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• W2896682238 abstract "To compare the effectiveness and safety of self-expandable, sirolimus-eluting Stentys stents (SES) and second-generation drug-eluting stents (DES-II) for the treatment of the unprotected left main (ULM).SES may provide a valuable option to treat distal ULM, particularly when significant caliber gaps with side branches are observed.Patients from the multicenter SPARTA (clinicaltrials.gov: NCT02784405) and FAILS2 registries were included. Propensity-score with matching was performed to account for the lack of randomization. Primary end-point was the rate of major adverse cardiovascular events (MACE, a composite of all cause death, myocardial infarction, target lesion revascularization [TLR], unstable angina and definite stent thrombosis [ST]). Single components of MACE were the secondary end-points.Overall, 151 patients treated with SES and 1270 with DES-II were included; no differences in MACE rate at 250 days were observed (9.8% vs. 11.5%, P = 0.54). After propensity score with matching, 129 patients treated with SES and 258 with DES-II, of which about a third of female gender, were compared. After a follow-up of 250 days, MACE rate did not differ between the two groups (9.9% vs. 8.5%, P = 0.66), as well as the rate of ULM TLR (1.6% vs. 3.1%, P = 0.36) and definite ST (0.8% vs. 1.2%, P = 0.78). These results were consistent also when controlling for the treatment with provisional vs. 2-stents strategies for the ULM bifurcation.SES use for ULM treatment was associated with a similar MACE rate compared to DES-II at an intermediate-term follow-up. SES might represent a potential option in this setting." @default.
• W2896682238 created "2018-10-26" @default.
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• W2896682238 date "2018-10-08" @default.
• W2896682238 modified "2023-10-11" @default.
• W2896682238 title "Self‐expandable sirolimus‐eluting stents compared to second‐generation drug‐eluting stents for the treatment of the left main: A propensity score analysis from the SPARTA and the FAILS‐2 registries" @default.
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• W2896682238 doi "https://doi.org/10.1002/ccd.27809" @default.
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