FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896656458> ?p ?o ?g. }

• W2896656458 abstract "Abstract The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition suppressed tumor cell proliferation and invasion. The p90 ribosomal S6 kinase (RSK), an important ERK effector, activates YB-1 to drive melanoma growth. We found that fisetin treatment of monolayer/3-D melanoma cultures resulted in YB-1 dephosphorylation and reduced transcript levels. In parallel, fisetin suppressed mesenchymal markers and matrix-metalloproteinases in melanoma cells. Data from cell-free/cell-based systems indicated that fisetin inhibited RSK activity through binding to the kinase. Affinity studies for RSK isoforms evaluated stronger interaction for RSK2 than RSK1. Competition assays performed to monitor binding responses revealed that YB-1 and RSK2 do not compete, rather binding of fisetin to RSK2 promotes its binding to YB-1. Fisetin suppressed YB-1/RSK signaling independent of its effect on ERK, and reduced MDR1 levels. Comparable efficacy of fisetin and vemurafenib for inhibiting melanoma growth was noted albeit through divergent modulation of ERK. Our studies provide insight into additional modes of regulation through which fisetin interferes with melanoma growth underscoring its potential therapeutic efficacy in disease progression." @default.
• W2896656458 created "2018-10-26" @default.
• W2896656458 creator A5011474499 @default.
• W2896656458 creator A5026964548 @default.
• W2896656458 creator A5030030576 @default.
• W2896656458 creator A5040046127 @default.
• W2896656458 creator A5057170434 @default.
• W2896656458 creator A5060174001 @default.
• W2896656458 creator A5077795264 @default.
• W2896656458 creator A5082425428 @default.
• W2896656458 date "2018-10-24" @default.
• W2896656458 modified "2023-10-13" @default.
• W2896656458 title "Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models" @default.
• W2896656458 cites W1558187819 @default.
• W2896656458 cites W1827837756 @default.
• W2896656458 cites W1938563613 @default.
• W2896656458 cites W1974794868 @default.
• W2896656458 cites W1977507384 @default.
• W2896656458 cites W1986919010 @default.
• W2896656458 cites W1988723429 @default.
• W2896656458 cites W1999971302 @default.
• W2896656458 cites W2005639991 @default.
• W2896656458 cites W2040285331 @default.
• W2896656458 cites W2042625441 @default.
• W2896656458 cites W2054557456 @default.
• W2896656458 cites W2059889717 @default.
• W2896656458 cites W2064795762 @default.
• W2896656458 cites W2064854415 @default.
• W2896656458 cites W2068420134 @default.
• W2896656458 cites W2086819792 @default.
• W2896656458 cites W2090740489 @default.
• W2896656458 cites W2097578848 @default.
• W2896656458 cites W2103701382 @default.
• W2896656458 cites W2110054974 @default.
• W2896656458 cites W2118722680 @default.
• W2896656458 cites W2129335039 @default.
• W2896656458 cites W2134592811 @default.
• W2896656458 cites W2140117696 @default.
• W2896656458 cites W2140850919 @default.
• W2896656458 cites W2149775431 @default.
• W2896656458 cites W2153940383 @default.
• W2896656458 cites W2154053380 @default.
• W2896656458 cites W2156498897 @default.
• W2896656458 cites W2160219683 @default.
• W2896656458 cites W2160493566 @default.
• W2896656458 cites W2167100625 @default.
• W2896656458 cites W2167678837 @default.
• W2896656458 cites W2197752186 @default.
• W2896656458 cites W2300290254 @default.
• W2896656458 cites W2343596022 @default.
• W2896656458 cites W2344712954 @default.
• W2896656458 cites W2353530036 @default.
• W2896656458 cites W2405976160 @default.
• W2896656458 cites W2529918369 @default.
• W2896656458 cites W2544147855 @default.
• W2896656458 cites W2564822919 @default.
• W2896656458 cites W2623191882 @default.
• W2896656458 cites W4234665826 @default.
• W2896656458 doi "https://doi.org/10.1038/s41598-018-33879-w" @default.
• W2896656458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200766" @default.
• W2896656458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30356079" @default.
• W2896656458 hasPublicationYear "2018" @default.
• W2896656458 type Work @default.
• W2896656458 sameAs 2896656458 @default.
• W2896656458 citedByCount "34" @default.
• W2896656458 countsByYear W28966564582019 @default.
• W2896656458 countsByYear W28966564582020 @default.
• W2896656458 countsByYear W28966564582021 @default.
• W2896656458 countsByYear W28966564582022 @default.
• W2896656458 countsByYear W28966564582023 @default.
• W2896656458 crossrefType "journal-article" @default.
• W2896656458 hasAuthorship W2896656458A5011474499 @default.
• W2896656458 hasAuthorship W2896656458A5026964548 @default.
• W2896656458 hasAuthorship W2896656458A5030030576 @default.
• W2896656458 hasAuthorship W2896656458A5040046127 @default.
• W2896656458 hasAuthorship W2896656458A5057170434 @default.
• W2896656458 hasAuthorship W2896656458A5060174001 @default.
• W2896656458 hasAuthorship W2896656458A5077795264 @default.
• W2896656458 hasAuthorship W2896656458A5082425428 @default.
• W2896656458 hasBestOaLocation W28966564581 @default.
• W2896656458 hasConcept C11960822 @default.
• W2896656458 hasConcept C178666793 @default.
• W2896656458 hasConcept C181912034 @default.
• W2896656458 hasConcept C184235292 @default.
• W2896656458 hasConcept C185592680 @default.
• W2896656458 hasConcept C207001950 @default.
• W2896656458 hasConcept C2776131300 @default.
• W2896656458 hasConcept C2777376040 @default.
• W2896656458 hasConcept C2777658100 @default.
• W2896656458 hasConcept C2778004101 @default.
• W2896656458 hasConcept C2779054382 @default.
• W2896656458 hasConcept C2994587330 @default.
• W2896656458 hasConcept C502942594 @default.
• W2896656458 hasConcept C54355233 @default.
• W2896656458 hasConcept C55493867 @default.
• W2896656458 hasConcept C57074206 @default.
• W2896656458 hasConcept C62112901 @default.
• W2896656458 hasConcept C86803240 @default.
• W2896656458 hasConcept C95444343 @default.
• W2896656458 hasConcept C98274493 @default.

• next