FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896659890> ?p ?o ?g. }

• W2896659890 endingPage "1324" @default.
• W2896659890 startingPage "1285" @default.
• W2896659890 abstract "Significance: Decrypting the cellular response to oxidative stress relies on a comprehensive understanding of the redox signaling pathways stimulated under oxidizing conditions. Redox signaling events can be divided into upstream sensing of oxidants, midstream redox signaling of protein function, and downstream transcriptional redox regulation. Recent Advances: A more and more accepted theory of hydrogen peroxide (H2O2) signaling is that of a thiol peroxidase redox relay, whereby protein thiols with low reactivity toward H2O2 are instead oxidized through an oxidative relay with thiol peroxidases. Critical Issues: These ultrareactive thiol peroxidases are the upstream redox sensors, which form the first cellular port of call for H2O2. Not all redox-regulated interactions between thiol peroxidases and cellular proteins involve a transfer of oxidative equivalents, and the nature of redox signaling is further complicated through promiscuous functions of redox-regulated “moonlighting” proteins, of which the precise cellular role under oxidative stress can frequently be obscured by “polygamous” interactions. An ultimate goal of redox signaling is to initiate a rapid response, and in contrast to prokaryotic oxidant-responsive transcription factors, mammalian systems have developed redox signaling pathways, which intersect both with kinase-dependent activation of transcription factors, as well as direct oxidative regulation of transcription factors through peroxiredoxin (Prx) redox relays. Future Directions: We highlight that both transcriptional regulation and cell fate can be modulated either through oxidative regulation of kinase pathways, or through distinct redox-dependent associations involving either Prxs or redox-responsive moonlighting proteins with functional promiscuity. These protein associations form systems of crossregulatory networks with multiple nodes of potential oxidative regulation for H2O2-mediated signaling." @default.
• W2896659890 created "2018-10-26" @default.
• W2896659890 creator A5001126336 @default.
• W2896659890 creator A5015540363 @default.
• W2896659890 creator A5017123045 @default.
• W2896659890 creator A5024057663 @default.
• W2896659890 creator A5029193641 @default.
• W2896659890 creator A5033040268 @default.
• W2896659890 creator A5037655478 @default.
• W2896659890 creator A5037662414 @default.
• W2896659890 creator A5040530477 @default.
• W2896659890 creator A5076479367 @default.
• W2896659890 creator A5091136034 @default.
• W2896659890 date "2019-04-01" @default.
• W2896659890 modified "2023-10-14" @default.
• W2896659890 title "Protein Promiscuity in H₂O₂Signaling" @default.
• W2896659890 cites W1158097820 @default.
• W2896659890 cites W130146406 @default.
• W2896659890 cites W1486336224 @default.
• W2896659890 cites W1487196831 @default.
• W2896659890 cites W1492951734 @default.
• W2896659890 cites W1514298620 @default.
• W2896659890 cites W1526675429 @default.
• W2896659890 cites W1531660741 @default.
• W2896659890 cites W1571946308 @default.
• W2896659890 cites W1669539776 @default.
• W2896659890 cites W1679004065 @default.
• W2896659890 cites W17607008 @default.
• W2896659890 cites W181556572 @default.
• W2896659890 cites W1854727002 @default.
• W2896659890 cites W1858880507 @default.
• W2896659890 cites W1904882453 @default.
• W2896659890 cites W1907632959 @default.
• W2896659890 cites W1921965616 @default.
• W2896659890 cites W1923409750 @default.
• W2896659890 cites W1943329167 @default.
• W2896659890 cites W1963446535 @default.
• W2896659890 cites W1963952617 @default.
• W2896659890 cites W1964011057 @default.
• W2896659890 cites W1964296070 @default.
• W2896659890 cites W1965029154 @default.
• W2896659890 cites W1965826248 @default.
• W2896659890 cites W1967591316 @default.
• W2896659890 cites W1967603366 @default.
• W2896659890 cites W1967866736 @default.
• W2896659890 cites W1968240129 @default.
• W2896659890 cites W1969268163 @default.
• W2896659890 cites W1969275607 @default.
• W2896659890 cites W1969360388 @default.
• W2896659890 cites W1971090593 @default.
• W2896659890 cites W1971895154 @default.
• W2896659890 cites W1972134221 @default.
• W2896659890 cites W1973474734 @default.
• W2896659890 cites W1973646126 @default.
• W2896659890 cites W1974747062 @default.
• W2896659890 cites W1975084717 @default.
• W2896659890 cites W1975695039 @default.
• W2896659890 cites W1975734731 @default.
• W2896659890 cites W1976087136 @default.
• W2896659890 cites W1976393002 @default.
• W2896659890 cites W1977186059 @default.
• W2896659890 cites W1977990240 @default.
• W2896659890 cites W1978961333 @default.
• W2896659890 cites W1981120411 @default.
• W2896659890 cites W1981786531 @default.
• W2896659890 cites W1982205139 @default.
• W2896659890 cites W1982972167 @default.
• W2896659890 cites W1983316037 @default.
• W2896659890 cites W1983688655 @default.
• W2896659890 cites W1984387620 @default.
• W2896659890 cites W1984895597 @default.
• W2896659890 cites W1984932018 @default.
• W2896659890 cites W1985730402 @default.
• W2896659890 cites W1985911054 @default.
• W2896659890 cites W1985962374 @default.
• W2896659890 cites W1986320836 @default.
• W2896659890 cites W1986717393 @default.
• W2896659890 cites W1989400319 @default.
• W2896659890 cites W1989861214 @default.
• W2896659890 cites W1989914560 @default.
• W2896659890 cites W1990847293 @default.
• W2896659890 cites W1991105829 @default.
• W2896659890 cites W1991436274 @default.
• W2896659890 cites W1991597523 @default.
• W2896659890 cites W1991631628 @default.
• W2896659890 cites W1991845993 @default.
• W2896659890 cites W1991952977 @default.
• W2896659890 cites W1992024372 @default.
• W2896659890 cites W1992681584 @default.
• W2896659890 cites W1992740290 @default.
• W2896659890 cites W1993358648 @default.
• W2896659890 cites W1993394860 @default.
• W2896659890 cites W1994043227 @default.
• W2896659890 cites W1994429692 @default.
• W2896659890 cites W1994500027 @default.
• W2896659890 cites W1995252461 @default.
• W2896659890 cites W1995577457 @default.
• W2896659890 cites W1997161797 @default.

• next