FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896640994> ?p ?o ?g. }

• W2896640994 endingPage "e1526613" @default.
• W2896640994 startingPage "e1526613" @default.
• W2896640994 abstract "Harnessing the immune system by checkpoint blockade has greatly expanded the therapeutic options for advanced cancer. Since the efficacy of immunotherapies is influenced by the molecular make-up of the tumor and its crosstalk with the immune system, comprehensive analysis of genetic and immunologic tumor characteristics is essential to gain insight into mechanisms of therapy response and resistance. We investigated the association of immune cell contexture and tumor genetics including tumor mutational burden (TMB), copy number alteration (CNA) load, mutant allele heterogeneity (MATH) and specific mutational signatures (MutSigs) using TCGA data of 5722 tumor samples from 21 cancer types. Among all genetic variables, MutSigs associated with DNA repair deficiency and AID/APOBEC gene activity showed the strongest positive correlations with immune parameters. For smoking-related and UV-light-exposure associated MutSigs a few positive correlations were identified, while MutSig 1 (clock-like process) correlated non-significantly or negatively with the major immune parameters in most cancer types. High TMB was associated with high immune cell infiltrates in some but not all cancer types, in contrast, high CNA load and high MATH were mostly associated with low immune cell infiltrates. While a bi- or multimodal distribution of TMB was observed in colorectal, stomach and endometrial cancer where its levels were associated with POLE/POLD1 mutations and MSI status, TMB was unimodal distributed in the most other cancer types including NSCLC and melanoma. In summary, this study uncovered specific genetic-immunology associations in major cancer types and suggests that mutational signatures should be further investigated as interesting candidates for response prediction beyond TMB." @default.
• W2896640994 created "2018-10-26" @default.
• W2896640994 creator A5018231423 @default.
• W2896640994 creator A5019845586 @default.
• W2896640994 creator A5023340072 @default.
• W2896640994 creator A5026607584 @default.
• W2896640994 creator A5029462216 @default.
• W2896640994 creator A5033698551 @default.
• W2896640994 creator A5072724582 @default.
• W2896640994 creator A5079885079 @default.
• W2896640994 creator A5081978650 @default.
• W2896640994 creator A5089035898 @default.
• W2896640994 date "2018-10-19" @default.
• W2896640994 modified "2023-10-16" @default.
• W2896640994 title "Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burden" @default.
• W2896640994 cites W1498562444 @default.
• W2896640994 cites W1499993276 @default.
• W2896640994 cites W1976078521 @default.
• W2896640994 cites W1985987855 @default.
• W2896640994 cites W2011458181 @default.
• W2896640994 cites W2028144930 @default.
• W2896640994 cites W2028433016 @default.
• W2896640994 cites W2049553585 @default.
• W2896640994 cites W2066671159 @default.
• W2896640994 cites W2082158071 @default.
• W2896640994 cites W2099471884 @default.
• W2896640994 cites W2122989279 @default.
• W2896640994 cites W2136859769 @default.
• W2896640994 cites W2152061559 @default.
• W2896640994 cites W2173818354 @default.
• W2896640994 cites W2289712604 @default.
• W2896640994 cites W2291298003 @default.
• W2896640994 cites W2308639964 @default.
• W2896640994 cites W2344049231 @default.
• W2896640994 cites W2465142962 @default.
• W2896640994 cites W2465860350 @default.
• W2896640994 cites W2471873673 @default.
• W2896640994 cites W2533508881 @default.
• W2896640994 cites W2547187744 @default.
• W2896640994 cites W2574604975 @default.
• W2896640994 cites W2578528809 @default.
• W2896640994 cites W2582242752 @default.
• W2896640994 cites W2594102731 @default.
• W2896640994 cites W2610241918 @default.
• W2896640994 cites W2622499649 @default.
• W2896640994 cites W2635951006 @default.
• W2896640994 cites W2725398806 @default.
• W2896640994 cites W2742116257 @default.
• W2896640994 cites W2750667003 @default.
• W2896640994 cites W2762818553 @default.
• W2896640994 cites W2763238997 @default.
• W2896640994 cites W2767034994 @default.
• W2896640994 cites W2782007611 @default.
• W2896640994 cites W2783043796 @default.
• W2896640994 cites W2788431960 @default.
• W2896640994 cites W2791483720 @default.
• W2896640994 cites W2796207838 @default.
• W2896640994 cites W2796582438 @default.
• W2896640994 cites W2797675588 @default.
• W2896640994 cites W2797744035 @default.
• W2896640994 cites W2797855256 @default.
• W2896640994 cites W3149846182 @default.
• W2896640994 doi "https://doi.org/10.1080/2162402x.2018.1526613" @default.
• W2896640994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279340" @default.
• W2896640994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30524909" @default.
• W2896640994 hasPublicationYear "2018" @default.
• W2896640994 type Work @default.
• W2896640994 sameAs 2896640994 @default.
• W2896640994 citedByCount "54" @default.
• W2896640994 countsByYear W28966409942019 @default.
• W2896640994 countsByYear W28966409942020 @default.
• W2896640994 countsByYear W28966409942021 @default.
• W2896640994 countsByYear W28966409942022 @default.
• W2896640994 countsByYear W28966409942023 @default.
• W2896640994 crossrefType "journal-article" @default.
• W2896640994 hasAuthorship W2896640994A5018231423 @default.
• W2896640994 hasAuthorship W2896640994A5019845586 @default.
• W2896640994 hasAuthorship W2896640994A5023340072 @default.
• W2896640994 hasAuthorship W2896640994A5026607584 @default.
• W2896640994 hasAuthorship W2896640994A5029462216 @default.
• W2896640994 hasAuthorship W2896640994A5033698551 @default.
• W2896640994 hasAuthorship W2896640994A5072724582 @default.
• W2896640994 hasAuthorship W2896640994A5079885079 @default.
• W2896640994 hasAuthorship W2896640994A5081978650 @default.
• W2896640994 hasAuthorship W2896640994A5089035898 @default.
• W2896640994 hasBestOaLocation W28966409941 @default.
• W2896640994 hasConcept C121608353 @default.
• W2896640994 hasConcept C502942594 @default.
• W2896640994 hasConcept C54355233 @default.
• W2896640994 hasConcept C60644358 @default.
• W2896640994 hasConcept C70721500 @default.
• W2896640994 hasConcept C71924100 @default.
• W2896640994 hasConcept C86803240 @default.
• W2896640994 hasConceptScore W2896640994C121608353 @default.
• W2896640994 hasConceptScore W2896640994C502942594 @default.
• W2896640994 hasConceptScore W2896640994C54355233 @default.
• W2896640994 hasConceptScore W2896640994C60644358 @default.
• W2896640994 hasConceptScore W2896640994C70721500 @default.

• next