Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896680898> ?p ?o ?g. }
- W2896680898 endingPage "1610" @default.
- W2896680898 startingPage "1601" @default.
- W2896680898 abstract "Centenarians (CENs) are excellent subjects to study the mechanisms of human longevity and healthy aging. Here, we analyzed the transcriptomes of 76 centenarians, 54 centenarian-children, and 41 spouses of centenarian-children by RNA sequencing and found that, among the significantly differentially expressed genes (SDEGs) exhibited by CENs, the autophagy-lysosomal pathway is significantly up-regulated. Overexpression of several genes from this pathway, CTSB , ATP6V0C , ATG4D , and WIPI1 , could promote autophagy and delay senescence in cultured IMR-90 cells, while overexpression of the Drosophila homolog of WIPI1 , Atg18a , extended the life span in transgenic flies. Interestingly, the enhanced autophagy-lysosomal activity could be partially passed on to their offspring, as manifested by their higher levels of both autophagy-encoding genes and serum beclin 1 (BECN1). In light of the normal age-related decline of autophagy-lysosomal functions, these findings provide a compelling explanation for achieving longevity in, at least, female CENs, given the gender bias in our collected samples, and suggest that the enhanced waste-cleaning activity via autophagy may serve as a conserved mechanism to prolong the life span from Drosophila to humans." @default.
- W2896680898 created "2018-10-26" @default.
- W2896680898 creator A5008142824 @default.
- W2896680898 creator A5010451835 @default.
- W2896680898 creator A5012608106 @default.
- W2896680898 creator A5019120402 @default.
- W2896680898 creator A5022708066 @default.
- W2896680898 creator A5028271495 @default.
- W2896680898 creator A5031230341 @default.
- W2896680898 creator A5040404416 @default.
- W2896680898 creator A5041348573 @default.
- W2896680898 creator A5044120996 @default.
- W2896680898 creator A5057008140 @default.
- W2896680898 creator A5058268034 @default.
- W2896680898 creator A5064289105 @default.
- W2896680898 creator A5065112486 @default.
- W2896680898 creator A5076798491 @default.
- W2896680898 creator A5078949281 @default.
- W2896680898 creator A5083666748 @default.
- W2896680898 creator A5083885934 @default.
- W2896680898 creator A5091812906 @default.
- W2896680898 date "2018-10-23" @default.
- W2896680898 modified "2023-10-16" @default.
- W2896680898 title "Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians" @default.
- W2896680898 cites W1486595217 @default.
- W2896680898 cites W1631908837 @default.
- W2896680898 cites W1656781980 @default.
- W2896680898 cites W1965470471 @default.
- W2896680898 cites W1967809393 @default.
- W2896680898 cites W1970661950 @default.
- W2896680898 cites W1985308585 @default.
- W2896680898 cites W1985425785 @default.
- W2896680898 cites W1987431084 @default.
- W2896680898 cites W1987562965 @default.
- W2896680898 cites W1992933633 @default.
- W2896680898 cites W1994608257 @default.
- W2896680898 cites W2009043082 @default.
- W2896680898 cites W2010583480 @default.
- W2896680898 cites W2019755675 @default.
- W2896680898 cites W2024782183 @default.
- W2896680898 cites W2027838121 @default.
- W2896680898 cites W2038140014 @default.
- W2896680898 cites W2048109483 @default.
- W2896680898 cites W2052722944 @default.
- W2896680898 cites W2066727453 @default.
- W2896680898 cites W2080825771 @default.
- W2896680898 cites W2090239551 @default.
- W2896680898 cites W2092429129 @default.
- W2896680898 cites W2097074061 @default.
- W2896680898 cites W2107640794 @default.
- W2896680898 cites W2108700752 @default.
- W2896680898 cites W2109034822 @default.
- W2896680898 cites W2111740231 @default.
- W2896680898 cites W2112625478 @default.
- W2896680898 cites W2113466108 @default.
- W2896680898 cites W2113854409 @default.
- W2896680898 cites W2118424059 @default.
- W2896680898 cites W2130682212 @default.
- W2896680898 cites W2131271579 @default.
- W2896680898 cites W2133210805 @default.
- W2896680898 cites W2133465414 @default.
- W2896680898 cites W2136704793 @default.
- W2896680898 cites W2140729960 @default.
- W2896680898 cites W2142108845 @default.
- W2896680898 cites W2150168624 @default.
- W2896680898 cites W2158217645 @default.
- W2896680898 cites W2158804744 @default.
- W2896680898 cites W2162102563 @default.
- W2896680898 cites W2168743086 @default.
- W2896680898 cites W2169353806 @default.
- W2896680898 cites W2170551349 @default.
- W2896680898 cites W2173367702 @default.
- W2896680898 cites W2179438025 @default.
- W2896680898 cites W2290260868 @default.
- W2896680898 cites W2337055863 @default.
- W2896680898 cites W2530074591 @default.
- W2896680898 cites W2569568361 @default.
- W2896680898 cites W2583735774 @default.
- W2896680898 cites W2586476886 @default.
- W2896680898 cites W2792158423 @default.
- W2896680898 cites W2804257223 @default.
- W2896680898 cites W4238719510 @default.
- W2896680898 doi "https://doi.org/10.1101/gr.220780.117" @default.
- W2896680898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6211641" @default.
- W2896680898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30352807" @default.
- W2896680898 hasPublicationYear "2018" @default.
- W2896680898 type Work @default.
- W2896680898 sameAs 2896680898 @default.
- W2896680898 citedByCount "35" @default.
- W2896680898 countsByYear W28966808982019 @default.
- W2896680898 countsByYear W28966808982020 @default.
- W2896680898 countsByYear W28966808982021 @default.
- W2896680898 countsByYear W28966808982022 @default.
- W2896680898 countsByYear W28966808982023 @default.
- W2896680898 crossrefType "journal-article" @default.
- W2896680898 hasAuthorship W2896680898A5008142824 @default.
- W2896680898 hasAuthorship W2896680898A5010451835 @default.
- W2896680898 hasAuthorship W2896680898A5012608106 @default.