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• W2896654306 abstract "White matter hyperintensities (WMH) are cerebrovascular lesions that have been associated to an increased risk of developing Alzheimer's Disease (AD). This study aims to detect WMH topological patterns associated to AD risk factors in order to reveal common cerebrovascular mechanisms. 561 middle-aged cognitively healthy subjects were recruited as part of the ALFA cohort [1]. Age, hypertension, sex, hypercholesterolemia, diabetes, education, body mass index, depression, anxiety, physical exercise, family history of AD, and APOE were measured as risk factors. WMH were automatically segmented using the algorithm from Sudre et al [1] from T1 and FLAIR MRI scans. Regional WMH volumes were calculated for each brain lobe and four equidistant layers of distance to the ventricles [3]. Non-parametric analyses were performed to detect associations (p<0.05) with each individual risk factor (Model 1), after correcting for age (Model 2), and for age and hypertension (Model 3). Analyses comparing APOE genotypes were made using subjects matched by age and hypertension. Age and hypertension showed the most significant effect and largest spatial spread, mainly in frontal and parietal areas (Figure 1). Modifiable factors such as education, hypercholesterolemia and physical exercise were associated to a frontal pattern. Sex, anxiety and depression were associated to a juxtacortical pattern. Maternal family history and APOE-ε4 homozygosity were related to higher WMH load in deep white matter in occipital and parietal areas, respectively (Figure 2). Regional patterns of correlation with WMH. Model 1 shows raw correlations, whereas Model 2 and Model 3 show correlations correcting for age, and for age and hypertension, respectively. Colour coding represents significant association (p<0.05) with higher WMH. Grey regions depict no significant correlation. R: Right, L: Left, F: Frontal lobe, T: Temporal lobe, P: Parietal lobe, O: Occipital lobe and BG: Basal ganglia. Regional patterns of APOE correlation with WMH with matched subjects by age and hypertension. Colour coding represents significant association (p<0.05) with higher WMH. Grey regions depict no significant differences between groups. R: Right, L: Left, F: Frontal lobe, T: Temporal lobe, P: Parietal lobe, O: Occipital lobe and BG: Basal ganglia, ng: number of subjects in each group. Our results show that some of the studied risk factors share common patterns of WMH spatial localisation, thus suggesting common underlying effects. According to previous reports, the increased parietal WMH we observed in APOE-ε4 homozygotes might be a key mechanism contributing to their higher risk of developing dementia [4]. Our findings contribute to the understanding of cerebrovascular mechanisms that modify the risk of developing AD in cognitively healthy individuals. References: [1] Molinuevo JL, Alz & Dem. TRCI (2016) [2] Sudre CH, IEEE Trans Med Imaging (2015) [3] Sudre CH, J Neuroradiol (2017) [4] Brickman A, Alz. & Dem. (2014)." @default.
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• W2896654306 date "2018-07-01" @default.
• W2896654306 modified "2023-10-06" @default.
• W2896654306 title "O2‐13‐03: REGIONAL DISTRIBUTION OF WHITE MATTER HYPERINTENSITIES RELATED TO ALZHEIMER'S DISEASE RISK FACTORS IN THE ALFA COHORT" @default.
• W2896654306 doi "https://doi.org/10.1016/j.jalz.2018.06.2714" @default.
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