossrefType "journal-article" @default.
• W2896640496 hasAuthorship W2896640496A5002179851 @default.
• W2896640496 hasAuthorship W2896640496A5002905256 @default.
• W2896640496 hasAuthorship W2896640496A5005627527 @default.
• W2896640496 hasAuthorship W2896640496A5009142969 @default.
• W2896640496 hasAuthorship W2896640496A5011695235 @default.
• W2896640496 hasAuthorship W2896640496A5016239812 @default.
• W2896640496 hasAuthorship W2896640496A5023676579 @default.
• W2896640496 hasAuthorship W2896640496A5032911596 @default.
• W2896640496 hasAuthorship W2896640496A5035567886 @default.
• W2896640496 hasAuthorship W2896640496A5041892243 @default.
• W2896640496 hasAuthorship W2896640496A5057527058 @default.
• W2896640496 hasAuthorship W2896640496A5058930058 @default.
• W2896640496 hasAuthorship W2896640496A5067754036 @default.
• W2896640496 hasAuthorship W2896640496A5076684145 @default.
• W2896640496 hasAuthorship W2896640496A5079278441 @default.
• W2896640496 hasAuthorship W2896640496A5082248255 @default.
• W2896640496 hasAuthorship W2896640496A5088051605 @default.
• W2896640496 hasBestOaLocation W28966404961 @default.
• W2896640496 hasConcept C134018914 @default.
• W2896640496 hasConcept C2779851975 @default.
• W2896640496 hasConcept C555293320 @default.
• W2896640496 hasConcept C71924100 @default.
• W2896640496 hasConceptScore W2896640496C134018914 @default.
• W2896640496 hasConceptScore W2896640496C2779851975 @default.
• W2896640496 hasConceptScore W2896640496C555293320 @default.
• W2896640496 hasConceptScore W2896640496C71924100 @default.
• W2896640496 hasIssue "79" @default.
• W2896640496 hasLocation W28966404961 @default.

• next