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• W2896722329 endingPage "2956" @default.
• W2896722329 startingPage "2941" @default.
• W2896722329 abstract "Abstract We explore the impact of various polymers and their molecular weight on the stabilization of wet-milled suspensions of itraconazole (ITZ), a poorly soluble drug, and its dissolution from spray-dried suspensions. To this end, ITZ suspensions with SSL, SL, and L grades of hydroxypropyl cellulose (HPC) having molecular weights (MWs) of 40, 100, and 140 kg/mol, respectively, hydroxypropyl methyl cellulose (HPMC E3 with 10 kg/mol), polyvinylpyrrolidone (PVP K30 with 50 kg/mol), sodium dodecyl sulfate (SDS, surfactant), and HPC SL–SDS were wet media milled and spray-dried. Laser diffraction results show that 2.5% HPC SL–0.2% SDS led to the finest ITZ nanosuspension, whereas without SDS, only 4.5% HPC with SL/L grades ensured minimal aggregation. Rheological characterization reveals that aggregated suspensions exhibited pronounced pseudoplasticity, whereas stable suspensions exhibited near Newtonian behavior. Spray-drying yielded nanocomposites with 60–78% mean ITZ loading and acceptable content uniformity. Severe aggregation occurred during milling/drying when 4.5% polymers with MW ≤ 50 kg/mol were used; their nanocomposites exhibited incomplete redispersion due to slow matrix erosion and released ITZ slowly during dissolution test. Overall, high drug-loaded, surfactant-free ITZ nanocomposites that exhibited immediate release (>80% dissolved in 20 min) were prepared via spray-drying of wet-milled ITZ with 4.5% HPC SL/L." @default.
• W2896722329 created "2018-10-26" @default.
• W2896722329 creator A5011712484 @default.
• W2896722329 creator A5017037452 @default.
• W2896722329 creator A5034291699 @default.
• W2896722329 creator A5090980256 @default.
• W2896722329 date "2018-12-01" @default.
• W2896722329 modified "2023-10-02" @default.
• W2896722329 title "Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution from spray-dried nanocomposites" @default.
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• W2896722329 doi "https://doi.org/10.1016/j.apt.2018.09.039" @default.
• W2896722329 hasPublicationYear "2018" @default.
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