Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896663140> ?p ?o ?g. }
- W2896663140 abstract "The retinal disease gene peripherin 2 (PRPH2) is essential for the formation of photoreceptor outer segments (OSs), where it functions in oligomers with and without its homologue ROM1. However, the precise role of these proteins in OS morphogenesis is not understood. By utilizing a knock-in mouse expressing a chimeric protein comprised of the body of Rom1 and the C-terminus of Prph2 (termed RRCT), we find that the Prph2 C-terminus is necessary and sufficient for the initiation of OSs, while OS maturation requires the body of Prph2 and associated large oligomers. Importantly, dominant-negative physiological and biochemical defects in RRCT heterozygous rods are rescued by removing Rom1, suggesting Rom1 is a regulator for OS formation. Our experiments evaluating Prph2 trafficking show that Rom1 is a key determinant of whether Prph2 complexes utilize conventional versus unconventional (Golgi bypass) secretory pathways to reach the OS. These findings significantly advance our understanding of the molecular underpinnings of OS morphogenesis and particularly the role of Rom1." @default.
- W2896663140 created "2018-10-26" @default.
- W2896663140 creator A5025204714 @default.
- W2896663140 creator A5031536121 @default.
- W2896663140 creator A5047613287 @default.
- W2896663140 creator A5058931529 @default.
- W2896663140 creator A5066163897 @default.
- W2896663140 creator A5080127995 @default.
- W2896663140 date "2018-10-10" @default.
- W2896663140 modified "2023-09-23" @default.
- W2896663140 title "Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization" @default.
- W2896663140 cites W1259991921 @default.
- W2896663140 cites W1584230006 @default.
- W2896663140 cites W1588405163 @default.
- W2896663140 cites W1969461625 @default.
- W2896663140 cites W1969529794 @default.
- W2896663140 cites W1971035936 @default.
- W2896663140 cites W1973418075 @default.
- W2896663140 cites W1977184155 @default.
- W2896663140 cites W1982166146 @default.
- W2896663140 cites W1989683816 @default.
- W2896663140 cites W1993779386 @default.
- W2896663140 cites W1993805514 @default.
- W2896663140 cites W1995776276 @default.
- W2896663140 cites W1996022909 @default.
- W2896663140 cites W1997062000 @default.
- W2896663140 cites W2000205353 @default.
- W2896663140 cites W2000232627 @default.
- W2896663140 cites W2000429226 @default.
- W2896663140 cites W2004014468 @default.
- W2896663140 cites W2007127198 @default.
- W2896663140 cites W2007915197 @default.
- W2896663140 cites W2014819717 @default.
- W2896663140 cites W2029441872 @default.
- W2896663140 cites W2032338309 @default.
- W2896663140 cites W2033393155 @default.
- W2896663140 cites W2033852655 @default.
- W2896663140 cites W2034804512 @default.
- W2896663140 cites W2036584633 @default.
- W2896663140 cites W2046263355 @default.
- W2896663140 cites W2055989493 @default.
- W2896663140 cites W2059671927 @default.
- W2896663140 cites W2063636670 @default.
- W2896663140 cites W2068396294 @default.
- W2896663140 cites W2074202884 @default.
- W2896663140 cites W2085374398 @default.
- W2896663140 cites W2086470900 @default.
- W2896663140 cites W2093669238 @default.
- W2896663140 cites W2094117679 @default.
- W2896663140 cites W2108788043 @default.
- W2896663140 cites W2110829301 @default.
- W2896663140 cites W2110864371 @default.
- W2896663140 cites W2115715721 @default.
- W2896663140 cites W2123814643 @default.
- W2896663140 cites W2124018623 @default.
- W2896663140 cites W2130322765 @default.
- W2896663140 cites W2132146273 @default.
- W2896663140 cites W2138967544 @default.
- W2896663140 cites W2168345599 @default.
- W2896663140 cites W2337718683 @default.
- W2896663140 cites W2472608369 @default.
- W2896663140 cites W2569276661 @default.
- W2896663140 cites W2599265893 @default.
- W2896663140 cites W2604399914 @default.
- W2896663140 cites W2809790884 @default.
- W2896663140 cites W37803518 @default.
- W2896663140 doi "https://doi.org/10.1093/hmg/ddy359" @default.
- W2896663140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337695" @default.
- W2896663140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307502" @default.
- W2896663140 hasPublicationYear "2018" @default.
- W2896663140 type Work @default.
- W2896663140 sameAs 2896663140 @default.
- W2896663140 citedByCount "20" @default.
- W2896663140 countsByYear W28966631402019 @default.
- W2896663140 countsByYear W28966631402020 @default.
- W2896663140 countsByYear W28966631402021 @default.
- W2896663140 countsByYear W28966631402022 @default.
- W2896663140 countsByYear W28966631402023 @default.
- W2896663140 crossrefType "journal-article" @default.
- W2896663140 hasAuthorship W2896663140A5025204714 @default.
- W2896663140 hasAuthorship W2896663140A5031536121 @default.
- W2896663140 hasAuthorship W2896663140A5047613287 @default.
- W2896663140 hasAuthorship W2896663140A5058931529 @default.
- W2896663140 hasAuthorship W2896663140A5066163897 @default.
- W2896663140 hasAuthorship W2896663140A5080127995 @default.
- W2896663140 hasBestOaLocation W28966631402 @default.
- W2896663140 hasConcept C104317684 @default.
- W2896663140 hasConcept C119062480 @default.
- W2896663140 hasConcept C127716648 @default.
- W2896663140 hasConcept C158617107 @default.
- W2896663140 hasConcept C207177822 @default.
- W2896663140 hasConcept C40692019 @default.
- W2896663140 hasConcept C54355233 @default.
- W2896663140 hasConcept C6929976 @default.
- W2896663140 hasConcept C86803240 @default.
- W2896663140 hasConcept C95444343 @default.
- W2896663140 hasConceptScore W2896663140C104317684 @default.
- W2896663140 hasConceptScore W2896663140C119062480 @default.
- W2896663140 hasConceptScore W2896663140C127716648 @default.
- W2896663140 hasConceptScore W2896663140C158617107 @default.