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• W2896655969 endingPage "939" @default.
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• W2896655969 abstract "Introduction: MicroRNAs (miRNA) are a class of small non-coding RNA that play a major role in various cellular processes by negatively regulating gene expression. In the past decade, miRNA dysregulation has been reported to be closely linked to inflammatory diseases. The immune response modulates cancer initiation and progression; miRNAs including let-7 family members have been shown to act as key regulators of the immune responses in various diseases and cancers. Notably, the let-7 miRNA has been reported to be closely associated with immunity, specifically with Toll-like receptors that mediate cytokine expression during pathogen infection and with the regulation of various other immune effectors.Areas covered: In this review, the authors describe the discovery of let-7 as the starting point of the RNA revolution and highlight let-7 as an efficient tool for cancer and immune therapy.Expert opinion: let-7 miRNA has emerged as a key player in cancer therapy and immune responses and it has potential role as a new immunotherapeutic target. However, while there are challenges regarding miRNA delivery, the exciting emergence of personalized medicine for cancer and immunotherapy could be beneficial for the development of let-7 therapeutics." @default.
• W2896655969 created "2018-10-26" @default.
• W2896655969 creator A5013989133 @default.
• W2896655969 creator A5042296387 @default.
• W2896655969 date "2018-10-17" @default.
• W2896655969 modified "2023-10-01" @default.
• W2896655969 title "<i>Let-7</i> microRNA as a potential therapeutic target with implications for immunotherapy" @default.
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• W2896655969 doi "https://doi.org/10.1080/14728222.2018.1535594" @default.
• W2896655969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337723" @default.
• W2896655969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30328720" @default.
• W2896655969 hasPublicationYear "2018" @default.
• W2896655969 type Work @default.
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