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- W2896725329 abstract "Abstract The high number of somatic mutations in the melanoma genome associated with cumulative ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With new treatment approaches based on targeted and immune therapies, drug resistance has appeared as a consistent problem. Redox biology, including reactive oxygen and nitrogen species (ROS and RNS), plays a central role in all aspects of melanoma pathophysiology, from initiation to progression and to metastatic cells. The involvement of melanin production and UV radiation in ROS/RNS generation has rendered the melanocytic lineage a unique system for studying redox biology. Overall, an elevated oxidative status has been associated with melanoma, thus much effort has been expended to prevent or treat melanoma using antioxidants which are expected to counteract oxidative stress. The consequence of this redox-rebalance seems to be two-fold: on the one hand, cells may behave less aggressively or even undergo apoptosis; on the other hand, cells may survive better after being disseminated into the circulating system or after drug treatment, thus resulting in metastasis promotion or further drug resistance. In this review we summarize the current understanding of redox signaling in melanoma at cellular and systemic levels and discuss the experimental and potential clinic use of antioxidants and new epigenetic redox modifiers." @default.
- W2896725329 created "2018-10-26" @default.
- W2896725329 creator A5000539473 @default.
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- W2896725329 creator A5029262061 @default.
- W2896725329 creator A5060872059 @default.
- W2896725329 creator A5081902406 @default.
- W2896725329 date "2018-10-31" @default.
- W2896725329 modified "2023-10-17" @default.
- W2896725329 title "Oxidative stress and antioxidants in the pathophysiology of malignant melanoma" @default.
- W2896725329 cites W1257476707 @default.
- W2896725329 cites W1275502776 @default.
- W2896725329 cites W1525444530 @default.
- W2896725329 cites W1549263005 @default.
- W2896725329 cites W1574994177 @default.
- W2896725329 cites W1606935795 @default.
- W2896725329 cites W1674731755 @default.
- W2896725329 cites W1864178760 @default.
- W2896725329 cites W1865971183 @default.
- W2896725329 cites W1896529685 @default.
- W2896725329 cites W1904831537 @default.
- W2896725329 cites W1964377459 @default.
- W2896725329 cites W1965259410 @default.
- W2896725329 cites W1966421109 @default.
- W2896725329 cites W1967695112 @default.
- W2896725329 cites W1968926794 @default.
- W2896725329 cites W1970258245 @default.
- W2896725329 cites W1970449040 @default.
- W2896725329 cites W1971435587 @default.
- W2896725329 cites W1972825083 @default.
- W2896725329 cites W1975504695 @default.
- W2896725329 cites W1978772332 @default.
- W2896725329 cites W1978870919 @default.
- W2896725329 cites W1980958927 @default.
- W2896725329 cites W1982037979 @default.
- W2896725329 cites W1984649300 @default.
- W2896725329 cites W1985033865 @default.
- W2896725329 cites W1986109500 @default.
- W2896725329 cites W1986919010 @default.
- W2896725329 cites W1987292751 @default.
- W2896725329 cites W1988315401 @default.
- W2896725329 cites W1990061176 @default.
- W2896725329 cites W1991073909 @default.
- W2896725329 cites W1991774293 @default.
- W2896725329 cites W1992176896 @default.
- W2896725329 cites W1992290505 @default.
- W2896725329 cites W1992298824 @default.
- W2896725329 cites W1992390260 @default.
- W2896725329 cites W1992431968 @default.
- W2896725329 cites W1992724001 @default.
- W2896725329 cites W1995064318 @default.
- W2896725329 cites W1995652955 @default.
- W2896725329 cites W1998745344 @default.
- W2896725329 cites W1999679043 @default.
- W2896725329 cites W2000112260 @default.
- W2896725329 cites W2000446154 @default.
- W2896725329 cites W2002090206 @default.
- W2896725329 cites W2007686006 @default.
- W2896725329 cites W2008735496 @default.
- W2896725329 cites W2009669913 @default.
- W2896725329 cites W2009897564 @default.
- W2896725329 cites W2010705646 @default.
- W2896725329 cites W2010756713 @default.
- W2896725329 cites W2016105349 @default.
- W2896725329 cites W2017605218 @default.
- W2896725329 cites W2017926666 @default.
- W2896725329 cites W2018037495 @default.
- W2896725329 cites W2020068152 @default.
- W2896725329 cites W2022212425 @default.
- W2896725329 cites W2023259543 @default.
- W2896725329 cites W2024811210 @default.
- W2896725329 cites W2028996951 @default.
- W2896725329 cites W2029491963 @default.
- W2896725329 cites W2031203591 @default.
- W2896725329 cites W2032336626 @default.
- W2896725329 cites W2033007699 @default.
- W2896725329 cites W2033708806 @default.
- W2896725329 cites W2034031966 @default.
- W2896725329 cites W2034721170 @default.
- W2896725329 cites W2034822895 @default.
- W2896725329 cites W2035000040 @default.
- W2896725329 cites W2037855793 @default.
- W2896725329 cites W2038176181 @default.
- W2896725329 cites W2038246259 @default.
- W2896725329 cites W2038561084 @default.
- W2896725329 cites W2038652783 @default.
- W2896725329 cites W2042458891 @default.
- W2896725329 cites W2043666859 @default.
- W2896725329 cites W2045085249 @default.
- W2896725329 cites W2049169526 @default.
- W2896725329 cites W2050240439 @default.
- W2896725329 cites W2052154747 @default.
- W2896725329 cites W2055637504 @default.
- W2896725329 cites W2056347167 @default.
- W2896725329 cites W2056538157 @default.
- W2896725329 cites W2058414013 @default.
- W2896725329 cites W2058461613 @default.