Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896710973> ?p ?o ?g. }
- W2896710973 abstract "Long noncoding RNAs (lncRNAs) are non-protein coding transcripts that are involved in a broad range of biological processes. Here, we examined the functional roles of lncRNAs in feather regeneration. RNA-seq profiling of the regenerating feather blastema revealed that the Wnt signaling is among the most active pathways during feather regeneration, with the Wnt ligands and their inhibitors showing distinct expression patterns. Co-expression analysis identified hundreds of lncRNAs with similar expression patterns to either the Wnt ligands (the Lwnt group) or their downstream target genes (the Twnt group). Among these, we randomly picked two lncRNAs in the Lwnt group, and three lncRNAs in the Twnt group to validate their expression and function. Members in the Twnt group regulated feather regeneration and axis formation, whereas members in the Lwnt group showed no obvious phenotype. Further analysis confirmed that the three Twnt group members inhibit Wnt signal transduction and at the same time are down-stream target genes of this pathway. Our results suggested that the feather regeneration model can be utilized to systematically annotate the functions of lncRNAs in the chicken genome." @default.
- W2896710973 created "2018-10-26" @default.
- W2896710973 creator A5010094101 @default.
- W2896710973 creator A5017933207 @default.
- W2896710973 creator A5045754647 @default.
- W2896710973 creator A5048306560 @default.
- W2896710973 creator A5062700484 @default.
- W2896710973 creator A5074033491 @default.
- W2896710973 creator A5087199806 @default.
- W2896710973 date "2018-01-01" @default.
- W2896710973 modified "2023-10-15" @default.
- W2896710973 title "Long noncoding RNAs regulate Wnt signaling during feather regeneration" @default.
- W2896710973 cites W1156445109 @default.
- W2896710973 cites W1970741980 @default.
- W2896710973 cites W1972440741 @default.
- W2896710973 cites W1976859420 @default.
- W2896710973 cites W1977093862 @default.
- W2896710973 cites W1978001117 @default.
- W2896710973 cites W1978586737 @default.
- W2896710973 cites W1993574813 @default.
- W2896710973 cites W1996207018 @default.
- W2896710973 cites W1996915466 @default.
- W2896710973 cites W2005977856 @default.
- W2896710973 cites W2010019056 @default.
- W2896710973 cites W2019477867 @default.
- W2896710973 cites W2024791799 @default.
- W2896710973 cites W2032183472 @default.
- W2896710973 cites W2035423713 @default.
- W2896710973 cites W2035862141 @default.
- W2896710973 cites W2044039680 @default.
- W2896710973 cites W2044311442 @default.
- W2896710973 cites W2046381665 @default.
- W2896710973 cites W2056982373 @default.
- W2896710973 cites W2061522141 @default.
- W2896710973 cites W2068517905 @default.
- W2896710973 cites W2086901023 @default.
- W2896710973 cites W2092004042 @default.
- W2896710973 cites W2101142880 @default.
- W2896710973 cites W2102313656 @default.
- W2896710973 cites W2106142873 @default.
- W2896710973 cites W2136583460 @default.
- W2896710973 cites W2138370010 @default.
- W2896710973 cites W2142019735 @default.
- W2896710973 cites W2163802438 @default.
- W2896710973 cites W2169777381 @default.
- W2896710973 cites W2174181728 @default.
- W2896710973 cites W2297193872 @default.
- W2896710973 cites W2507402545 @default.
- W2896710973 cites W2547268814 @default.
- W2896710973 cites W2585873586 @default.
- W2896710973 cites W2586305898 @default.
- W2896710973 cites W2588513721 @default.
- W2896710973 cites W2598871689 @default.
- W2896710973 cites W2601961147 @default.
- W2896710973 cites W2606172339 @default.
- W2896710973 cites W2607321273 @default.
- W2896710973 cites W2607796168 @default.
- W2896710973 cites W2615993640 @default.
- W2896710973 cites W2748457537 @default.
- W2896710973 cites W2750249030 @default.
- W2896710973 cites W2750468899 @default.
- W2896710973 cites W2783079550 @default.
- W2896710973 cites W2787867074 @default.
- W2896710973 cites W2797365125 @default.
- W2896710973 cites W2806959289 @default.
- W2896710973 cites W2810283585 @default.
- W2896710973 cites W2885095792 @default.
- W2896710973 doi "https://doi.org/10.1242/dev.162388" @default.
- W2896710973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30327322" @default.
- W2896710973 hasPublicationYear "2018" @default.
- W2896710973 type Work @default.
- W2896710973 sameAs 2896710973 @default.
- W2896710973 citedByCount "6" @default.
- W2896710973 countsByYear W28967109732020 @default.
- W2896710973 countsByYear W28967109732021 @default.
- W2896710973 countsByYear W28967109732022 @default.
- W2896710973 countsByYear W28967109732023 @default.
- W2896710973 crossrefType "journal-article" @default.
- W2896710973 hasAuthorship W2896710973A5010094101 @default.
- W2896710973 hasAuthorship W2896710973A5017933207 @default.
- W2896710973 hasAuthorship W2896710973A5045754647 @default.
- W2896710973 hasAuthorship W2896710973A5048306560 @default.
- W2896710973 hasAuthorship W2896710973A5062700484 @default.
- W2896710973 hasAuthorship W2896710973A5074033491 @default.
- W2896710973 hasAuthorship W2896710973A5087199806 @default.
- W2896710973 hasBestOaLocation W28967109731 @default.
- W2896710973 hasConcept C104317684 @default.
- W2896710973 hasConcept C127716648 @default.
- W2896710973 hasConcept C127745971 @default.
- W2896710973 hasConcept C137620995 @default.
- W2896710973 hasConcept C171056886 @default.
- W2896710973 hasConcept C54355233 @default.
- W2896710973 hasConcept C62203573 @default.
- W2896710973 hasConcept C62478195 @default.
- W2896710973 hasConcept C67705224 @default.
- W2896710973 hasConcept C70721500 @default.
- W2896710973 hasConcept C78214289 @default.
- W2896710973 hasConcept C86803240 @default.
- W2896710973 hasConcept C90856448 @default.
- W2896710973 hasConcept C95444343 @default.