Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896728499> ?p ?o ?g. }
- W2896728499 abstract "Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficient to break self-tolerance, highlights their crucial role in the physiological modulation of immune responses. Here, we discuss the rationale for targeting immune checkpoint receptors with agonistic agents in autoimmunity, to restore tolerance when it is lost. We review progress that has been made to date, using Fc-fusion proteins, monoclonal antibodies or other novel constructs to induce immunosuppressive signaling through these pathways. Finally, we explore potential mechanisms by which these receptors trigger and modulate immune cell function, and how understanding these processes might shape the design of more effective therapeutic agents in future." @default.
- W2896728499 created "2018-10-26" @default.
- W2896728499 creator A5062772657 @default.
- W2896728499 creator A5064309344 @default.
- W2896728499 creator A5075122404 @default.
- W2896728499 creator A5081447773 @default.
- W2896728499 creator A5089039225 @default.
- W2896728499 date "2018-10-08" @default.
- W2896728499 modified "2023-10-17" @default.
- W2896728499 title "Immune Checkpoints as Therapeutic Targets in Autoimmunity" @default.
- W2896728499 cites W1185432402 @default.
- W2896728499 cites W1272279277 @default.
- W2896728499 cites W1523439911 @default.
- W2896728499 cites W1524072031 @default.
- W2896728499 cites W1533250563 @default.
- W2896728499 cites W1572739876 @default.
- W2896728499 cites W1588726805 @default.
- W2896728499 cites W1612601009 @default.
- W2896728499 cites W1613752608 @default.
- W2896728499 cites W1616993747 @default.
- W2896728499 cites W1817487237 @default.
- W2896728499 cites W1885606726 @default.
- W2896728499 cites W1905186867 @default.
- W2896728499 cites W1952564517 @default.
- W2896728499 cites W1972073222 @default.
- W2896728499 cites W1975934877 @default.
- W2896728499 cites W1984622299 @default.
- W2896728499 cites W1985543678 @default.
- W2896728499 cites W1985997449 @default.
- W2896728499 cites W1986805605 @default.
- W2896728499 cites W1988331425 @default.
- W2896728499 cites W1988567102 @default.
- W2896728499 cites W1990791112 @default.
- W2896728499 cites W1993967286 @default.
- W2896728499 cites W1997988662 @default.
- W2896728499 cites W1999623709 @default.
- W2896728499 cites W2002717318 @default.
- W2896728499 cites W2014541497 @default.
- W2896728499 cites W2017873446 @default.
- W2896728499 cites W2031978254 @default.
- W2896728499 cites W2032466777 @default.
- W2896728499 cites W2035759292 @default.
- W2896728499 cites W2037307180 @default.
- W2896728499 cites W2056535502 @default.
- W2896728499 cites W2057648030 @default.
- W2896728499 cites W2068470913 @default.
- W2896728499 cites W2070631889 @default.
- W2896728499 cites W2071561368 @default.
- W2896728499 cites W2072448714 @default.
- W2896728499 cites W2072770765 @default.
- W2896728499 cites W2073776582 @default.
- W2896728499 cites W2076067786 @default.
- W2896728499 cites W2076601151 @default.
- W2896728499 cites W2081255498 @default.
- W2896728499 cites W2083189057 @default.
- W2896728499 cites W2083340623 @default.
- W2896728499 cites W2084248982 @default.
- W2896728499 cites W2088230855 @default.
- W2896728499 cites W2091609575 @default.
- W2896728499 cites W2097527928 @default.
- W2896728499 cites W2097995306 @default.
- W2896728499 cites W2098853737 @default.
- W2896728499 cites W2099854994 @default.
- W2896728499 cites W2100499915 @default.
- W2896728499 cites W2103100938 @default.
- W2896728499 cites W2104689783 @default.
- W2896728499 cites W2107322032 @default.
- W2896728499 cites W2111811086 @default.
- W2896728499 cites W2116469578 @default.
- W2896728499 cites W2117443086 @default.
- W2896728499 cites W2117973220 @default.
- W2896728499 cites W2122700509 @default.
- W2896728499 cites W2123129311 @default.
- W2896728499 cites W2124259702 @default.
- W2896728499 cites W2128035403 @default.
- W2896728499 cites W2128063282 @default.
- W2896728499 cites W2131387566 @default.
- W2896728499 cites W2141989396 @default.
- W2896728499 cites W2143163879 @default.
- W2896728499 cites W2152605128 @default.
- W2896728499 cites W2161693332 @default.
- W2896728499 cites W2162957239 @default.
- W2896728499 cites W2164673574 @default.
- W2896728499 cites W2164815203 @default.
- W2896728499 cites W2167238978 @default.
- W2896728499 cites W2172160382 @default.
- W2896728499 cites W2203541757 @default.
- W2896728499 cites W2265285917 @default.
- W2896728499 cites W2323330456 @default.
- W2896728499 cites W2398619572 @default.
- W2896728499 cites W2411733041 @default.
- W2896728499 cites W2592173429 @default.
- W2896728499 cites W2599988723 @default.
- W2896728499 cites W2754774331 @default.
- W2896728499 cites W2766378499 @default.
- W2896728499 cites W2790795290 @default.
- W2896728499 cites W2793629403 @default.
- W2896728499 cites W2794577178 @default.
- W2896728499 cites W4251074092 @default.
- W2896728499 doi "https://doi.org/10.3389/fimmu.2018.02306" @default.