FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896718406> ?p ?o ?g. }

• W2896718406 endingPage "599" @default.
• W2896718406 startingPage "588" @default.
• W2896718406 abstract "Adenosine triphosphate-binding cassette (ABC) transporters, including P-glycoprotein (Pgp) and multi-resistance associated proteins (Mrps), have been considered important participants in the self-protection of zebrafish embryos against environmental pollutants, but their possible involvement in the efflux and detoxification of quantum dots (QDs), as well as their regulation mechanism are currently unclear. In this work, gene expression alterations of ABC transporters, nuclear receptors, and oxidative stress signaling in zebrafish embryos after the treatment of mercaptopropionic acid (MPA)CdTe QDs and MPA-CdSCdTe QDs were investigated. It was observed that both QDs caused concentration-dependent delayed hatching effects and the subsequent induction of transporters like mrp1&2 in zebrafish embryos, indicating the protective role of corresponding proteins against CdTe QDs. Accompanying these alterations, expressions of nuclear receptors including the pregnane X receptor (pxr), aryl hydrocarbon receptor (ahr) 1b, and peroxisome proliferator-activated receptor (ppar)-β were induced by QDs in a concentration- and time-dependent manner. Moreover, elevated oxidative stress, reflected by the reduction of glutathione (GSH) level and superoxide dismutase (SOD) activities, as well as the dramatic induction of nuclear factor E2 related factor (nrf) 2, was also found. More importantly, alterations of pxr and nrf2 were more pronounced than that of mrps, and these receptors exhibited an excellent correlation with delayed hatching rate in the same embryos (R2 > 0.8). Results from this analysis demonstrated that the induction of mrp1 and mrp2 could be important components for the detoxification of QDs in zebrafish embryos. These transporters could be modulated by nuclear receptors and oxidative stress signaling. In addition, up-regulation of pxr and nrf2 could be developed as toxic biomarkers of CdTe QDs." @default.
• W2896718406 created "2018-10-26" @default.
• W2896718406 creator A5000882678 @default.
• W2896718406 creator A5008284058 @default.
• W2896718406 creator A5020517880 @default.
• W2896718406 creator A5022489785 @default.
• W2896718406 creator A5040387071 @default.
• W2896718406 creator A5046115138 @default.
• W2896718406 creator A5056062141 @default.
• W2896718406 creator A5073236513 @default.
• W2896718406 date "2019-01-01" @default.
• W2896718406 modified "2023-10-16" @default.
• W2896718406 title "Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots" @default.
• W2896718406 cites W1565139562 @default.
• W2896718406 cites W1974373425 @default.
• W2896718406 cites W1974435871 @default.
• W2896718406 cites W1979504061 @default.
• W2896718406 cites W1980370917 @default.
• W2896718406 cites W2012128752 @default.
• W2896718406 cites W2016590530 @default.
• W2896718406 cites W2024647684 @default.
• W2896718406 cites W2028612768 @default.
• W2896718406 cites W2032921798 @default.
• W2896718406 cites W2061879307 @default.
• W2896718406 cites W2080447877 @default.
• W2896718406 cites W2083618110 @default.
• W2896718406 cites W2099575771 @default.
• W2896718406 cites W2116903726 @default.
• W2896718406 cites W2122044425 @default.
• W2896718406 cites W2149783560 @default.
• W2896718406 cites W2157393167 @default.
• W2896718406 cites W2162155594 @default.
• W2896718406 cites W2163279678 @default.
• W2896718406 cites W2291145159 @default.
• W2896718406 cites W2295281563 @default.
• W2896718406 cites W2334889346 @default.
• W2896718406 cites W2345123291 @default.
• W2896718406 cites W2463992495 @default.
• W2896718406 cites W2494917950 @default.
• W2896718406 cites W2569484861 @default.
• W2896718406 cites W2578118892 @default.
• W2896718406 cites W2582109398 @default.
• W2896718406 cites W2582585325 @default.
• W2896718406 cites W2593347693 @default.
• W2896718406 cites W2593846452 @default.
• W2896718406 cites W2605441944 @default.
• W2896718406 cites W2609888017 @default.
• W2896718406 cites W2618072336 @default.
• W2896718406 cites W2740839736 @default.
• W2896718406 cites W2744632091 @default.
• W2896718406 cites W2760006740 @default.
• W2896718406 cites W2766958672 @default.
• W2896718406 cites W2779755522 @default.
• W2896718406 cites W2792451260 @default.
• W2896718406 cites W805945966 @default.
• W2896718406 cites W84544081 @default.
• W2896718406 doi "https://doi.org/10.1016/j.envpol.2018.10.092" @default.
• W2896718406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30384064" @default.
• W2896718406 hasPublicationYear "2019" @default.
• W2896718406 type Work @default.
• W2896718406 sameAs 2896718406 @default.
• W2896718406 citedByCount "34" @default.
• W2896718406 countsByYear W28967184062019 @default.
• W2896718406 countsByYear W28967184062020 @default.
• W2896718406 countsByYear W28967184062021 @default.
• W2896718406 countsByYear W28967184062022 @default.
• W2896718406 countsByYear W28967184062023 @default.
• W2896718406 crossrefType "journal-article" @default.
• W2896718406 hasAuthorship W2896718406A5000882678 @default.
• W2896718406 hasAuthorship W2896718406A5008284058 @default.
• W2896718406 hasAuthorship W2896718406A5020517880 @default.
• W2896718406 hasAuthorship W2896718406A5022489785 @default.
• W2896718406 hasAuthorship W2896718406A5040387071 @default.
• W2896718406 hasAuthorship W2896718406A5046115138 @default.
• W2896718406 hasAuthorship W2896718406A5056062141 @default.
• W2896718406 hasAuthorship W2896718406A5073236513 @default.
• W2896718406 hasConcept C104317684 @default.
• W2896718406 hasConcept C132040763 @default.
• W2896718406 hasConcept C149011108 @default.
• W2896718406 hasConcept C170493617 @default.
• W2896718406 hasConcept C181199279 @default.
• W2896718406 hasConcept C185592680 @default.
• W2896718406 hasConcept C2776151105 @default.
• W2896718406 hasConcept C2776878037 @default.
• W2896718406 hasConcept C33594762 @default.
• W2896718406 hasConcept C44312359 @default.
• W2896718406 hasConcept C538909803 @default.
• W2896718406 hasConcept C55493867 @default.
• W2896718406 hasConcept C63932345 @default.
• W2896718406 hasConcept C86339819 @default.
• W2896718406 hasConcept C86803240 @default.
• W2896718406 hasConcept C95444343 @default.
• W2896718406 hasConceptScore W2896718406C104317684 @default.
• W2896718406 hasConceptScore W2896718406C132040763 @default.
• W2896718406 hasConceptScore W2896718406C149011108 @default.
• W2896718406 hasConceptScore W2896718406C170493617 @default.
• W2896718406 hasConceptScore W2896718406C181199279 @default.
• W2896718406 hasConceptScore W2896718406C185592680 @default.

• next