Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896685722> ?p ?o ?g. }
- W2896685722 abstract "Remyelination is critical for nerve regeneration. However, the molecular mechanism involved in remyelination is poorly understood. To explore the roles of 17β-estradiol (E2) for myelination in the peripheral nervous system, we used a co-culture model of rat dorsal root ganglion (DRG) explants and Schwann cells (SCs) and a regeneration model of the crushed sciatic nerves in ovariectomized (OVX) and non-ovariectomized (non-OVX) rats for in vitro and in vivo analysis. E2 promoted myelination by facilitating the differentiation of SCs in vitro, which could be inhibited by the estrogen receptors (ER) antagonist ICI182780, ERβ antagonist PHTPP, or ERK1/2 antagonist PD98059. This suggests that E2 accelerates SC differentiation via the ERβ-ERK1/2 signaling. Furthermore, E2 promotes remyelination in crushed sciatic nerves of both OVX and non-OVX rats. Interestingly, E2 also significantly increased the expression of the lysosome membrane proteins LAMP1 and myelin protein P0 in the regenerating nerves. Moreover, P0 has higher degree of colocalization with LAMP1 in the regenerating nerves. Taking together, our results suggest that E2 enhances Schwann cell differentiation and further myelination via the ERβ-ERK1/2 signaling and that E2 increases the expression of myelin proteins and lysosomes in SCs to promotes remyelination in regenerating sciatic nerves." @default.
- W2896685722 created "2018-10-26" @default.
- W2896685722 creator A5018271028 @default.
- W2896685722 creator A5019429833 @default.
- W2896685722 creator A5019906052 @default.
- W2896685722 creator A5030166798 @default.
- W2896685722 creator A5035139835 @default.
- W2896685722 creator A5060347417 @default.
- W2896685722 creator A5062581280 @default.
- W2896685722 creator A5078490250 @default.
- W2896685722 creator A5087683362 @default.
- W2896685722 creator A5091226105 @default.
- W2896685722 date "2018-10-09" @default.
- W2896685722 modified "2023-10-14" @default.
- W2896685722 title "17β-Estradiol Enhances Schwann Cell Differentiation via the ERβ-ERK1/2 Signaling Pathway and Promotes Remyelination in Injured Sciatic Nerves" @default.
- W2896685722 cites W1572154272 @default.
- W2896685722 cites W1974638429 @default.
- W2896685722 cites W1978266038 @default.
- W2896685722 cites W1984841297 @default.
- W2896685722 cites W1987647696 @default.
- W2896685722 cites W1989317027 @default.
- W2896685722 cites W1992699495 @default.
- W2896685722 cites W2005884759 @default.
- W2896685722 cites W2030496214 @default.
- W2896685722 cites W2032151432 @default.
- W2896685722 cites W2033545707 @default.
- W2896685722 cites W2038408869 @default.
- W2896685722 cites W2045072541 @default.
- W2896685722 cites W2050278057 @default.
- W2896685722 cites W2050410777 @default.
- W2896685722 cites W2061310823 @default.
- W2896685722 cites W2064248618 @default.
- W2896685722 cites W2064888696 @default.
- W2896685722 cites W2075911174 @default.
- W2896685722 cites W2079823127 @default.
- W2896685722 cites W2083229277 @default.
- W2896685722 cites W2083537177 @default.
- W2896685722 cites W2086534450 @default.
- W2896685722 cites W2095833455 @default.
- W2896685722 cites W2098152470 @default.
- W2896685722 cites W2099878230 @default.
- W2896685722 cites W2107360339 @default.
- W2896685722 cites W2119504151 @default.
- W2896685722 cites W2132043124 @default.
- W2896685722 cites W2138046729 @default.
- W2896685722 cites W2218134682 @default.
- W2896685722 cites W2292591575 @default.
- W2896685722 cites W2404170115 @default.
- W2896685722 cites W2473882857 @default.
- W2896685722 cites W2545075063 @default.
- W2896685722 cites W2578885464 @default.
- W2896685722 cites W4211044652 @default.
- W2896685722 doi "https://doi.org/10.3389/fphar.2018.01026" @default.
- W2896685722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189327" @default.
- W2896685722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30356713" @default.
- W2896685722 hasPublicationYear "2018" @default.
- W2896685722 type Work @default.
- W2896685722 sameAs 2896685722 @default.
- W2896685722 citedByCount "13" @default.
- W2896685722 countsByYear W28966857222019 @default.
- W2896685722 countsByYear W28966857222020 @default.
- W2896685722 countsByYear W28966857222021 @default.
- W2896685722 countsByYear W28966857222022 @default.
- W2896685722 countsByYear W28966857222023 @default.
- W2896685722 crossrefType "journal-article" @default.
- W2896685722 hasAuthorship W2896685722A5018271028 @default.
- W2896685722 hasAuthorship W2896685722A5019429833 @default.
- W2896685722 hasAuthorship W2896685722A5019906052 @default.
- W2896685722 hasAuthorship W2896685722A5030166798 @default.
- W2896685722 hasAuthorship W2896685722A5035139835 @default.
- W2896685722 hasAuthorship W2896685722A5060347417 @default.
- W2896685722 hasAuthorship W2896685722A5062581280 @default.
- W2896685722 hasAuthorship W2896685722A5078490250 @default.
- W2896685722 hasAuthorship W2896685722A5087683362 @default.
- W2896685722 hasAuthorship W2896685722A5091226105 @default.
- W2896685722 hasBestOaLocation W28966857221 @default.
- W2896685722 hasConcept C126322002 @default.
- W2896685722 hasConcept C134018914 @default.
- W2896685722 hasConcept C169760540 @default.
- W2896685722 hasConcept C171056886 @default.
- W2896685722 hasConcept C185592680 @default.
- W2896685722 hasConcept C2777004073 @default.
- W2896685722 hasConcept C2777619251 @default.
- W2896685722 hasConcept C2778609137 @default.
- W2896685722 hasConcept C2781149210 @default.
- W2896685722 hasConcept C529278444 @default.
- W2896685722 hasConcept C71924100 @default.
- W2896685722 hasConcept C86803240 @default.
- W2896685722 hasConcept C95444343 @default.
- W2896685722 hasConceptScore W2896685722C126322002 @default.
- W2896685722 hasConceptScore W2896685722C134018914 @default.
- W2896685722 hasConceptScore W2896685722C169760540 @default.
- W2896685722 hasConceptScore W2896685722C171056886 @default.
- W2896685722 hasConceptScore W2896685722C185592680 @default.
- W2896685722 hasConceptScore W2896685722C2777004073 @default.
- W2896685722 hasConceptScore W2896685722C2777619251 @default.
- W2896685722 hasConceptScore W2896685722C2778609137 @default.
- W2896685722 hasConceptScore W2896685722C2781149210 @default.
- W2896685722 hasConceptScore W2896685722C529278444 @default.
- W2896685722 hasConceptScore W2896685722C71924100 @default.