FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896732467> ?p ?o ?g. }

• W2896732467 endingPage "105" @default.
• W2896732467 startingPage "94" @default.
• W2896732467 abstract "Toll-like receptors (TLRs) and C-type lectin receptors (CLRs) contribute to antigen capture, uptake, presentation and activation of immune responses. We recently developed a new and lymph node (LN) targeting adjuvant (D-CpG) by chemical conjugation type B CpG DNA with FDA-approved dextran polymer for lymph node imaging. To elucidate the possible antitumor mechanisms of this adjuvant, prophylaxis and therapeutic models of melanoma were used in this study. Our results showed that D-CpG was an efficient adjuvant of protein-based tumor vaccine in both prophylaxis and therapeutic models. It enhanced the tumor-specific Th1 and CTL responses. It also facilitated the tumor infiltration of the T cells and promoted IFNγ and TNFα production of both CD4+ and CD8+ T cells. In therapeutic model, D-CpG included tumor vaccine decreased the percentage of CD11b+Gr1low+ MDSCs in spleen and inhibited their infiltration in tumor microenvironments. Administration of the D-CpG included vaccine significantly inhibited lung metastasis of the tumor through similar mechanisms. In conclusion, D-CpG used as tumor vaccine adjuvant can enhance both Th1 and CTL responses and inhibit CD11b+Gr1low MDSCs, which may have general applicability to the development of vaccines against tumors." @default.
• W2896732467 created "2018-10-26" @default.
• W2896732467 creator A5029507056 @default.
• W2896732467 creator A5042228463 @default.
• W2896732467 creator A5058887646 @default.
• W2896732467 creator A5059883833 @default.
• W2896732467 creator A5077060343 @default.
• W2896732467 creator A5089730660 @default.
• W2896732467 creator A5090864607 @default.
• W2896732467 date "2019-01-01" @default.
• W2896732467 modified "2023-10-15" @default.
• W2896732467 title "Carbohydrate-based adjuvants activate tumor-specific Th1 and CD8+ T-cell responses and reduce the immunosuppressive activity of MDSCs" @default.
• W2896732467 cites W1600026204 @default.
• W2896732467 cites W1967792496 @default.
• W2896732467 cites W1969372348 @default.
• W2896732467 cites W1986222655 @default.
• W2896732467 cites W2002720281 @default.
• W2896732467 cites W2003594862 @default.
• W2896732467 cites W2012654541 @default.
• W2896732467 cites W2021369287 @default.
• W2896732467 cites W2032277307 @default.
• W2896732467 cites W2058219351 @default.
• W2896732467 cites W2062956416 @default.
• W2896732467 cites W2121044753 @default.
• W2896732467 cites W2151998105 @default.
• W2896732467 cites W2156491299 @default.
• W2896732467 cites W2163941384 @default.
• W2896732467 cites W2288921756 @default.
• W2896732467 cites W2340769165 @default.
• W2896732467 cites W2347085129 @default.
• W2896732467 cites W2541860579 @default.
• W2896732467 cites W2544468429 @default.
• W2896732467 cites W2559918261 @default.
• W2896732467 cites W2582365165 @default.
• W2896732467 cites W2611361945 @default.
• W2896732467 cites W2611380550 @default.
• W2896732467 cites W2648573262 @default.
• W2896732467 cites W2665491521 @default.
• W2896732467 cites W2765367127 @default.
• W2896732467 cites W2774708827 @default.
• W2896732467 cites W2790541566 @default.
• W2896732467 cites W2794117012 @default.
• W2896732467 cites W2795293588 @default.
• W2896732467 cites W2795535550 @default.
• W2896732467 cites W2800305798 @default.
• W2896732467 cites W2800712256 @default.
• W2896732467 cites W2803421668 @default.
• W2896732467 cites W425698388 @default.
• W2896732467 cites W570360169 @default.
• W2896732467 doi "https://doi.org/10.1016/j.canlet.2018.10.013" @default.
• W2896732467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30352261" @default.
• W2896732467 hasPublicationYear "2019" @default.
• W2896732467 type Work @default.
• W2896732467 sameAs 2896732467 @default.
• W2896732467 citedByCount "13" @default.
• W2896732467 countsByYear W28967324672019 @default.
• W2896732467 countsByYear W28967324672020 @default.
• W2896732467 countsByYear W28967324672021 @default.
• W2896732467 countsByYear W28967324672022 @default.
• W2896732467 countsByYear W28967324672023 @default.
• W2896732467 crossrefType "journal-article" @default.
• W2896732467 hasAuthorship W2896732467A5029507056 @default.
• W2896732467 hasAuthorship W2896732467A5042228463 @default.
• W2896732467 hasAuthorship W2896732467A5058887646 @default.
• W2896732467 hasAuthorship W2896732467A5059883833 @default.
• W2896732467 hasAuthorship W2896732467A5077060343 @default.
• W2896732467 hasAuthorship W2896732467A5089730660 @default.
• W2896732467 hasAuthorship W2896732467A5090864607 @default.
• W2896732467 hasConcept C104317684 @default.
• W2896732467 hasConcept C147483822 @default.
• W2896732467 hasConcept C147969180 @default.
• W2896732467 hasConcept C150194340 @default.
• W2896732467 hasConcept C167672396 @default.
• W2896732467 hasConcept C190727270 @default.
• W2896732467 hasConcept C203014093 @default.
• W2896732467 hasConcept C22801619 @default.
• W2896732467 hasConcept C2776090121 @default.
• W2896732467 hasConcept C2777701055 @default.
• W2896732467 hasConcept C2777863537 @default.
• W2896732467 hasConcept C2778378633 @default.
• W2896732467 hasConcept C502942594 @default.
• W2896732467 hasConcept C55493867 @default.
• W2896732467 hasConcept C71924100 @default.
• W2896732467 hasConcept C86803240 @default.
• W2896732467 hasConcept C8891405 @default.
• W2896732467 hasConceptScore W2896732467C104317684 @default.
• W2896732467 hasConceptScore W2896732467C147483822 @default.
• W2896732467 hasConceptScore W2896732467C147969180 @default.
• W2896732467 hasConceptScore W2896732467C150194340 @default.
• W2896732467 hasConceptScore W2896732467C167672396 @default.
• W2896732467 hasConceptScore W2896732467C190727270 @default.
• W2896732467 hasConceptScore W2896732467C203014093 @default.
• W2896732467 hasConceptScore W2896732467C22801619 @default.
• W2896732467 hasConceptScore W2896732467C2776090121 @default.
• W2896732467 hasConceptScore W2896732467C2777701055 @default.
• W2896732467 hasConceptScore W2896732467C2777863537 @default.
• W2896732467 hasConceptScore W2896732467C2778378633 @default.
• W2896732467 hasConceptScore W2896732467C502942594 @default.

• next