Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896671004> ?p ?o ?g. }
- W2896671004 endingPage "7" @default.
- W2896671004 startingPage "1" @default.
- W2896671004 abstract "Cultivation of A549 non-small-cell lung carcinoma (NSCLC) cells in the presence of staurosporine (SSP) leads to a reduction or a lack of proliferation in a concentration-dependent manner. This inhibition of proliferation is accompanied by the generation of polyploid giant cancer cells (PGCCs) that are characterized by cell flattening, increased cell size, polyploidy, and polynucleation as determined by crystal violet staining, BrdU and DiI labelling, and flow cytometry as well as video time-lapse analysis. Continuous SSP treatment of A549 cells can preserve PGCCs for at least two months in a resting state. Upon removal of SSP, A549 PGCCs restart to divide and exhibit a proliferation pattern and cellular morphology indistinguishable from cells where PGCCs originally derived from. Thus, SSP-treated A549 cells represent a simple and reliable experimental model for the reversible generation of PGCCs and their subsequent experimental analysis." @default.
- W2896671004 created "2018-10-26" @default.
- W2896671004 creator A5012142325 @default.
- W2896671004 creator A5021771057 @default.
- W2896671004 creator A5029104997 @default.
- W2896671004 creator A5041461070 @default.
- W2896671004 creator A5059439737 @default.
- W2896671004 creator A5068992988 @default.
- W2896671004 creator A5069670782 @default.
- W2896671004 date "2018-10-10" @default.
- W2896671004 modified "2023-10-03" @default.
- W2896671004 title "Staurosporine Induces the Generation of Polyploid Giant Cancer Cells in Non-Small-Cell Lung Carcinoma A549 Cells" @default.
- W2896671004 cites W1545307478 @default.
- W2896671004 cites W1964564138 @default.
- W2896671004 cites W1987243090 @default.
- W2896671004 cites W1988212011 @default.
- W2896671004 cites W1988936955 @default.
- W2896671004 cites W2002013266 @default.
- W2896671004 cites W2025914422 @default.
- W2896671004 cites W2043617279 @default.
- W2896671004 cites W2050839463 @default.
- W2896671004 cites W2052854080 @default.
- W2896671004 cites W2055750497 @default.
- W2896671004 cites W2060631540 @default.
- W2896671004 cites W2066797624 @default.
- W2896671004 cites W2072520553 @default.
- W2896671004 cites W2079063967 @default.
- W2896671004 cites W2085210597 @default.
- W2896671004 cites W2100772783 @default.
- W2896671004 cites W2117844900 @default.
- W2896671004 cites W2167962847 @default.
- W2896671004 cites W2168458488 @default.
- W2896671004 cites W2170443235 @default.
- W2896671004 cites W2253414445 @default.
- W2896671004 cites W2505923481 @default.
- W2896671004 cites W2556373981 @default.
- W2896671004 cites W2610143972 @default.
- W2896671004 cites W2763367287 @default.
- W2896671004 cites W2951803487 @default.
- W2896671004 doi "https://doi.org/10.1155/2018/1754085" @default.
- W2896671004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199859" @default.
- W2896671004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30406001" @default.
- W2896671004 hasPublicationYear "2018" @default.
- W2896671004 type Work @default.
- W2896671004 sameAs 2896671004 @default.
- W2896671004 citedByCount "13" @default.
- W2896671004 countsByYear W28966710042019 @default.
- W2896671004 countsByYear W28966710042020 @default.
- W2896671004 countsByYear W28966710042021 @default.
- W2896671004 countsByYear W28966710042022 @default.
- W2896671004 countsByYear W28966710042023 @default.
- W2896671004 crossrefType "journal-article" @default.
- W2896671004 hasAuthorship W2896671004A5012142325 @default.
- W2896671004 hasAuthorship W2896671004A5021771057 @default.
- W2896671004 hasAuthorship W2896671004A5029104997 @default.
- W2896671004 hasAuthorship W2896671004A5041461070 @default.
- W2896671004 hasAuthorship W2896671004A5059439737 @default.
- W2896671004 hasAuthorship W2896671004A5068992988 @default.
- W2896671004 hasAuthorship W2896671004A5069670782 @default.
- W2896671004 hasBestOaLocation W28966710041 @default.
- W2896671004 hasConcept C121608353 @default.
- W2896671004 hasConcept C142724271 @default.
- W2896671004 hasConcept C1491633281 @default.
- W2896671004 hasConcept C153911025 @default.
- W2896671004 hasConcept C184235292 @default.
- W2896671004 hasConcept C195794163 @default.
- W2896671004 hasConcept C2776256026 @default.
- W2896671004 hasConcept C2779084600 @default.
- W2896671004 hasConcept C502942594 @default.
- W2896671004 hasConcept C54355233 @default.
- W2896671004 hasConcept C553184892 @default.
- W2896671004 hasConcept C55493867 @default.
- W2896671004 hasConcept C62112901 @default.
- W2896671004 hasConcept C71924100 @default.
- W2896671004 hasConcept C81729549 @default.
- W2896671004 hasConcept C86803240 @default.
- W2896671004 hasConcept C95444343 @default.
- W2896671004 hasConcept C96232424 @default.
- W2896671004 hasConceptScore W2896671004C121608353 @default.
- W2896671004 hasConceptScore W2896671004C142724271 @default.
- W2896671004 hasConceptScore W2896671004C1491633281 @default.
- W2896671004 hasConceptScore W2896671004C153911025 @default.
- W2896671004 hasConceptScore W2896671004C184235292 @default.
- W2896671004 hasConceptScore W2896671004C195794163 @default.
- W2896671004 hasConceptScore W2896671004C2776256026 @default.
- W2896671004 hasConceptScore W2896671004C2779084600 @default.
- W2896671004 hasConceptScore W2896671004C502942594 @default.
- W2896671004 hasConceptScore W2896671004C54355233 @default.
- W2896671004 hasConceptScore W2896671004C553184892 @default.
- W2896671004 hasConceptScore W2896671004C55493867 @default.
- W2896671004 hasConceptScore W2896671004C62112901 @default.
- W2896671004 hasConceptScore W2896671004C71924100 @default.
- W2896671004 hasConceptScore W2896671004C81729549 @default.
- W2896671004 hasConceptScore W2896671004C86803240 @default.
- W2896671004 hasConceptScore W2896671004C95444343 @default.
- W2896671004 hasConceptScore W2896671004C96232424 @default.
- W2896671004 hasLocation W28966710041 @default.
- W2896671004 hasLocation W28966710042 @default.