Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896733360> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2896733360 endingPage "e164" @default.
- W2896733360 startingPage "e164" @default.
- W2896733360 abstract "To investigate the effects of low-dose irradiation on the phagocytosis and phenotypic conversion of tumor-associated macrophages (TAMs) via the dynamic assessment of the expression of SIRPa. Experiments were performed with healthy male C57BL / 5J mice with subcutaneous inoculation of GFP-luc+ Lewis lung cancer cells in the back. The experimental group received treatment of 2Gy irradiation to the xenografted tumors on the 10th, 16th and 22nd days after the inoculation. The tumor response by volume measurement, the expression of SIRPa, phenotypes and phagocytic capacity of TAMs and spleen macrophages were evaluated or assayed using fluorescence-activated cell sorting (FACS) analysis on the 3rd, 6th and 9th day after irradiation. In comparison with the control group without irradiation, the radiation treatment significantly delayed the tumor growth. Radiotherapy significantly inhibited the expression of SIRPa on the surface of TAMs as well as splenic macrophages, while increasing amount of MHC II and enhanced phagocytic capability of TAMs on tumors cells were observed. The initial size of tumors (the interval between the treatment and inoculation) had impacts on the tumor growth delay amplitude, the expression of SIRPa and phagocytosis as a response to the irradiation. Better tumor control (volume reduction), lower SIRPa expression and improved phagocytosis were related to smaller treated tumors. Low-dose irradiation has the potential to promote the phenotype conversion of TAMs from pro-tumor M2 to anti-tumor M1 and restore the phagocytosis, which may be subject to tumor size." @default.
- W2896733360 created "2018-10-26" @default.
- W2896733360 creator A5042234988 @default.
- W2896733360 creator A5056289187 @default.
- W2896733360 creator A5074328280 @default.
- W2896733360 creator A5086729630 @default.
- W2896733360 date "2018-11-01" @default.
- W2896733360 modified "2023-10-18" @default.
- W2896733360 title "The Temporal Effect of Low-Dose Irradiation on the Expression of SIRPa in Tumor-Associated Macrophages" @default.
- W2896733360 doi "https://doi.org/10.1016/j.ijrobp.2018.07.627" @default.
- W2896733360 hasPublicationYear "2018" @default.
- W2896733360 type Work @default.
- W2896733360 sameAs 2896733360 @default.
- W2896733360 citedByCount "0" @default.
- W2896733360 crossrefType "journal-article" @default.
- W2896733360 hasAuthorship W2896733360A5042234988 @default.
- W2896733360 hasAuthorship W2896733360A5056289187 @default.
- W2896733360 hasAuthorship W2896733360A5074328280 @default.
- W2896733360 hasAuthorship W2896733360A5086729630 @default.
- W2896733360 hasBestOaLocation W28967333601 @default.
- W2896733360 hasConcept C104317684 @default.
- W2896733360 hasConcept C126322002 @default.
- W2896733360 hasConcept C127561419 @default.
- W2896733360 hasConcept C127716648 @default.
- W2896733360 hasConcept C160448771 @default.
- W2896733360 hasConcept C185592680 @default.
- W2896733360 hasConcept C203014093 @default.
- W2896733360 hasConcept C2780931953 @default.
- W2896733360 hasConcept C502942594 @default.
- W2896733360 hasConcept C509974204 @default.
- W2896733360 hasConcept C55493867 @default.
- W2896733360 hasConcept C71924100 @default.
- W2896733360 hasConcept C8891405 @default.
- W2896733360 hasConceptScore W2896733360C104317684 @default.
- W2896733360 hasConceptScore W2896733360C126322002 @default.
- W2896733360 hasConceptScore W2896733360C127561419 @default.
- W2896733360 hasConceptScore W2896733360C127716648 @default.
- W2896733360 hasConceptScore W2896733360C160448771 @default.
- W2896733360 hasConceptScore W2896733360C185592680 @default.
- W2896733360 hasConceptScore W2896733360C203014093 @default.
- W2896733360 hasConceptScore W2896733360C2780931953 @default.
- W2896733360 hasConceptScore W2896733360C502942594 @default.
- W2896733360 hasConceptScore W2896733360C509974204 @default.
- W2896733360 hasConceptScore W2896733360C55493867 @default.
- W2896733360 hasConceptScore W2896733360C71924100 @default.
- W2896733360 hasConceptScore W2896733360C8891405 @default.
- W2896733360 hasIssue "3" @default.
- W2896733360 hasLocation W28967333601 @default.
- W2896733360 hasOpenAccess W2896733360 @default.
- W2896733360 hasPrimaryLocation W28967333601 @default.
- W2896733360 hasRelatedWork W2036107469 @default.
- W2896733360 hasRelatedWork W2081358646 @default.
- W2896733360 hasRelatedWork W2153797564 @default.
- W2896733360 hasRelatedWork W2352332055 @default.
- W2896733360 hasRelatedWork W2355913927 @default.
- W2896733360 hasRelatedWork W2370773621 @default.
- W2896733360 hasRelatedWork W2371719575 @default.
- W2896733360 hasRelatedWork W2382386914 @default.
- W2896733360 hasRelatedWork W2384806929 @default.
- W2896733360 hasRelatedWork W2781693618 @default.
- W2896733360 hasVolume "102" @default.
- W2896733360 isParatext "false" @default.
- W2896733360 isRetracted "false" @default.
- W2896733360 magId "2896733360" @default.
- W2896733360 workType "article" @default.