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• W2896725324 abstract "FACT (facilitates chromatin transcription) is a histone chaperone complex important in genomic processes including transcription, DNA replication, and DNA repair. FACT is composed of two proteins, SSRP1 and SPT16, which are highly conserved across eukaryotes. While the mechanisms for FACT in nucleosome reorganization and its relationship to DNA processes is well established, how these roles impact coordination in multicellular animal development are less well understood. Here we characterize the genes encoding FACT complex proteins in the nematode C. elegans. We show that whereas C. elegans includes one SPT16 gene (spt-16), two genes (hmg-3 and hmg-4) encode SSRP1 proteins. Depletion of FACT complex genes interferes with embryonic cell division and cell cycle timing generally, with anterior pharynx development especially sensitive to these defects. hmg-3 and hmg-4 exhibit redundancy for these maternally-provided embryonic functions, but are each uniquely required zygotically for normal germline development. This work provides a framework to study FACT gene function in developmental processes, and identifies that distinct functional requirements for gene duplicates can be manifest within a single tissue." @default.
• W2896725324 created "2018-10-26" @default.
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• W2896725324 date "2018-12-01" @default.
• W2896725324 modified "2023-10-14" @default.
• W2896725324 title "FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans" @default.
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• W2896725324 doi "https://doi.org/10.1016/j.ydbio.2018.10.002" @default.
• W2896725324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6310015" @default.
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• W2896725324 hasPublicationYear "2018" @default.
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