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- W2896677193 abstract "Alzheimer's disease (AD) is neuropathologically-defined as a multi-proteinopathy involving abnormally aggregated intracellular tau as neurofibrillary tangles and extracellular accumulation of amyloid-β plaques. As we move toward an era where biomarkers of amyloid, neurodegeneration, and tau are being integrated with syndromal cognitive stage, we move away from dependence on clinical presentation to define AD as recommended by the NIA-AA Research Framework. Autopsied individuals with antemortem MRI and PET imaging will be reviewed. To complement the overall session we will focus the discussion on autopsied individuals who were clinically diagnosed as AD dementia, dementia with Lewy bodies, or frontemporal dementia spectrum. Neuropathologic and neuroimaging studies have demonstrated the importance of recognizing individuals with AD whose pattern of tau pathology may diverge from what is expected based upon Braak tangle staging. These atypical AD subtypes may inform our understanding of disease progression and impact on clinical syndrome, which appears to be specific to tau and not amyloid. Given that age is the strongest risk factor for AD, we must also consider the contribution of age-related tau in astroglial (ARTAG) or argyrophilic grains disease. Moreover, the impact of the TDP-43 proteinopathy, hippocampal sclerosis, will be discussed for potential contribution to variability in neurodegeneration biomarkers. Lewy body pathology is found in more than 50% of autopsied AD cases, whereas amyloid-β plaques are found in nearly all autopsied dementia with Lewy body patients. Oppositely, frontemporal dementia cases with underlying TDP-43 for the most part lack significant amyloid-β pathology. An emphasis on this overlap of co-existing pathologies (or lack thereof) will be discussed. The cross-talk between the aerial view provided of the brain from the neuroimaging perspective and the ground-level knowledge of the neurobiology from neuropathology studies are critical toward advancing our understanding of these complex diseases." @default.
- W2896677193 created "2018-10-26" @default.
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- W2896677193 date "2018-07-01" @default.
- W2896677193 modified "2023-10-16" @default.
- W2896677193 title "F1‐01‐01: NEUROPATHOLOGIC HETEROGENEITY OF ALZHEIMER'S DISEASE AND RELATED DISORDERS" @default.
- W2896677193 doi "https://doi.org/10.1016/j.jalz.2018.06.2303" @default.
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