Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896690111> ?p ?o ?g. }
- W2896690111 abstract "Abstract Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe 3+ and Cu 2+ ions to facilitate metal-ion uptake by mammalian cells. STEAPs are highly upregulated in several types of cancer, making them potential therapeutic targets. However, the structural basis for STEAP-catalyzed electron transfer through an array of cofactors to metals at the membrane luminal side remains elusive. Here, we report cryo-electron microscopy structures of human STEAP4 in absence and presence of Fe 3+ -NTA. Domain-swapped, trimeric STEAP4 orients NADPH bound to a cytosolic domain onto axially aligned flavin-adenine dinucleotide (FAD) and a single b-type heme that cross the transmembrane-domain to enable electron transfer. Substrate binding within a positively charged ring indicates that iron gets reduced while in complex with its chelator. These molecular principles of iron reduction provide a basis for exploring STEAPs as therapeutic targets." @default.
- W2896690111 created "2018-10-26" @default.
- W2896690111 creator A5017449175 @default.
- W2896690111 creator A5028840022 @default.
- W2896690111 creator A5045574506 @default.
- W2896690111 creator A5045835186 @default.
- W2896690111 creator A5064939031 @default.
- W2896690111 creator A5073848521 @default.
- W2896690111 creator A5081201438 @default.
- W2896690111 date "2018-10-18" @default.
- W2896690111 modified "2023-10-18" @default.
- W2896690111 title "Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction" @default.
- W2896690111 cites W1520601156 @default.
- W2896690111 cites W1982295411 @default.
- W2896690111 cites W1987008536 @default.
- W2896690111 cites W2001904774 @default.
- W2896690111 cites W2002381200 @default.
- W2896690111 cites W2008499168 @default.
- W2896690111 cites W2024076139 @default.
- W2896690111 cites W2034502536 @default.
- W2896690111 cites W2035816996 @default.
- W2896690111 cites W2047399603 @default.
- W2896690111 cites W2062107099 @default.
- W2896690111 cites W2064140868 @default.
- W2896690111 cites W2064702079 @default.
- W2896690111 cites W2069774708 @default.
- W2896690111 cites W2070164943 @default.
- W2896690111 cites W2076840886 @default.
- W2896690111 cites W2081082399 @default.
- W2896690111 cites W2084428683 @default.
- W2896690111 cites W2089374576 @default.
- W2896690111 cites W2089429067 @default.
- W2896690111 cites W2095216354 @default.
- W2896690111 cites W2097025305 @default.
- W2896690111 cites W2104234755 @default.
- W2896690111 cites W2107959310 @default.
- W2896690111 cites W2109184569 @default.
- W2896690111 cites W2120396539 @default.
- W2896690111 cites W2124246500 @default.
- W2896690111 cites W2125108879 @default.
- W2896690111 cites W2134888531 @default.
- W2896690111 cites W2144081223 @default.
- W2896690111 cites W2151460907 @default.
- W2896690111 cites W2152562710 @default.
- W2896690111 cites W2158314006 @default.
- W2896690111 cites W2162746575 @default.
- W2896690111 cites W2165565773 @default.
- W2896690111 cites W2169547796 @default.
- W2896690111 cites W2285171927 @default.
- W2896690111 cites W2542964897 @default.
- W2896690111 cites W2587625522 @default.
- W2896690111 cites W2593511418 @default.
- W2896690111 cites W2600862990 @default.
- W2896690111 cites W2626208092 @default.
- W2896690111 cites W2765107560 @default.
- W2896690111 cites W2793257932 @default.
- W2896690111 cites W2950967305 @default.
- W2896690111 doi "https://doi.org/10.1038/s41467-018-06817-7" @default.
- W2896690111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6194020" @default.
- W2896690111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30337524" @default.
- W2896690111 hasPublicationYear "2018" @default.
- W2896690111 type Work @default.
- W2896690111 sameAs 2896690111 @default.
- W2896690111 citedByCount "31" @default.
- W2896690111 countsByYear W28966901112019 @default.
- W2896690111 countsByYear W28966901112020 @default.
- W2896690111 countsByYear W28966901112021 @default.
- W2896690111 countsByYear W28966901112022 @default.
- W2896690111 countsByYear W28966901112023 @default.
- W2896690111 crossrefType "journal-article" @default.
- W2896690111 hasAuthorship W2896690111A5017449175 @default.
- W2896690111 hasAuthorship W2896690111A5028840022 @default.
- W2896690111 hasAuthorship W2896690111A5045574506 @default.
- W2896690111 hasAuthorship W2896690111A5045835186 @default.
- W2896690111 hasAuthorship W2896690111A5064939031 @default.
- W2896690111 hasAuthorship W2896690111A5073848521 @default.
- W2896690111 hasAuthorship W2896690111A5081201438 @default.
- W2896690111 hasBestOaLocation W28966901111 @default.
- W2896690111 hasConcept C118892022 @default.
- W2896690111 hasConcept C123669783 @default.
- W2896690111 hasConcept C12554922 @default.
- W2896690111 hasConcept C170493617 @default.
- W2896690111 hasConcept C181199279 @default.
- W2896690111 hasConcept C185592680 @default.
- W2896690111 hasConcept C197957613 @default.
- W2896690111 hasConcept C21951064 @default.
- W2896690111 hasConcept C24530287 @default.
- W2896690111 hasConcept C2775859393 @default.
- W2896690111 hasConcept C33093398 @default.
- W2896690111 hasConcept C41625074 @default.
- W2896690111 hasConcept C55493867 @default.
- W2896690111 hasConcept C75473681 @default.
- W2896690111 hasConcept C79879829 @default.
- W2896690111 hasConcept C86803240 @default.
- W2896690111 hasConcept C98539663 @default.
- W2896690111 hasConceptScore W2896690111C118892022 @default.
- W2896690111 hasConceptScore W2896690111C123669783 @default.
- W2896690111 hasConceptScore W2896690111C12554922 @default.
- W2896690111 hasConceptScore W2896690111C170493617 @default.
- W2896690111 hasConceptScore W2896690111C181199279 @default.