FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896691640> ?p ?o ?g. }

• W2896691640 endingPage "2034" @default.
• W2896691640 startingPage "2019" @default.
• W2896691640 abstract "Summary Objective To determine when spontaneous granule cell epileptiform discharges first occur after hippocampal injury, and to identify the postinjury “latent” period as either a “silent” gestational state of epileptogenesis or a subtle epileptic state in gradual transition to a more obvious epileptic state. Methods Nonconvulsive status epilepticus evoked by perforant path stimulation in urethane‐sedated rats produced selective and extensive hippocampal injury and a “latent” period that preceded the onset of the first clinically obvious epileptic seizures. Continuous granule cell layer depth recording and video monitoring assessed the time course of granule cell hyperexcitability and the onset/offset times of spontaneous epileptiform discharges and behavioral seizures. Results One day postinjury, granule cells in awake rats were hyperexcitable to afferent input, and continuously generated spontaneous population spikes. During the ~2‐4 week “latent” period, granule cell epileptiform discharges lasting ~30 seconds caused subtle focal seizures characterized by immobilization and facial automatisms that were undetected by behavioral assessment alone but identified post hoc. Granule cell layer epileptiform discharge duration eventually tripled, which caused the first clinically obvious seizure, ending the “latent” period. Behavioral seizure duration was linked tightly to spontaneous granule cell layer events. Granule cell epileptiform discharges preceded all behavioral seizure onsets, and clonic behaviors ended abruptly within seconds of the termination of each granule cell epileptiform discharge. Noninjurious hippocampal excitation produced no evidence of granule cell hyperexcitability or epileptogenesis. Significance The latent period in this model is a subtle epileptic state in transition to a more clinically obvious epileptic state, not a seizure‐free “gestational” state when an unidentified epileptogenic mechanism gradually develops. Based on the onset/offset times of electrographic and behavioral events, granule cell behavior may be the prime determinant of seizure onset, phenotype, duration, and offset in this model of hippocampal‐onset epilepsy. Extensive hippocampal neuron loss could be the primary epileptogenic mechanism." @default.
• W2896691640 created "2018-10-26" @default.
• W2896691640 creator A5040955318 @default.
• W2896691640 creator A5089634192 @default.
• W2896691640 date "2018-10-19" @default.
• W2896691640 modified "2023-09-27" @default.
• W2896691640 title "No latency to dentate granule cell epileptogenesis in experimental temporal lobe epilepsy with hippocampal sclerosis" @default.
• W2896691640 cites W1487386905 @default.
• W2896691640 cites W1696288187 @default.
• W2896691640 cites W1723579215 @default.
• W2896691640 cites W1880320779 @default.
• W2896691640 cites W1906116459 @default.
• W2896691640 cites W1965911702 @default.
• W2896691640 cites W1965953789 @default.
• W2896691640 cites W1971678045 @default.
• W2896691640 cites W1975012184 @default.
• W2896691640 cites W1975357199 @default.
• W2896691640 cites W1987313743 @default.
• W2896691640 cites W1996285727 @default.
• W2896691640 cites W1999220095 @default.
• W2896691640 cites W2006878775 @default.
• W2896691640 cites W2007191899 @default.
• W2896691640 cites W2010425177 @default.
• W2896691640 cites W2017083014 @default.
• W2896691640 cites W2017239156 @default.
• W2896691640 cites W2019836893 @default.
• W2896691640 cites W2022637923 @default.
• W2896691640 cites W2024645270 @default.
• W2896691640 cites W2031575360 @default.
• W2896691640 cites W2033065960 @default.
• W2896691640 cites W2035862839 @default.
• W2896691640 cites W2038026687 @default.
• W2896691640 cites W2051064821 @default.
• W2896691640 cites W2051866494 @default.
• W2896691640 cites W2059658339 @default.
• W2896691640 cites W2067446126 @default.
• W2896691640 cites W2081319561 @default.
• W2896691640 cites W2086267716 @default.
• W2896691640 cites W2087164479 @default.
• W2896691640 cites W2087291581 @default.
• W2896691640 cites W2088188719 @default.
• W2896691640 cites W2095906091 @default.
• W2896691640 cites W2103946141 @default.
• W2896691640 cites W2119124441 @default.
• W2896691640 cites W2132239248 @default.
• W2896691640 cites W2150310369 @default.
• W2896691640 cites W2150936467 @default.
• W2896691640 cites W2156806480 @default.
• W2896691640 cites W2165827907 @default.
• W2896691640 cites W2173317214 @default.
• W2896691640 cites W2743912370 @default.
• W2896691640 cites W2796424949 @default.
• W2896691640 doi "https://doi.org/10.1111/epi.14580" @default.
• W2896691640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30338519" @default.
• W2896691640 hasPublicationYear "2018" @default.
• W2896691640 type Work @default.
• W2896691640 sameAs 2896691640 @default.
• W2896691640 citedByCount "18" @default.
• W2896691640 countsByYear W28966916402018 @default.
• W2896691640 countsByYear W28966916402019 @default.
• W2896691640 countsByYear W28966916402020 @default.
• W2896691640 countsByYear W28966916402021 @default.
• W2896691640 countsByYear W28966916402022 @default.
• W2896691640 countsByYear W28966916402023 @default.
• W2896691640 crossrefType "journal-article" @default.
• W2896691640 hasAuthorship W2896691640A5040955318 @default.
• W2896691640 hasAuthorship W2896691640A5089634192 @default.
• W2896691640 hasBestOaLocation W28966916401 @default.
• W2896691640 hasConcept C148762608 @default.
• W2896691640 hasConcept C15744967 @default.
• W2896691640 hasConcept C169760540 @default.
• W2896691640 hasConcept C2776168963 @default.
• W2896691640 hasConcept C2776464000 @default.
• W2896691640 hasConcept C2777341932 @default.
• W2896691640 hasConcept C2777597344 @default.
• W2896691640 hasConcept C2778186239 @default.
• W2896691640 hasConcept C2778888523 @default.
• W2896691640 hasConcept C2781099131 @default.
• W2896691640 hasConcept C42219234 @default.
• W2896691640 hasConcept C57236427 @default.
• W2896691640 hasConcept C71924100 @default.
• W2896691640 hasConceptScore W2896691640C148762608 @default.
• W2896691640 hasConceptScore W2896691640C15744967 @default.
• W2896691640 hasConceptScore W2896691640C169760540 @default.
• W2896691640 hasConceptScore W2896691640C2776168963 @default.
• W2896691640 hasConceptScore W2896691640C2776464000 @default.
• W2896691640 hasConceptScore W2896691640C2777341932 @default.
• W2896691640 hasConceptScore W2896691640C2777597344 @default.
• W2896691640 hasConceptScore W2896691640C2778186239 @default.
• W2896691640 hasConceptScore W2896691640C2778888523 @default.
• W2896691640 hasConceptScore W2896691640C2781099131 @default.
• W2896691640 hasConceptScore W2896691640C42219234 @default.
• W2896691640 hasConceptScore W2896691640C57236427 @default.
• W2896691640 hasConceptScore W2896691640C71924100 @default.
• W2896691640 hasFunder F4320337359 @default.
• W2896691640 hasIssue "11" @default.
• W2896691640 hasLocation W28966916401 @default.
• W2896691640 hasLocation W28966916402 @default.

• next