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• W2896688539 endingPage "1229" @default.
• W2896688539 startingPage "1219" @default.
• W2896688539 abstract "Radical cystectomy is the standard therapy for patients with muscle-invasive bladder cancer. Organ-preserving surgical procedures have been established as alternatives to radical surgery for localized malignancies in other anatomic sites. Trimodal therapy consisting of radiation therapy, chemotherapy, and either transurethral resection of the bladder or partial cystectomy is an effective treatment for selected patients with muscle-invasive bladder cancer that allows for preservation of the urinary bladder. Areas covered: This review provides an overview of the value of trimodal therapy in the treatment of muscle-invasive bladder cancer. Expert commentary: Prerequisites for trimodal therapy for bladder cancer include: good bladder function, unifocal cT2 urothelial carcinoma of the bladder, and absence of hydronephrosis. Careful selection of patients and accurate assessment of the anatomic extent of the tumor is important for patient safety. The basis for successful trimodal therapy is complete transurethral resection of the tumor, followed by radiation therapy with concurrent radiosensitizing chemotherapy. Cystoscopic controls and follow-up biopsies should be performed at completion of adjuvant therapy or shortly after induction of trimodal therapy to identify nonresponders for whom salvage radical cystectomy may be indicated." @default.
• W2896688539 created "2018-10-26" @default.
• W2896688539 creator A5042022681 @default.
• W2896688539 creator A5043800833 @default.
• W2896688539 creator A5072818969 @default.
• W2896688539 creator A5086583298 @default.
• W2896688539 date "2018-10-17" @default.
• W2896688539 modified "2023-09-24" @default.
• W2896688539 title "Trimodal therapy for muscle-invasive bladder cancer" @default.
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