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- W2896659281 abstract "Large doses of elastases instilled into the lungs of animals produce emphysema. Since the human disease is unlikely to be the result of a single overwhelming elastolytic insult, the results of such models may not be entirely applicable to man. In the animal model, a single injection of elastase produces rapid destruction of elastin, an acute inflammatory reaction which subsides over 3-5 days, and progressively severe emphysema. Comparison of the acute effects of comparable doses of two different elastases indicates that granulocyte elastase produces more widespread tissue injury, but pancreatic elastase greater destruction of elastin and more severe emphysema. The inflammatory response to the injected enzyme does not appear to contribute to the tissue destruction caused by elastase in this model. When cyclophosphamide or antigranulocyte serum are used to ameliorate the iflammatory response, no decrease in either the destruction of elastin or the severity of nphysema is seen. The destroyed elastin is gradually replaced by new fibers which have a normal ultrastructure, amino acid composition, and crosslinks but disorganized architecture. Interference with the resynthesis of the elastic fibers by inhibition of crosslinking with β-aminoproprionitrile or penicillamine results in marked worsening of the emphysema and the formation of bullae. These results emphasize the primacy of the destruction of elastin ver general tissue injury in the genesis of emphysema and suggest that the balance between destruction and resynthesis of elastin is a major determinant of the severity of the disease." @default.
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- W2896659281 date "1981-01-01" @default.
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- W2896659281 title "THE TISSUE RESPONSE TO EXOGENOUS ELASTASE" @default.
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- W2896659281 doi "https://doi.org/10.1016/b978-0-08-027379-2.50014-4" @default.
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