FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896713706> ?p ?o ?g. }

• W2896713706 endingPage "178" @default.
• W2896713706 startingPage "171" @default.
• W2896713706 abstract "Objectives: Paclitaxel (Ptx) has been regarded as one of the most effective chemotherapeutic drugs for lung cancers. Increasing studies focused on the nano-delivery system of Ptx due to its poor solubility and hypersensitivity. The aim of the recent study was to investigate the antitumor effects of self-assembled Ptx nano-filaments for lung cancer cells. </P><P> Methods: In the present study, we designed and synthesized novel Ptx-loaded nano-filaments through conjugation of Ptx and succinic acid (SA) (Ptx-SA, P-NFs). Non-small cell lung cancer (NSCLC) A549 and H460 cells were used for detecting the antitumor effects of P-NFs, including cytotoxicity, apoptosis, and migration. Western blotting was performed for analyzing mechanism. Results: P-NFs nano-filaments exerted superior antitumor effects against NSCLC cells compared with free Ptx using cytotoxicity tests. Furthermore, P-NFs nano-filaments were much more effective in inducing NSCLC cells apoptosis and inhibiting A549 cells migration than free Ptx. To elucidate the underlying mechanisms, the expression of apoptotic and endoplasmic reticulum (ER) stress proteins was detected. The results indicated that P-NFs nano-filaments enhanced the expression of bax/bcl-2, protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1&#945; (IRE1&#945;), phospho- c-Jun N-terminal kinase (p-JNK), and C/EPB homologous protein (CHOP), which suggested that the strong antitumor effect of P-NFs nano-filaments may be partially attributed to the activation ER stress. The current work demonstrated that P-NFs nano-filaments showed superior cytotoxicity of lung cancer cells, highlighting a novel profile of nano-filaments delivery systems as potential strategies for facilitating the therapeutic efficacy of Ptx in lung cancer treatment." @default.
• W2896713706 created "2018-10-26" @default.
• W2896713706 creator A5006697419 @default.
• W2896713706 creator A5006824735 @default.
• W2896713706 creator A5027264714 @default.
• W2896713706 creator A5031979422 @default.
• W2896713706 creator A5070164923 @default.
• W2896713706 creator A5074026124 @default.
• W2896713706 creator A5075079503 @default.
• W2896713706 date "2018-12-14" @default.
• W2896713706 modified "2023-10-12" @default.
• W2896713706 title "The Superior Antitumor Effect of Self-Assembled Paclitaxel Nanofilaments for Lung Cancer Cells" @default.
• W2896713706 cites W2007946604 @default.
• W2896713706 cites W2012166934 @default.
• W2896713706 cites W2017322644 @default.
• W2896713706 cites W2025997346 @default.
• W2896713706 cites W2050696182 @default.
• W2896713706 cites W2063953032 @default.
• W2896713706 cites W2070805871 @default.
• W2896713706 cites W2074471441 @default.
• W2896713706 cites W2076886472 @default.
• W2896713706 cites W2080901528 @default.
• W2896713706 cites W2095133247 @default.
• W2896713706 cites W2104970490 @default.
• W2896713706 cites W2115307546 @default.
• W2896713706 cites W2139568257 @default.
• W2896713706 cites W2140671259 @default.
• W2896713706 cites W2150048195 @default.
• W2896713706 cites W2162969910 @default.
• W2896713706 cites W2184694295 @default.
• W2896713706 cites W2217904475 @default.
• W2896713706 cites W2273495465 @default.
• W2896713706 cites W2402118151 @default.
• W2896713706 cites W2408471207 @default.
• W2896713706 cites W2413313836 @default.
• W2896713706 cites W2495036908 @default.
• W2896713706 cites W2523360988 @default.
• W2896713706 cites W2564665116 @default.
• W2896713706 cites W2588675203 @default.
• W2896713706 cites W2608026191 @default.
• W2896713706 cites W2610303739 @default.
• W2896713706 cites W2621502726 @default.
• W2896713706 cites W2738920954 @default.
• W2896713706 cites W2739922721 @default.
• W2896713706 cites W2762595071 @default.
• W2896713706 cites W2783531699 @default.
• W2896713706 cites W2790707780 @default.
• W2896713706 cites W2792115410 @default.
• W2896713706 cites W2793152198 @default.
• W2896713706 cites W2794041650 @default.
• W2896713706 cites W2795020867 @default.
• W2896713706 doi "https://doi.org/10.2174/1567201815666181017094003" @default.
• W2896713706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30332958" @default.
• W2896713706 hasPublicationYear "2018" @default.
• W2896713706 type Work @default.
• W2896713706 sameAs 2896713706 @default.
• W2896713706 citedByCount "3" @default.
• W2896713706 countsByYear W28967137062021 @default.
• W2896713706 countsByYear W28967137062022 @default.
• W2896713706 crossrefType "journal-article" @default.
• W2896713706 hasAuthorship W2896713706A5006697419 @default.
• W2896713706 hasAuthorship W2896713706A5006824735 @default.
• W2896713706 hasAuthorship W2896713706A5027264714 @default.
• W2896713706 hasAuthorship W2896713706A5031979422 @default.
• W2896713706 hasAuthorship W2896713706A5070164923 @default.
• W2896713706 hasAuthorship W2896713706A5074026124 @default.
• W2896713706 hasAuthorship W2896713706A5075079503 @default.
• W2896713706 hasConcept C109316439 @default.
• W2896713706 hasConcept C121608353 @default.
• W2896713706 hasConcept C126322002 @default.
• W2896713706 hasConcept C158617107 @default.
• W2896713706 hasConcept C184235292 @default.
• W2896713706 hasConcept C185592680 @default.
• W2896713706 hasConcept C190283241 @default.
• W2896713706 hasConcept C202751555 @default.
• W2896713706 hasConcept C2776694085 @default.
• W2896713706 hasConcept C2777292972 @default.
• W2896713706 hasConcept C2778239845 @default.
• W2896713706 hasConcept C2779725641 @default.
• W2896713706 hasConcept C502942594 @default.
• W2896713706 hasConcept C55493867 @default.
• W2896713706 hasConcept C71924100 @default.
• W2896713706 hasConcept C81729549 @default.
• W2896713706 hasConcept C86803240 @default.
• W2896713706 hasConcept C95444343 @default.
• W2896713706 hasConcept C96232424 @default.
• W2896713706 hasConceptScore W2896713706C109316439 @default.
• W2896713706 hasConceptScore W2896713706C121608353 @default.
• W2896713706 hasConceptScore W2896713706C126322002 @default.
• W2896713706 hasConceptScore W2896713706C158617107 @default.
• W2896713706 hasConceptScore W2896713706C184235292 @default.
• W2896713706 hasConceptScore W2896713706C185592680 @default.
• W2896713706 hasConceptScore W2896713706C190283241 @default.
• W2896713706 hasConceptScore W2896713706C202751555 @default.
• W2896713706 hasConceptScore W2896713706C2776694085 @default.
• W2896713706 hasConceptScore W2896713706C2777292972 @default.
• W2896713706 hasConceptScore W2896713706C2778239845 @default.
• W2896713706 hasConceptScore W2896713706C2779725641 @default.

• next