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• W2896721670 abstract "Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating FcR-based phagocytosis with complete dependence on Src family kinases, Syk, and phosphoinositide 3-kinases (PI3K). Here we show that in phagocytes, an atypical ITAM sequence in the ancient membrane anchor protein Moesin transduces signal without receptor activation. Plasma membrane deformation created by solid structure binding generates phosphatidylinositol 4,5-bisphosphate (PIP2) accumulation at the contact site, which binds the Moesin FERM domain and relocalizes Syk to the membrane via the ITAM motif. Phylogenic analysis traces this signaling using PI3K and Syk to 0.8 billion years ago, earlier than immune receptor signaling. The proposed general model of solid structure phagocytosis implies a preexisting lipid redistribution-based activation platform collecting intracellular signaling components for the emergence of immune receptors." @default.
• W2896721670 created "2018-10-26" @default.
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• W2896721670 date "2018-10-15" @default.
• W2896721670 modified "2023-10-10" @default.
• W2896721670 title "A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing" @default.
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• W2896721670 doi "https://doi.org/10.1038/s41467-018-06744-7" @default.
• W2896721670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189171" @default.
• W2896721670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323235" @default.
• W2896721670 hasPublicationYear "2018" @default.
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