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• W2896711065 abstract "Patients with diabetes are at significantly higher risk of developing heart failure. Increases in advanced glycation end products are a proposed pathophysiological link, but their impact and mechanism remain incompletely understood. Methylglyoxal (MG) is a glycolysis byproduct, elevated in diabetes, and modifies arginine and lysine residues. We show that left ventricular myofilament from patients with diabetes and heart failure (dbHF) exhibited increased MG modifications compared with nonfailing controls (NF) or heart failure patients without diabetes. In skinned NF human and mouse cardiomyocytes, acute MG treatment depressed both calcium sensitivity and maximal calcium-activated force in a dose-dependent manner. Importantly, dbHF myocytes were resistant to myofilament functional changes from MG treatment, indicating that myofilaments from dbHF patients already had depressed function arising from MG modifications. In human dbHF and MG-treated mice, mass spectrometry identified increased MG modifications on actin and myosin. Cosedimentation and in vitro motility assays indicate that MG modifications on actin and myosin independently depress calcium sensitivity, and mechanistically, the functional consequence requires actin/myosin interaction with thin-filament regulatory proteins. MG modification of the myofilament may represent a critical mechanism by which diabetes induces heart failure, as well as a therapeutic target to avoid the development of or ameliorate heart failure in these patients." @default.
• W2896711065 created "2018-10-26" @default.
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• W2896711065 date "2018-10-18" @default.
• W2896711065 modified "2023-10-16" @default.
• W2896711065 title "Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function" @default.
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• W2896711065 doi "https://doi.org/10.1172/jci.insight.121264" @default.
• W2896711065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237482" @default.
• W2896711065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30333300" @default.
• W2896711065 hasPublicationYear "2018" @default.
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