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• W2896667103 endingPage "3140" @default.
• W2896667103 startingPage "3123" @default.
• W2896667103 abstract "The scenario of chemical reactions prompted by the infection by Mycobacterium tuberculosis is huge. The infection generates a localized inflammatory response, with the recruitment of neutrophils, monocytes, and T-lymphocytes. Consequences of this immune reaction can be the eradication or containment of the infection, but these events can be deleterious to the host inasmuch as lung tissue can be destroyed. Indeed, a hallmark of tuberculosis (TB) is the formation of lung cavities, which increase disease development and transmission, as they are sites of high mycobacterial burden. Pulmonary cavitation is associated with antibiotic failure and the emergence of antibiotic resistance. For cavities to form, M. tuberculosis induces the overexpression of host proteases, like matrix metalloproteinases and cathepsin, which are secreted from monocyte-derived cells, neutrophils, and stromal cells. These proteases destroy the lung parenchyma, in particular the collagen constituent of the extracellular matrix (ECM). Namely, in an attempt to destroy infected cells, the immune reactions prompted by mycobacterial infections induce the destruction of vital regions of the lung, in a process that can become fatal. Here, we review structure and function of the main molecular actors of ECM degradation due to M. tuberculosis infection and the proposed mechanisms of tissue destruction, mainly attacking fibrillar collagen. Importantly, enzymes responsible for collagen destruction are emerging as key targets for adjunctive therapies to limit immunopathology in TB." @default.
• W2896667103 created "2018-10-26" @default.
• W2896667103 creator A5037511711 @default.
• W2896667103 creator A5059494075 @default.
• W2896667103 creator A5075304102 @default.
• W2896667103 date "2018-10-12" @default.
• W2896667103 modified "2023-09-26" @default.
• W2896667103 title "Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest" @default.
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