FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896714478> ?p ?o ?g. }

• W2896714478 endingPage "1089" @default.
• W2896714478 startingPage "1081" @default.
• W2896714478 abstract "There are several options available for intravenous application of iron supplements, but they all have a similar structure:—an iron core surrounded by a carbohydrate coating. These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. This process risks exposing cells and tissues to free iron, which is potentially toxic due to its high redox activity. A new parenteral iron formation, ferric pyrophosphate citrate (FPC), has a novel structure that differs from conventional intravenous iron formulations, consisting of an iron atom complexed to one pyrophosphate and two citrate anions. In this study, we show that FPC can directly transfer iron to apo-transferrin. Kinetic analyses reveal that FPC donates iron to apo-transferrin with fast binding kinetics. In addition, the crystal structure of transferrin bound to FPC shows that FPC can donate iron to both iron-binding sites found within the transferrin structure. Examination of the iron-binding sites demonstrates that the iron atoms in both sites are fully encapsulated, forming bonds with amino acid side chains in the protein as well as pyrophosphate and carbonate anions. Taken together, these data demonstrate that, unlike intravenous iron formulations, FPC can directly and rapidly donate iron to transferrin in a manner that does not expose cells and tissues to the damaging effects of free, redox-active iron." @default.
• W2896714478 created "2018-10-26" @default.
• W2896714478 creator A5006004732 @default.
• W2896714478 creator A5054501791 @default.
• W2896714478 creator A5061605775 @default.
• W2896714478 creator A5069331466 @default.
• W2896714478 date "2018-10-11" @default.
• W2896714478 modified "2023-10-17" @default.
• W2896714478 title "Ferric pyrophosphate citrate: interactions with transferrin" @default.
• W2896714478 cites W1494785820 @default.
• W2896714478 cites W1551307287 @default.
• W2896714478 cites W1560264875 @default.
• W2896714478 cites W1587187427 @default.
• W2896714478 cites W1651040627 @default.
• W2896714478 cites W1966189550 @default.
• W2896714478 cites W1967017135 @default.
• W2896714478 cites W1982346357 @default.
• W2896714478 cites W1992177979 @default.
• W2896714478 cites W1996280964 @default.
• W2896714478 cites W2019583561 @default.
• W2896714478 cites W2022306017 @default.
• W2896714478 cites W2031639364 @default.
• W2896714478 cites W2044728822 @default.
• W2896714478 cites W2052881431 @default.
• W2896714478 cites W2057328273 @default.
• W2896714478 cites W2059778114 @default.
• W2896714478 cites W2068337287 @default.
• W2896714478 cites W2073759014 @default.
• W2896714478 cites W2083963729 @default.
• W2896714478 cites W2090296940 @default.
• W2896714478 cites W2091266084 @default.
• W2896714478 cites W2094737738 @default.
• W2896714478 cites W2109184569 @default.
• W2896714478 cites W2117354944 @default.
• W2896714478 cites W2141387019 @default.
• W2896714478 cites W2141986488 @default.
• W2896714478 cites W2144081223 @default.
• W2896714478 cites W2154714625 @default.
• W2896714478 cites W2159211495 @default.
• W2896714478 cites W2163341755 @default.
• W2896714478 cites W2170163556 @default.
• W2896714478 cites W2179278454 @default.
• W2896714478 cites W2300586950 @default.
• W2896714478 cites W2338266315 @default.
• W2896714478 cites W2340183923 @default.
• W2896714478 cites W2406984260 @default.
• W2896714478 cites W2509762573 @default.
• W2896714478 cites W2772585576 @default.
• W2896714478 cites W4248872320 @default.
• W2896714478 doi "https://doi.org/10.1007/s10534-018-0142-2" @default.
• W2896714478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6245029" @default.
• W2896714478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30311019" @default.
• W2896714478 hasPublicationYear "2018" @default.
• W2896714478 type Work @default.
• W2896714478 sameAs 2896714478 @default.
• W2896714478 citedByCount "15" @default.
• W2896714478 countsByYear W28967144782019 @default.
• W2896714478 countsByYear W28967144782020 @default.
• W2896714478 countsByYear W28967144782021 @default.
• W2896714478 countsByYear W28967144782022 @default.
• W2896714478 countsByYear W28967144782023 @default.
• W2896714478 crossrefType "journal-article" @default.
• W2896714478 hasAuthorship W2896714478A5006004732 @default.
• W2896714478 hasAuthorship W2896714478A5054501791 @default.
• W2896714478 hasAuthorship W2896714478A5061605775 @default.
• W2896714478 hasAuthorship W2896714478A5069331466 @default.
• W2896714478 hasBestOaLocation W28967144781 @default.
• W2896714478 hasConcept C12554922 @default.
• W2896714478 hasConcept C179104552 @default.
• W2896714478 hasConcept C181199279 @default.
• W2896714478 hasConcept C185592680 @default.
• W2896714478 hasConcept C22814914 @default.
• W2896714478 hasConcept C2776043855 @default.
• W2896714478 hasConcept C2780534640 @default.
• W2896714478 hasConcept C55493867 @default.
• W2896714478 hasConcept C55904794 @default.
• W2896714478 hasConcept C86803240 @default.
• W2896714478 hasConceptScore W2896714478C12554922 @default.
• W2896714478 hasConceptScore W2896714478C179104552 @default.
• W2896714478 hasConceptScore W2896714478C181199279 @default.
• W2896714478 hasConceptScore W2896714478C185592680 @default.
• W2896714478 hasConceptScore W2896714478C22814914 @default.
• W2896714478 hasConceptScore W2896714478C2776043855 @default.
• W2896714478 hasConceptScore W2896714478C2780534640 @default.
• W2896714478 hasConceptScore W2896714478C55493867 @default.
• W2896714478 hasConceptScore W2896714478C55904794 @default.
• W2896714478 hasConceptScore W2896714478C86803240 @default.
• W2896714478 hasIssue "6" @default.
• W2896714478 hasLocation W28967144781 @default.
• W2896714478 hasLocation W28967144782 @default.
• W2896714478 hasLocation W28967144783 @default.
• W2896714478 hasLocation W28967144784 @default.
• W2896714478 hasOpenAccess W2896714478 @default.
• W2896714478 hasPrimaryLocation W28967144781 @default.
• W2896714478 hasRelatedWork W1503297619 @default.
• W2896714478 hasRelatedWork W1982346357 @default.
• W2896714478 hasRelatedWork W1999310862 @default.
• W2896714478 hasRelatedWork W2008106512 @default.

• next