FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896710631> ?p ?o ?g. }

• W2896710631 abstract "Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumourigenesis and development. Although the low expression of miR-125a-5p in non-small-cell lung cancer (NSCLC) has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in NSCLC was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the CpG island in the miR-125a-5p region was hypermethylated in the tumour tissues, and the hypermethylation was negatively correlated with miR-125a-5p expression. Target gene screening showed that the histone methyltransferase Suv39H1 was one of the potential target genes. In vitro studies showed that miR-125a-5p could directly suppress Suv39H1 expression and decrease the H3K9me3 levels. On the other hand, Suv39H1 could induce demethylation of miR-125a-5p, resulting in re-activation of miR-125a-5p. What is more, overexpessing miR-125a-5p could also self-activate the silenced miR-125a-5p in NSCLC cells, which suppressed cell migration, invasion and proliferation in vitro and inhibited cancer progression in vivo . Thus, we found that the epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in NSCLC, suggesting that miR-125a-5p might not only have the potential prognostic value as a tumour biomarker but also be a potential therapeutic target in NSCLC." @default.
• W2896710631 created "2018-10-26" @default.
• W2896710631 creator A5001215093 @default.
• W2896710631 creator A5014394467 @default.
• W2896710631 creator A5044501118 @default.
• W2896710631 creator A5052650725 @default.
• W2896710631 creator A5084201050 @default.
• W2896710631 date "2018-10-01" @default.
• W2896710631 modified "2023-09-27" @default.
• W2896710631 title "RETRACTED: Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression" @default.
• W2896710631 cites W1593660812 @default.
• W2896710631 cites W1791729203 @default.
• W2896710631 cites W1958510895 @default.
• W2896710631 cites W1991667131 @default.
• W2896710631 cites W1998651094 @default.
• W2896710631 cites W1998780829 @default.
• W2896710631 cites W2001453032 @default.
• W2896710631 cites W2009205164 @default.
• W2896710631 cites W2010667036 @default.
• W2896710631 cites W2022637871 @default.
• W2896710631 cites W2038585848 @default.
• W2896710631 cites W2039309920 @default.
• W2896710631 cites W2102381062 @default.
• W2896710631 cites W2106787323 @default.
• W2896710631 cites W2114047398 @default.
• W2896710631 cites W2119283268 @default.
• W2896710631 cites W2127300984 @default.
• W2896710631 cites W2200502704 @default.
• W2896710631 cites W2235523093 @default.
• W2896710631 cites W2235994213 @default.
• W2896710631 cites W2251552368 @default.
• W2896710631 cites W2431543454 @default.
• W2896710631 cites W2542315333 @default.
• W2896710631 cites W2588025094 @default.
• W2896710631 cites W2620438284 @default.
• W2896710631 cites W2728598631 @default.
• W2896710631 cites W2772269131 @default.
• W2896710631 cites W2915478882 @default.
• W2896710631 cites W3154088065 @default.
• W2896710631 doi "https://doi.org/10.1098/rsob.180118" @default.
• W2896710631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6223209" @default.
• W2896710631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305431" @default.
• W2896710631 hasPublicationYear "2018" @default.
• W2896710631 type Work @default.
• W2896710631 sameAs 2896710631 @default.
• W2896710631 citedByCount "16" @default.
• W2896710631 countsByYear W28967106312019 @default.
• W2896710631 countsByYear W28967106312020 @default.
• W2896710631 countsByYear W28967106312021 @default.
• W2896710631 countsByYear W28967106312022 @default.
• W2896710631 countsByYear W28967106312023 @default.
• W2896710631 crossrefType "journal-article" @default.
• W2896710631 hasAuthorship W2896710631A5001215093 @default.
• W2896710631 hasAuthorship W2896710631A5014394467 @default.
• W2896710631 hasAuthorship W2896710631A5044501118 @default.
• W2896710631 hasAuthorship W2896710631A5052650725 @default.
• W2896710631 hasAuthorship W2896710631A5084201050 @default.
• W2896710631 hasBestOaLocation W28967106311 @default.
• W2896710631 hasConcept C104317684 @default.
• W2896710631 hasConcept C121608353 @default.
• W2896710631 hasConcept C143998085 @default.
• W2896710631 hasConcept C145059251 @default.
• W2896710631 hasConcept C150194340 @default.
• W2896710631 hasConcept C190727270 @default.
• W2896710631 hasConcept C2776256026 @default.
• W2896710631 hasConcept C2780737395 @default.
• W2896710631 hasConcept C33288867 @default.
• W2896710631 hasConcept C41091548 @default.
• W2896710631 hasConcept C502942594 @default.
• W2896710631 hasConcept C54355233 @default.
• W2896710631 hasConcept C555283112 @default.
• W2896710631 hasConcept C62112901 @default.
• W2896710631 hasConcept C71924100 @default.
• W2896710631 hasConcept C86803240 @default.
• W2896710631 hasConcept C91965660 @default.
• W2896710631 hasConceptScore W2896710631C104317684 @default.
• W2896710631 hasConceptScore W2896710631C121608353 @default.
• W2896710631 hasConceptScore W2896710631C143998085 @default.
• W2896710631 hasConceptScore W2896710631C145059251 @default.
• W2896710631 hasConceptScore W2896710631C150194340 @default.
• W2896710631 hasConceptScore W2896710631C190727270 @default.
• W2896710631 hasConceptScore W2896710631C2776256026 @default.
• W2896710631 hasConceptScore W2896710631C2780737395 @default.
• W2896710631 hasConceptScore W2896710631C33288867 @default.
• W2896710631 hasConceptScore W2896710631C41091548 @default.
• W2896710631 hasConceptScore W2896710631C502942594 @default.
• W2896710631 hasConceptScore W2896710631C54355233 @default.
• W2896710631 hasConceptScore W2896710631C555283112 @default.
• W2896710631 hasConceptScore W2896710631C62112901 @default.
• W2896710631 hasConceptScore W2896710631C71924100 @default.
• W2896710631 hasConceptScore W2896710631C86803240 @default.
• W2896710631 hasConceptScore W2896710631C91965660 @default.
• W2896710631 hasIssue "10" @default.
• W2896710631 hasLocation W28967106311 @default.
• W2896710631 hasLocation W28967106312 @default.
• W2896710631 hasLocation W28967106313 @default.
• W2896710631 hasLocation W28967106314 @default.
• W2896710631 hasOpenAccess W2896710631 @default.
• W2896710631 hasPrimaryLocation W28967106311 @default.
• W2896710631 hasRelatedWork W1978665041 @default.

• next