FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896662218> ?p ?o ?g. }

• W2896662218 endingPage "14822" @default.
• W2896662218 startingPage "14807" @default.
• W2896662218 abstract "The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are described. They are composed of derivatives of the neutral, tridentate ligand triazacyclononane (R3TACN; R = Me, iPr) and 2-aminobenzenethiolate (abtx; X = H, CF3), a non-native substrate for thiol dioxygenases. The coordination number of these complexes depends on the identity of the TACN derivative, giving 6-coordinate (6-coord) complexes for FeII(Me3TACN)(abtx)(OTf) (1: X = H; 2: X = CF3) and 5-coordinate (5-coord) complexes for [FeII(iPr3TACN)(abtx)](OTf) (3: X = H; 4: X = CF3). Complexes 1-4 were examined by UV-vis, 1H/19F NMR, and Mössbauer spectroscopies, and density functional theory (DFT) calculations were employed to support the data. Mössbauer spectroscopy reveals that the 6-coord 1-2 and 5-coord 3- 4 exhibit distinct spectra, and these data are compared with that for cysteine-bound CDO, helping to clarify the coordination environment of the cys-bound FeII active site. Reaction of 1 or 2 with O2 at -95 °C leads to S-oxygenation of the abt ligand, and in the case of 2, a rare di(sulfinato)-bridged complex, [Fe2III(μ-O)((2-NH2) p-CF3C6H3SO2)2](OTf)2 ( 5), was obtained. Parallel enzymatic studies on the CDO variant C93G were carried out with the abt substrate and show that reaction with O2 leads to disulfide formation, as opposed to S-oxygenation. The combined model and enzyme studies show that the thiol dioxygenases can operate via a 6-coord FeII center, in contrast to the accepted mechanism for nonheme iron dioxygenases, and that proper substrate chelation to Fe appears to be critical for S-oxygenation." @default.
• W2896662218 created "2018-10-26" @default.
• W2896662218 creator A5001206269 @default.
• W2896662218 creator A5005123295 @default.
• W2896662218 creator A5011116302 @default.
• W2896662218 creator A5030193476 @default.
• W2896662218 creator A5035006133 @default.
• W2896662218 creator A5063906736 @default.
• W2896662218 creator A5078128013 @default.
• W2896662218 date "2018-10-22" @default.
• W2896662218 modified "2023-10-16" @default.
• W2896662218 title "Structures, Spectroscopic Properties, and Dioxygen Reactivity of 5- and 6-Coordinate Nonheme Iron(II) Complexes: A Combined Enzyme/Model Study of Thiol Dioxygenases" @default.
• W2896662218 cites W1187783311 @default.
• W2896662218 cites W170526692 @default.
• W2896662218 cites W1965880837 @default.
• W2896662218 cites W1967700647 @default.
• W2896662218 cites W1969471242 @default.
• W2896662218 cites W1971194745 @default.
• W2896662218 cites W1971275758 @default.
• W2896662218 cites W1971464008 @default.
• W2896662218 cites W1971548560 @default.
• W2896662218 cites W1972094203 @default.
• W2896662218 cites W1975708211 @default.
• W2896662218 cites W1979537683 @default.
• W2896662218 cites W1979965731 @default.
• W2896662218 cites W1982018391 @default.
• W2896662218 cites W1982025807 @default.
• W2896662218 cites W1983845336 @default.
• W2896662218 cites W1984113094 @default.
• W2896662218 cites W1988091937 @default.
• W2896662218 cites W1991456391 @default.
• W2896662218 cites W1992833218 @default.
• W2896662218 cites W1993431898 @default.
• W2896662218 cites W1996079859 @default.
• W2896662218 cites W1996273492 @default.
• W2896662218 cites W1998613997 @default.
• W2896662218 cites W2000997978 @default.
• W2896662218 cites W2004362095 @default.
• W2896662218 cites W2008423326 @default.
• W2896662218 cites W2008595025 @default.
• W2896662218 cites W2011215428 @default.
• W2896662218 cites W2011278625 @default.
• W2896662218 cites W2020002104 @default.
• W2896662218 cites W2023271753 @default.
• W2896662218 cites W2024263909 @default.
• W2896662218 cites W2024948656 @default.
• W2896662218 cites W2025885285 @default.
• W2896662218 cites W2027581929 @default.
• W2896662218 cites W2028704771 @default.
• W2896662218 cites W2030687437 @default.
• W2896662218 cites W2032719166 @default.
• W2896662218 cites W2033639648 @default.
• W2896662218 cites W2034890453 @default.
• W2896662218 cites W2036499751 @default.
• W2896662218 cites W2037884664 @default.
• W2896662218 cites W2039293281 @default.
• W2896662218 cites W2042705716 @default.
• W2896662218 cites W2045236580 @default.
• W2896662218 cites W2045294290 @default.
• W2896662218 cites W2045436597 @default.
• W2896662218 cites W2047192776 @default.
• W2896662218 cites W2047241505 @default.
• W2896662218 cites W2051576393 @default.
• W2896662218 cites W2055563809 @default.
• W2896662218 cites W2059710590 @default.
• W2896662218 cites W2060711800 @default.
• W2896662218 cites W2062852634 @default.
• W2896662218 cites W2065653048 @default.
• W2896662218 cites W2065681892 @default.
• W2896662218 cites W2066611120 @default.
• W2896662218 cites W2066870295 @default.
• W2896662218 cites W2067718414 @default.
• W2896662218 cites W2070432790 @default.
• W2896662218 cites W2071617601 @default.
• W2896662218 cites W2074371194 @default.
• W2896662218 cites W2076799189 @default.
• W2896662218 cites W2077805528 @default.
• W2896662218 cites W2078146328 @default.
• W2896662218 cites W2079147951 @default.
• W2896662218 cites W2083321854 @default.
• W2896662218 cites W2083719587 @default.
• W2896662218 cites W2084229335 @default.
• W2896662218 cites W2084778777 @default.
• W2896662218 cites W2090245920 @default.
• W2896662218 cites W2091913250 @default.
• W2896662218 cites W2092196805 @default.
• W2896662218 cites W2099037802 @default.
• W2896662218 cites W2103400998 @default.
• W2896662218 cites W2105249240 @default.
• W2896662218 cites W2109816371 @default.
• W2896662218 cites W2119550359 @default.
• W2896662218 cites W2133133258 @default.
• W2896662218 cites W2134382177 @default.
• W2896662218 cites W2143981217 @default.
• W2896662218 cites W2148284063 @default.
• W2896662218 cites W2178527074 @default.
• W2896662218 cites W2315795462 @default.
• W2896662218 cites W2319902168 @default.

• next