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• W2896664811 abstract "A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K562 cells and breast cancer MCF-7 cells. Biological evaluation indicated that the most active compound I-5 produced high levels of NO and inhibited the proliferation of K562 (IC50 1.55 μmol·L−1) and MCF-7 (IC50 2.91 μmol·L−1) cells, which were more potent than the lead compound TAD and attenuated by an NO scavenger. In conclusion, I-5 is a novel hybrid with potent antitumor activity and may become a promising candidate for future intensive study." @default.
• W2896664811 created "2018-10-26" @default.
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• W2896664811 date "2018-10-01" @default.
• W2896664811 modified "2023-10-16" @default.
• W2896664811 title "Design, synthesis, and biological evaluation of novel nitric oxide releasing dehydroandrographolide derivatives" @default.
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• W2896664811 doi "https://doi.org/10.1016/s1875-5364(18)30118-3" @default.
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