FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896695019> ?p ?o ?g. }

• W2896695019 abstract "Imaging the aging brain is often challenging. Older individuals are more likely to have conditions that limit scanner time, motion can be more pronounced, and image contrast within brain tissue changes with age. fMRI scanning in older individuals is also challenging. In addition to external contributors to signal disruption such as motion and dental structures, we also observe other patterns of signal dropout in our older participants. fMRI EPI scans (3T Philips scanner) collected in 270 older participants (mean age=76.3 yrs) in the Baltimore Longitudinal Study of Aging (BLSA) were visually reviewed for areas of signal dropout. MPRAGE structural scans collected during the same session were then reviewed to determine anatomic sources of the fMRI signal disruption. Signal intensity levels within the basal ganglia (BG) were also extracted and assessed. The most common areas of signal disruption occurred in the BG (72% of participants), superior midline regions (7%), frontal pole (4%), medial frontal cortex (3%) and cerebellum (2%). 12% of individuals had signal disruption in >1 region, and only 24% were without any signal disruption. Although the BOLD signal was negatively correlated with age in the BG, there were no consistent anatomic abnormalities observed, suggesting that signal dropout may be related to iron accumulation with advancing age. Those who were noted to have BG signal dropout had significantly lower signal intensity in the caudate, putamen and globus pallidus relative to those who appeared normal. Superior midline and medial frontal dropout was usually related to midline hyperintensities located within the falx cerebri, and frontal pole issues were related to large frontal sinuses. Cerebellar signal dropout occurred within deep cerebellar nuclei. These signal disruptions were maintained in the fMRI images after stereotactic normalization, but were less apparent after smoothing. A majority of older individuals exhibit some form of fMRI signal disruption. The most common area of signal loss occurred in the BG, followed by midline and frontal pole regions. These findings highlight the importance of visual review of fMRI scans in older populations, especially for experiments designed to examine brain function in regions where signal disruption commonly occurs." @default.
• W2896695019 created "2018-10-26" @default.
• W2896695019 creator A5003112344 @default.
• W2896695019 creator A5015502914 @default.
• W2896695019 creator A5037961149 @default.
• W2896695019 creator A5043413645 @default.
• W2896695019 creator A5090514483 @default.
• W2896695019 date "2018-07-01" @default.
• W2896695019 modified "2023-10-12" @default.
• W2896695019 title "IC‐P‐117: FMRI AND THE AGING BRAIN: COMMON AREAS OF SIGNAL DISRUPTION IN AN OLDER POPULATION" @default.
• W2896695019 doi "https://doi.org/10.1016/j.jalz.2018.06.2183" @default.
• W2896695019 hasPublicationYear "2018" @default.
• W2896695019 type Work @default.
• W2896695019 sameAs 2896695019 @default.
• W2896695019 citedByCount "0" @default.
• W2896695019 crossrefType "journal-article" @default.
• W2896695019 hasAuthorship W2896695019A5003112344 @default.
• W2896695019 hasAuthorship W2896695019A5015502914 @default.
• W2896695019 hasAuthorship W2896695019A5037961149 @default.
• W2896695019 hasAuthorship W2896695019A5043413645 @default.
• W2896695019 hasAuthorship W2896695019A5090514483 @default.
• W2896695019 hasConcept C126838900 @default.
• W2896695019 hasConcept C143409427 @default.
• W2896695019 hasConcept C15744967 @default.
• W2896695019 hasConcept C169760540 @default.
• W2896695019 hasConcept C2777127467 @default.
• W2896695019 hasConcept C2778187257 @default.
• W2896695019 hasConcept C2779714222 @default.
• W2896695019 hasConcept C2780278869 @default.
• W2896695019 hasConcept C2908647359 @default.
• W2896695019 hasConcept C529278444 @default.
• W2896695019 hasConcept C548259974 @default.
• W2896695019 hasConcept C71924100 @default.
• W2896695019 hasConcept C99454951 @default.
• W2896695019 hasConceptScore W2896695019C126838900 @default.
• W2896695019 hasConceptScore W2896695019C143409427 @default.
• W2896695019 hasConceptScore W2896695019C15744967 @default.
• W2896695019 hasConceptScore W2896695019C169760540 @default.
• W2896695019 hasConceptScore W2896695019C2777127467 @default.
• W2896695019 hasConceptScore W2896695019C2778187257 @default.
• W2896695019 hasConceptScore W2896695019C2779714222 @default.
• W2896695019 hasConceptScore W2896695019C2780278869 @default.
• W2896695019 hasConceptScore W2896695019C2908647359 @default.
• W2896695019 hasConceptScore W2896695019C529278444 @default.
• W2896695019 hasConceptScore W2896695019C548259974 @default.
• W2896695019 hasConceptScore W2896695019C71924100 @default.
• W2896695019 hasConceptScore W2896695019C99454951 @default.
• W2896695019 hasIssue "7S_Part_2" @default.
• W2896695019 hasLocation W28966950191 @default.
• W2896695019 hasOpenAccess W2896695019 @default.
• W2896695019 hasPrimaryLocation W28966950191 @default.
• W2896695019 hasRelatedWork W161201599 @default.
• W2896695019 hasRelatedWork W1872183301 @default.
• W2896695019 hasRelatedWork W194430627 @default.
• W2896695019 hasRelatedWork W1980558642 @default.
• W2896695019 hasRelatedWork W2132636956 @default.
• W2896695019 hasRelatedWork W2132748306 @default.
• W2896695019 hasRelatedWork W2162561353 @default.
• W2896695019 hasRelatedWork W2190703979 @default.
• W2896695019 hasRelatedWork W3030121363 @default.
• W2896695019 hasRelatedWork W55748174 @default.
• W2896695019 hasVolume "14" @default.
• W2896695019 isParatext "false" @default.
• W2896695019 isRetracted "false" @default.
• W2896695019 magId "2896695019" @default.
• W2896695019 workType "article" @default.