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• W2896660300 abstract "Subcategorization of mild cognitive impairment (MCI) into the clinical phenotypes of amnestic and non-amnestic MCI (aMCI and naMCI) has shown that aMCI is associated with yet an even higher risk of conversion to AD. aMCI, naMCI likely have distinct pathophysiologies and disease trajectories. Therefore, accurate characterisation and subtyping of MCI is particularly important both from aetiological as well as prognostic perspectives. By utilising a stringent approach to distinguishing aMCI vs. naMCI, we aim to a) identify whether this approach is supported by whole and subfield hippocampal volumetric differences; b) to determine subfield biomarkers that differentiate MCI subtypes; c) to identify which subfields significantly predict memory and learning performance in each MCI subtype. Standard 3D structural MRI was acquired in 129 patients recruited from the Healthy Brain Ageing Clinic (HBA) diagnosed with aMCI (n = 34), naMCI (n = 75) or subjective memory complaints (SMC) (n = 20). All participants underwent neurological and neuropsychological assessment1. Memory, auditory learning and cognitive performance was assessed using the Logical Memory I &II score, Rey Auditory Verbal Learning Test and MMSE. aMCI was diagnosed based on deficits in delayed recall (not new learning). 3D T1-weighted datasets were automatically processed with the freely available FreeSurfer (v6.0) to extract reliable whole hippocampal and subfield volumes2. One-Way ANCOVA were used to compare volumetric measures between clinical groups. Multiple linear regressions were used to investigate the association with memory performance and subfield volume in MCI groups. Whole and subfield hippocampal volumes were significantly reduced in aMCI, predominantly in the Subiculum, CA1 CA3 and Dentate gyrus (Fig 1). These 4 subfield volumes were also significant predictors of memory performance specifically within this group. Hippocampal volumetric analysis. Marginal mean (SD) plots of left (A) and right (C) whole hippocampal, and the memory associated subfields Subiculum, CA1, CA3 and Dentate gyrus volumes from SMC, aMCI and naMCI patient groups. Iso-surface renderings of an example whole hippocampal segmentation superimposed on coronal and axial planes of a structural 3D T1-weighted dataset (B) are displayed for reference purposes. Hippocampal subfield analysis reveals significant and functionally relevant group differences, supporting the stringent characterization of aMCI according to delayed recall only, suggesting that our characterisation of the MCI subtypes is not merely theoretical but is supported by key neurophysiological differences. Here we identify hippocampal subfields as potential biomarkers to differentiate these three patient groups in the early stages of disease and isolate specific subfields that significantly predict cognitive and memory performance in both aMCI and naMCI." @default.
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• W2896660300 date "2018-07-01" @default.
• W2896660300 modified "2023-10-16" @default.
• W2896660300 title "P1‐389: DIFFERENTIATION BETWEEN MILD COGNITIVE IMPAIRMENT SUBGROUPS BY HIPPOCAMPAL SUBFIELDS" @default.
• W2896660300 doi "https://doi.org/10.1016/j.jalz.2018.06.397" @default.
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