FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896721276> ?p ?o ?g. }

• W2896721276 abstract "Esophageal squamous cell carcinoma (ESCC) is one of the aggressive malignancies and mechanisms underlying its pathogenesis remain unclear. Cyclooxygenase-2 (COX-2) enzyme system plays a crucial role in many gastrointestinal malignancies and is an important regulator of cell growth, proliferation, apoptosis, differentiation and transformation. More precise outcome of COX-2 in ESCC is less investigated. In this study we investigated the risk factors of ESCC and expression of COX-2 in Carcinoma in situ (CIS) and ESCC compared to normal esophageal mucosa. ESCC relationship to clinico-pathological parameters using immunohistochemistry was also part of this investigation. Current study was conducted in the Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. A total of 69 diagnosed patients of ESCC, both Pakistanis and Afghans were enrolled. Various risk factors associated with ESCC were recorded. Mean age at the time of diagnosis was 55 years. Out of 69 patients of ESCC 46 (67%) were users of dipping tobacco (Naswar). Expression of COX-2 was determined in normal esophageal mucosa, CIS and invasive ESCC using Immunohistochemistry (IHC). Differences of mean were computed using ANOVA followed by applying Post Hoc test. Patients were categorized as positive with high expression or negative with low to nil expression. ANOVA showed large differences in expression of COX-2 in normal healthy mucosa compared with CIS and ESCC with the mean difference of -9.529 and -7.370 respectively, p-value being <.05 at 95% confidence interval (CI). No significant difference was noticed in the expression of COX-2 in CIS compared with ESCC with p-value >.05 at 95% CI. Our complete cohort (23-85 years) showed statistically significant difference in the expression of COX-2 gene in ESCC and CIS tissue samples compared with normal healthy mucosa. Results of this study indicate that over-expression of COX-2 is positively associated with ESCC." @default.
• W2896721276 created "2018-10-26" @default.
• W2896721276 creator A5016248155 @default.
• W2896721276 creator A5016493113 @default.
• W2896721276 creator A5022156956 @default.
• W2896721276 creator A5049770908 @default.
• W2896721276 creator A5068070077 @default.
• W2896721276 creator A5074335603 @default.
• W2896721276 date "2018-10-19" @default.
• W2896721276 modified "2023-09-27" @default.
• W2896721276 title "Expression analysis of cyclooxygenase-2 in patients suffering from esophageal squamous cell carcinoma" @default.
• W2896721276 cites W1503322305 @default.
• W2896721276 cites W159592000 @default.
• W2896721276 cites W1863328694 @default.
• W2896721276 cites W1977378512 @default.
• W2896721276 cites W1984355255 @default.
• W2896721276 cites W1988948521 @default.
• W2896721276 cites W1995423152 @default.
• W2896721276 cites W2004995987 @default.
• W2896721276 cites W2005475775 @default.
• W2896721276 cites W2005512270 @default.
• W2896721276 cites W2010993902 @default.
• W2896721276 cites W2012320279 @default.
• W2896721276 cites W2040143851 @default.
• W2896721276 cites W2056308227 @default.
• W2896721276 cites W2057282881 @default.
• W2896721276 cites W2063209855 @default.
• W2896721276 cites W2064606403 @default.
• W2896721276 cites W2074329828 @default.
• W2896721276 cites W2097364840 @default.
• W2896721276 cites W2099119591 @default.
• W2896721276 cites W2099526120 @default.
• W2896721276 cites W2111627225 @default.
• W2896721276 cites W2127624057 @default.
• W2896721276 cites W2132988098 @default.
• W2896721276 cites W2137415149 @default.
• W2896721276 cites W2140293241 @default.
• W2896721276 cites W2142628421 @default.
• W2896721276 cites W2143263295 @default.
• W2896721276 cites W2150512905 @default.
• W2896721276 cites W2162517111 @default.
• W2896721276 cites W21735425 @default.
• W2896721276 cites W2279030367 @default.
• W2896721276 cites W2735556877 @default.
• W2896721276 cites W2735791491 @default.
• W2896721276 cites W335531720 @default.
• W2896721276 cites W4300624582 @default.
• W2896721276 doi "https://doi.org/10.1371/journal.pone.0205508" @default.
• W2896721276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195262" @default.
• W2896721276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30339710" @default.
• W2896721276 hasPublicationYear "2018" @default.
• W2896721276 type Work @default.
• W2896721276 sameAs 2896721276 @default.
• W2896721276 citedByCount "4" @default.
• W2896721276 countsByYear W28967212762020 @default.
• W2896721276 countsByYear W28967212762021 @default.
• W2896721276 countsByYear W28967212762023 @default.
• W2896721276 crossrefType "journal-article" @default.
• W2896721276 hasAuthorship W2896721276A5016248155 @default.
• W2896721276 hasAuthorship W2896721276A5016493113 @default.
• W2896721276 hasAuthorship W2896721276A5022156956 @default.
• W2896721276 hasAuthorship W2896721276A5049770908 @default.
• W2896721276 hasAuthorship W2896721276A5068070077 @default.
• W2896721276 hasAuthorship W2896721276A5074335603 @default.
• W2896721276 hasBestOaLocation W28967212761 @default.
• W2896721276 hasConcept C126322002 @default.
• W2896721276 hasConcept C142724271 @default.
• W2896721276 hasConcept C143998085 @default.
• W2896721276 hasConcept C181199279 @default.
• W2896721276 hasConcept C190283241 @default.
• W2896721276 hasConcept C204232928 @default.
• W2896721276 hasConcept C207886595 @default.
• W2896721276 hasConcept C2777546739 @default.
• W2896721276 hasConcept C2779689624 @default.
• W2896721276 hasConcept C2994415158 @default.
• W2896721276 hasConcept C44249647 @default.
• W2896721276 hasConcept C50382708 @default.
• W2896721276 hasConcept C55493867 @default.
• W2896721276 hasConcept C67761136 @default.
• W2896721276 hasConcept C71924100 @default.
• W2896721276 hasConcept C86803240 @default.
• W2896721276 hasConcept C90924648 @default.
• W2896721276 hasConceptScore W2896721276C126322002 @default.
• W2896721276 hasConceptScore W2896721276C142724271 @default.
• W2896721276 hasConceptScore W2896721276C143998085 @default.
• W2896721276 hasConceptScore W2896721276C181199279 @default.
• W2896721276 hasConceptScore W2896721276C190283241 @default.
• W2896721276 hasConceptScore W2896721276C204232928 @default.
• W2896721276 hasConceptScore W2896721276C207886595 @default.
• W2896721276 hasConceptScore W2896721276C2777546739 @default.
• W2896721276 hasConceptScore W2896721276C2779689624 @default.
• W2896721276 hasConceptScore W2896721276C2994415158 @default.
• W2896721276 hasConceptScore W2896721276C44249647 @default.
• W2896721276 hasConceptScore W2896721276C50382708 @default.
• W2896721276 hasConceptScore W2896721276C55493867 @default.
• W2896721276 hasConceptScore W2896721276C67761136 @default.
• W2896721276 hasConceptScore W2896721276C71924100 @default.
• W2896721276 hasConceptScore W2896721276C86803240 @default.
• W2896721276 hasConceptScore W2896721276C90924648 @default.
• W2896721276 hasFunder F4320326275 @default.

• next