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• W2896697539 abstract "Expansion of the polyglutamine (polyQ) tract in exon 1 of the huntingtin protein (Httex1) leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains poorly understood how polyQ expansions alter protein structure and cause toxicity. Using CD, EPR, and NMR spectroscopy, we found here that monomeric Httex1 consists of two co-existing structural states whose ratio is determined by polyQ tract length. We observed that short Q-lengths favor a largely random-coil state, whereas long Q-lengths increase the proportion of a predominantly α-helical state. We also note that by following a mobility gradient, Httex1 α-helical conformation is restricted to the N-terminal N17 region and to the N-terminal portion of the adjoining polyQ tract. Structuring in both regions was interdependent and likely stabilized by tertiary contacts. Although little helicity was present in N17 alone, each Gln residue in Httex1 enhanced helix stability by 0.03–0.05 kcal/mol, causing a pronounced preference for the α-helical state at pathological Q-lengths. The Q-length–dependent structuring and rigidification could be mimicked in proteins with shorter Q-lengths by a decrease in temperature, indicating that lower temperatures similarly stabilize N17 and polyQ intramolecular contacts. The more rigid α-helical state of Httex1 with an expanded polyQ tract is expected to alter interactions with cellular proteins and modulate the toxic Httex1 misfolding process. We propose that the polyQ-dependent shift in the structural equilibrium may enable future therapeutic strategies that specifically target Httex1 with toxic Q-lengths." @default.
• W2896697539 created "2018-10-26" @default.
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• W2896697539 date "2018-12-01" @default.
• W2896697539 modified "2023-10-18" @default.
• W2896697539 title "The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract" @default.
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• W2896697539 doi "https://doi.org/10.1074/jbc.ra118.004808" @default.
• W2896697539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6314148" @default.
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