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• W2896693618 abstract "Abstract MYD88 mutations are one of the most recurrent mutations in hematologic malignancies. However, recent mouse models suggest that MYD88 L265P alone may not be sufficient to induce tumor formation. Interplay between MYD88 L265P and other genetic events is further supported by the fact that TNFAIP3 (A20) inactivation often accompanies MYD88 L265P . However, we are still lacking information about the consequence of MYD88 L265P in combination with TNFAIP3 loss in human B cell lymphoma. Review of our genetic data on diffuse large B cell lymphoma (DLBCL) and Waldenstrom macroglobulinemia (WM), found that a large percentage of DLBCL and WM cases that have a MYD88 mutation also harbor a TNFAIP3 loss, 55% DLBCL and 28% of WM, respectively. To mimic this combination of genetic events, we used genomic editing technology to knock out TNFAIP3 in MYD88 L265P non-Hodgkin’s lymphoma (NHL) cell lines. Loss of A20 expression resulted in increased NF-κB and p38 activity leading to upregulation of the NF-κB target genes BCL2 and MYC . Furthermore, we detected the increased production of IL-6 and CXCL10 which led to an upregulation of the JAK/STAT pathway. Overall, these results suggest that MYD88 L265P signaling can be enhanced by a second genetic alteration in TNFAIP3 and highlights a potential opportunity for therapeutic targeting." @default.
• W2896693618 created "2018-10-26" @default.
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• W2896693618 date "2018-10-09" @default.
• W2896693618 modified "2023-10-15" @default.
• W2896693618 title "Loss of TNFAIP3 enhances MYD88L265P-driven signaling in non-Hodgkin lymphoma" @default.
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• W2896693618 cites W1992325820 @default.
• W2896693618 cites W1997867127 @default.
• W2896693618 cites W2001131160 @default.
• W2896693618 cites W2004739040 @default.
• W2896693618 cites W2008760557 @default.
• W2896693618 cites W2020781390 @default.
• W2896693618 cites W2021472989 @default.
• W2896693618 cites W2021536610 @default.
• W2896693618 cites W2027931900 @default.
• W2896693618 cites W2027943626 @default.
• W2896693618 cites W2033823335 @default.
• W2896693618 cites W2035135710 @default.
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• W2896693618 cites W2043398720 @default.
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• W2896693618 cites W2056641238 @default.
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• W2896693618 cites W2068343048 @default.
• W2896693618 cites W2070217465 @default.
• W2896693618 cites W2086144234 @default.
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• W2896693618 cites W2110053604 @default.
• W2896693618 cites W2110474703 @default.
• W2896693618 cites W2116126605 @default.
• W2896693618 cites W2116382435 @default.
• W2896693618 cites W2119050380 @default.
• W2896693618 cites W2123160735 @default.
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• W2896693618 cites W2158267770 @default.
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• W2896693618 cites W2347186599 @default.
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• W2896693618 cites W2591243927 @default.
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• W2896693618 doi "https://doi.org/10.1038/s41408-018-0130-3" @default.
• W2896693618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6177394" @default.
• W2896693618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301877" @default.
• W2896693618 hasPublicationYear "2018" @default.
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