FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896683941> ?p ?o ?g. }

• W2896683941 endingPage "709" @default.
• W2896683941 startingPage "704" @default.
• W2896683941 abstract "CshA is a DEAD-box RNA helicase that belongs to the DE x D/H-box family of proteins, which generally have an RNA-dependent ATPase activity. In Staphylococcus aureus , CshA was identified as a component of the RNA degradosome and plays important roles in RNA turnover. In this study, the crystal structures of the N-terminal RecA-like domain 1 of S. aureus CshA ( Sa CshA R1 ) and of its complex with AMP ( Sa CshA R1 –AMP) are reported at resolutions of 1.5 and 1.8 Å, respectively. Sa CshA R1 adopts a conserved α/β RecA-like structure with seven parallel strands surrounded by nine α-helices. The Q motif and motif I are responsible for the binding of the adenine group and phosphate group of AMP, respectively. Structure comparison of Sa CshA R1 –AMP and Sa CshA R1 reveals that motif I undergoes a conformational change upon AMP binding. Isothermal titration calorimetry assays further conformed the essential roles of Phe22 in the Q motif and Lys52 in motif I for binding ATP, indicating a conserved substrate-binding mechanism in Sa CshA compared with other DEAD-box RNA helicases." @default.
• W2896683941 created "2018-10-26" @default.
• W2896683941 creator A5016622484 @default.
• W2896683941 creator A5022680572 @default.
• W2896683941 creator A5034521175 @default.
• W2896683941 creator A5042319258 @default.
• W2896683941 creator A5063627915 @default.
• W2896683941 date "2018-10-16" @default.
• W2896683941 modified "2023-10-17" @default.
• W2896683941 title "Crystal structures of the N-terminal domain of the <i>Staphylococcus aureus</i> DEAD-box RNA helicase CshA and its complex with AMP" @default.
• W2896683941 cites W1539796472 @default.
• W2896683941 cites W1982042373 @default.
• W2896683941 cites W1992180542 @default.
• W2896683941 cites W1996093408 @default.
• W2896683941 cites W1996690481 @default.
• W2896683941 cites W2005913043 @default.
• W2896683941 cites W2010667362 @default.
• W2896683941 cites W2024350319 @default.
• W2896683941 cites W2024536332 @default.
• W2896683941 cites W2035595761 @default.
• W2896683941 cites W2037978116 @default.
• W2896683941 cites W2042537644 @default.
• W2896683941 cites W2051169186 @default.
• W2896683941 cites W2057259693 @default.
• W2896683941 cites W2062289554 @default.
• W2896683941 cites W2063317508 @default.
• W2896683941 cites W2088141571 @default.
• W2896683941 cites W2105439835 @default.
• W2896683941 cites W2107323746 @default.
• W2896683941 cites W2114084606 @default.
• W2896683941 cites W2122571070 @default.
• W2896683941 cites W2124026197 @default.
• W2896683941 cites W2128298547 @default.
• W2896683941 cites W2154714625 @default.
• W2896683941 cites W2159211495 @default.
• W2896683941 cites W2161406178 @default.
• W2896683941 cites W2163341755 @default.
• W2896683941 cites W2180229411 @default.
• W2896683941 cites W2513965901 @default.
• W2896683941 cites W2582852364 @default.
• W2896683941 cites W2590643905 @default.
• W2896683941 doi "https://doi.org/10.1107/s2053230x1801292x" @default.
• W2896683941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213976" @default.
• W2896683941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30387775" @default.
• W2896683941 hasPublicationYear "2018" @default.
• W2896683941 type Work @default.
• W2896683941 sameAs 2896683941 @default.
• W2896683941 citedByCount "0" @default.
• W2896683941 crossrefType "journal-article" @default.
• W2896683941 hasAuthorship W2896683941A5016622484 @default.
• W2896683941 hasAuthorship W2896683941A5022680572 @default.
• W2896683941 hasAuthorship W2896683941A5034521175 @default.
• W2896683941 hasAuthorship W2896683941A5042319258 @default.
• W2896683941 hasAuthorship W2896683941A5063627915 @default.
• W2896683941 hasBestOaLocation W28966839412 @default.
• W2896683941 hasConcept C104317684 @default.
• W2896683941 hasConcept C12554922 @default.
• W2896683941 hasConcept C132677234 @default.
• W2896683941 hasConcept C156911925 @default.
• W2896683941 hasConcept C161223559 @default.
• W2896683941 hasConcept C185592680 @default.
• W2896683941 hasConcept C2779568538 @default.
• W2896683941 hasConcept C41282012 @default.
• W2896683941 hasConcept C55493867 @default.
• W2896683941 hasConcept C67705224 @default.
• W2896683941 hasConcept C68592252 @default.
• W2896683941 hasConcept C8010536 @default.
• W2896683941 hasConcept C86803240 @default.
• W2896683941 hasConcept C95444343 @default.
• W2896683941 hasConceptScore W2896683941C104317684 @default.
• W2896683941 hasConceptScore W2896683941C12554922 @default.
• W2896683941 hasConceptScore W2896683941C132677234 @default.
• W2896683941 hasConceptScore W2896683941C156911925 @default.
• W2896683941 hasConceptScore W2896683941C161223559 @default.
• W2896683941 hasConceptScore W2896683941C185592680 @default.
• W2896683941 hasConceptScore W2896683941C2779568538 @default.
• W2896683941 hasConceptScore W2896683941C41282012 @default.
• W2896683941 hasConceptScore W2896683941C55493867 @default.
• W2896683941 hasConceptScore W2896683941C67705224 @default.
• W2896683941 hasConceptScore W2896683941C68592252 @default.
• W2896683941 hasConceptScore W2896683941C8010536 @default.
• W2896683941 hasConceptScore W2896683941C86803240 @default.
• W2896683941 hasConceptScore W2896683941C95444343 @default.
• W2896683941 hasFunder F4320321001 @default.
• W2896683941 hasFunder F4320321133 @default.
• W2896683941 hasFunder F4320334897 @default.
• W2896683941 hasFunder F4320335777 @default.
• W2896683941 hasIssue "11" @default.
• W2896683941 hasLocation W28966839411 @default.
• W2896683941 hasLocation W28966839412 @default.
• W2896683941 hasLocation W28966839413 @default.
• W2896683941 hasOpenAccess W2896683941 @default.
• W2896683941 hasPrimaryLocation W28966839411 @default.
• W2896683941 hasRelatedWork W1977912125 @default.
• W2896683941 hasRelatedWork W2005512596 @default.
• W2896683941 hasRelatedWork W2021567743 @default.
• W2896683941 hasRelatedWork W2023651356 @default.
• W2896683941 hasRelatedWork W2032827720 @default.

• next