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- W2896681745 abstract "<ns4:p><ns4:bold>Background:</ns4:bold>Cases of the re-emergence of Zika virus in 2015 were associated with severe neurologic complications, including Gillien-Barre syndrome in adults and congenital Zika syndrome in newborns. The major structural determinant of immunity to the Zika virus is the E protein. Although B-cell epitopes of Zika E protein were recently identified, data regarding epitope variations among Zika strains in pre-epidemic and epidemic periods are lacking.</ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold>Here, we conducted systematic bioinformatics analyses of Zika strains isolated between 1968 and 2017. Multiple sequence alignment of E protein as well as B-cell epitopes annotations were performed. In addition, homology-based approach was utilized to construct three-dimensional structures of monomeric E glycoproteins to annotate epitope variations. Lastly, prediction of of<ns4:italic>N</ns4:italic>-glycosylation patterns and prediction of protein stability upon mutations were also investigated.</ns4:p><ns4:p><ns4:bold>Results:</ns4:bold>Our analyses indicates that epitopes recognized by human mAbs ZIKV-117, ZIKV-15, and ZIKV-19 were highly conserved, suggesting as attractive targets for the development of vaccines and immunotherapeutics directed against diverse Zika strains. In addition, the epitope recognized by ZIKV-E-2A10G6 mAb derived from immunized mice was mostly conserved across Zika strains.</ns4:p><ns4:p><ns4:bold>Conclusions:</ns4:bold>Our data provide new insights regarding antigenic similarities between Zika strains circulating worldwide. These data are essential for understanding the impact of evolution on antigenic cross-reactivity between Zika lineages and strains. Further<ns4:italic>in-vitro</ns4:italic>analyses are needed to determine how mutationsat predefined epitopes could impact the development of vaccines that can effectively neutralize Zika viruses.</ns4:p>" @default.
- W2896681745 created "2018-10-26" @default.
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- W2896681745 date "2019-06-27" @default.
- W2896681745 modified "2023-10-02" @default.
- W2896681745 title "Large-scale analysis of B-cell epitopes of envelope: Implications for Zika vaccine and immunotherapeutic development" @default.
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- W2896681745 doi "https://doi.org/10.12688/f1000research.16454.2" @default.
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