FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896729655> ?p ?o ?g. }

• W2896729655 endingPage "e0204731" @default.
• W2896729655 startingPage "e0204731" @default.
• W2896729655 abstract "This study explores the effects of maternal separation as a chronic early life stress (ELS) on pancreatic islets insulin content and secretion, and their potential relationship with the hippocampus insulin content and spatial memory in young adulthood. Male rat offspring were divided into two groups: stress (STR) and non-stress (non-STR) groups. The animals of the STR group were separated from their mothers during postnatal days (PND) 1 to 21. During the weaning time, that is, PND-0 to PND-21, the body weight and length of the pups were measured. Blood samples were collected on PND-1, 21, 29 and 34 and during young adulthood (53±2 days) to determine plasma corticosterone and insulin levels. The young adult animals were also tested for spatial memory. One day after the memory test, the animals were decapitated and their pancreases were removed to measure the islets insulin content and secretion. Finally, the animals' hippocampi were isolated to determine their insulin content and insulin receptor protein amounts. During the period of weaning, the body weight and length of pups belonging to the STR group were significantly lower as compared to those in the non-STR group. Maternal separation did not change the plasma levels of insulin but increased plasma corticosterone levels from PND-21 to young adulthood and also reduced the islets insulin content but did not affect insulin secretion and the hippocampus insulin content and insulin receptor protein amount. Although, at the end of the memory tests, rats of the STR group reached the escape box at almost the same time and distance and with the same errors as rats of the non-STR group, the distance traveled to reach the escape box showed a steep reduction in the non-STR group as compared to the STR group after the first trial. Moreover, as compared to the STR group, the non-STR group showed an increasing trend for direct strategy to find the escape box. The islets insulin content and secretion, and the plasma insulin concentration were not significantly correlated with the hippocampus insulin content. From the results of the present study, it appears that the main behavioral effect of the maternal separation stress in the spatial memory task was to impair the strategy used by the animals to reach the escape box. This may indicate that maternal separation stress affects brain regions other than the hippocampus. Moreover, due to the reduction of the body weight and length of offspring belonging to the STR group, it should be further considered that both maternal separation and early life malnutrition are directly (and mechanistically) linked to cognitive alterations later in life in ways that are not dependent on peripheral and hippocampal insulin content." @default.
• W2896729655 created "2018-10-26" @default.
• W2896729655 creator A5004391089 @default.
• W2896729655 creator A5007813023 @default.
• W2896729655 creator A5022276742 @default.
• W2896729655 creator A5028601646 @default.
• W2896729655 creator A5030045562 @default.
• W2896729655 creator A5057534597 @default.
• W2896729655 creator A5064461615 @default.
• W2896729655 creator A5084902873 @default.
• W2896729655 date "2018-10-17" @default.
• W2896729655 modified "2023-10-17" @default.
• W2896729655 title "Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats" @default.
• W2896729655 cites W1160756260 @default.
• W2896729655 cites W1536927042 @default.
• W2896729655 cites W1795784935 @default.
• W2896729655 cites W1961392298 @default.
• W2896729655 cites W1962474939 @default.
• W2896729655 cites W1965352353 @default.
• W2896729655 cites W1966989255 @default.
• W2896729655 cites W1970620887 @default.
• W2896729655 cites W1977666924 @default.
• W2896729655 cites W1978808714 @default.
• W2896729655 cites W1985645068 @default.
• W2896729655 cites W1989459989 @default.
• W2896729655 cites W1992115200 @default.
• W2896729655 cites W1996642120 @default.
• W2896729655 cites W1999333694 @default.
• W2896729655 cites W2000157976 @default.
• W2896729655 cites W2002456558 @default.
• W2896729655 cites W2002684432 @default.
• W2896729655 cites W2014508157 @default.
• W2896729655 cites W2014570372 @default.
• W2896729655 cites W2019341789 @default.
• W2896729655 cites W2020647745 @default.
• W2896729655 cites W2024394464 @default.
• W2896729655 cites W2025997841 @default.
• W2896729655 cites W2030260775 @default.
• W2896729655 cites W2049871798 @default.
• W2896729655 cites W2053436208 @default.
• W2896729655 cites W2057726371 @default.
• W2896729655 cites W2058537633 @default.
• W2896729655 cites W2060414598 @default.
• W2896729655 cites W2065252592 @default.
• W2896729655 cites W2071725094 @default.
• W2896729655 cites W2080450177 @default.
• W2896729655 cites W2080496806 @default.
• W2896729655 cites W2080520511 @default.
• W2896729655 cites W2080893160 @default.
• W2896729655 cites W2089417411 @default.
• W2896729655 cites W2091900102 @default.
• W2896729655 cites W2103861118 @default.
• W2896729655 cites W2110419377 @default.
• W2896729655 cites W2112354679 @default.
• W2896729655 cites W2113547116 @default.
• W2896729655 cites W2114301383 @default.
• W2896729655 cites W2115316535 @default.
• W2896729655 cites W2116721266 @default.
• W2896729655 cites W2121411996 @default.
• W2896729655 cites W2123541107 @default.
• W2896729655 cites W2126531992 @default.
• W2896729655 cites W2135562556 @default.
• W2896729655 cites W2135591161 @default.
• W2896729655 cites W2137247960 @default.
• W2896729655 cites W2146132701 @default.
• W2896729655 cites W2146429498 @default.
• W2896729655 cites W2146840535 @default.
• W2896729655 cites W2148335305 @default.
• W2896729655 cites W2149617947 @default.
• W2896729655 cites W2153284686 @default.
• W2896729655 cites W2155873686 @default.
• W2896729655 cites W2157865424 @default.
• W2896729655 cites W2162513641 @default.
• W2896729655 cites W2181158667 @default.
• W2896729655 cites W2184948420 @default.
• W2896729655 cites W2230920242 @default.
• W2896729655 cites W2235429109 @default.
• W2896729655 cites W2290330016 @default.
• W2896729655 cites W2336520263 @default.
• W2896729655 cites W2497601590 @default.
• W2896729655 cites W2511528658 @default.
• W2896729655 cites W2522988932 @default.
• W2896729655 cites W2585679638 @default.
• W2896729655 cites W2593138628 @default.
• W2896729655 cites W2795292238 @default.
• W2896729655 cites W4230783006 @default.
• W2896729655 cites W756325778 @default.
• W2896729655 doi "https://doi.org/10.1371/journal.pone.0204731" @default.
• W2896729655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6328197" @default.
• W2896729655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30629701" @default.
• W2896729655 hasPublicationYear "2018" @default.
• W2896729655 type Work @default.
• W2896729655 sameAs 2896729655 @default.
• W2896729655 citedByCount "31" @default.
• W2896729655 countsByYear W28967296552019 @default.
• W2896729655 countsByYear W28967296552020 @default.
• W2896729655 countsByYear W28967296552021 @default.
• W2896729655 countsByYear W28967296552022 @default.

• next