Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896657170> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2896657170 endingPage "S978" @default.
- W2896657170 startingPage "S977" @default.
- W2896657170 abstract "In this case series we present ten patients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) treated with lorlatinib. Lorlatinib is highly potent and selective third generation ALK and ROS1 tyrosine kinase inhibitor (TKI) with known activity against most resistance mutations. In a phase 1 study, lorlatinib showed intracranial and systemic activity in ROS1-positive and ALK-positive patients with advanced NSCLC. Thus far, we treated 6 ALK- and 4 ROS1-positive stage IV NSCLC patients with lorlatinib in a compassionate use program. Best response was complete remission in two of our patients. One ROS1-positive patient with CNS metastases has now ongoing complete response for 27 months; the other patient with a ALK-positive NSCLC with CNS metastasis has now been treated with lorlatinib for 16 months. Three patients showed a partial response with an ongoing progression free survival of respectively 3, 5 and 8 months. Two of our patients (one ALK-positive and one ROS1-positive NSCLC) showed progressive disease as best response. In three patients response data is not (yet) available. There were no significant side effect apart from hypercholesterolemia, which occurred in four of our patients. Lorlatinib shows promise in the treatment of ROS1-positive and ALK-positive patients with advanced NSCLC." @default.
- W2896657170 created "2018-10-26" @default.
- W2896657170 creator A5005308154 @default.
- W2896657170 creator A5038251229 @default.
- W2896657170 creator A5051331698 @default.
- W2896657170 creator A5080214476 @default.
- W2896657170 date "2018-10-01" @default.
- W2896657170 modified "2023-10-14" @default.
- W2896657170 title "P3.13-04 Lorlatinib in Anaplastic Lymphoma Kinase and Proto-Oncogene Tyrosine-Protein Kinase ROS-Positive Non-Small Cell Lung Cancer" @default.
- W2896657170 doi "https://doi.org/10.1016/j.jtho.2018.08.1844" @default.
- W2896657170 hasPublicationYear "2018" @default.
- W2896657170 type Work @default.
- W2896657170 sameAs 2896657170 @default.
- W2896657170 citedByCount "0" @default.
- W2896657170 crossrefType "journal-article" @default.
- W2896657170 hasAuthorship W2896657170A5005308154 @default.
- W2896657170 hasAuthorship W2896657170A5038251229 @default.
- W2896657170 hasAuthorship W2896657170A5051331698 @default.
- W2896657170 hasAuthorship W2896657170A5080214476 @default.
- W2896657170 hasBestOaLocation W28966571701 @default.
- W2896657170 hasConcept C117643217 @default.
- W2896657170 hasConcept C121608353 @default.
- W2896657170 hasConcept C126322002 @default.
- W2896657170 hasConcept C143998085 @default.
- W2896657170 hasConcept C170493617 @default.
- W2896657170 hasConcept C2775999482 @default.
- W2896657170 hasConcept C2776232967 @default.
- W2896657170 hasConcept C2776256026 @default.
- W2896657170 hasConcept C2778347629 @default.
- W2896657170 hasConcept C2778820342 @default.
- W2896657170 hasConcept C2779422266 @default.
- W2896657170 hasConcept C2781018059 @default.
- W2896657170 hasConcept C2781182431 @default.
- W2896657170 hasConcept C2909867262 @default.
- W2896657170 hasConcept C29537977 @default.
- W2896657170 hasConcept C42362537 @default.
- W2896657170 hasConcept C502942594 @default.
- W2896657170 hasConcept C71924100 @default.
- W2896657170 hasConceptScore W2896657170C117643217 @default.
- W2896657170 hasConceptScore W2896657170C121608353 @default.
- W2896657170 hasConceptScore W2896657170C126322002 @default.
- W2896657170 hasConceptScore W2896657170C143998085 @default.
- W2896657170 hasConceptScore W2896657170C170493617 @default.
- W2896657170 hasConceptScore W2896657170C2775999482 @default.
- W2896657170 hasConceptScore W2896657170C2776232967 @default.
- W2896657170 hasConceptScore W2896657170C2776256026 @default.
- W2896657170 hasConceptScore W2896657170C2778347629 @default.
- W2896657170 hasConceptScore W2896657170C2778820342 @default.
- W2896657170 hasConceptScore W2896657170C2779422266 @default.
- W2896657170 hasConceptScore W2896657170C2781018059 @default.
- W2896657170 hasConceptScore W2896657170C2781182431 @default.
- W2896657170 hasConceptScore W2896657170C2909867262 @default.
- W2896657170 hasConceptScore W2896657170C29537977 @default.
- W2896657170 hasConceptScore W2896657170C42362537 @default.
- W2896657170 hasConceptScore W2896657170C502942594 @default.
- W2896657170 hasConceptScore W2896657170C71924100 @default.
- W2896657170 hasIssue "10" @default.
- W2896657170 hasLocation W28966571701 @default.
- W2896657170 hasOpenAccess W2896657170 @default.
- W2896657170 hasPrimaryLocation W28966571701 @default.
- W2896657170 hasRelatedWork W1987801860 @default.
- W2896657170 hasRelatedWork W2006164250 @default.
- W2896657170 hasRelatedWork W2024963052 @default.
- W2896657170 hasRelatedWork W2045309793 @default.
- W2896657170 hasRelatedWork W2156486640 @default.
- W2896657170 hasRelatedWork W2304533799 @default.
- W2896657170 hasRelatedWork W2342063662 @default.
- W2896657170 hasRelatedWork W3137415510 @default.
- W2896657170 hasRelatedWork W3199005851 @default.
- W2896657170 hasRelatedWork W3206194752 @default.
- W2896657170 hasVolume "13" @default.
- W2896657170 isParatext "false" @default.
- W2896657170 isRetracted "false" @default.
- W2896657170 magId "2896657170" @default.
- W2896657170 workType "article" @default.