Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896735777> ?p ?o ?g. }
- W2896735777 abstract "The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1.5. This channel predominates inward sodium current (INa) and plays a critical role in regulation of cardiac electrophysiological function. Since 1995, SCN5A variants have been found to be causatively associated with Brugada syndrome, long QT syndrome, cardiac conduction system dysfunction, dilated cardiomyopathy, etc. Previous genetic, electrophysiological and molecular studies have identified the arrhythmic and cardiac structural characteristics induced by SCN5A variants. However, due to the variation of disease manifestations and genetic background, impact of environmental factors, as well as the presence of mixed phenotypes, the detailed and individualized physiological mechanisms in various SCN5A-related syndromes are not fully elucidated. This review summarizes the current knowledge of SCN5A genetic variations in different SCN5A-related cardiac disorders and the newly developed therapy strategies potentially useful to prevent and treat these disorders in the clinical setting." @default.
- W2896735777 created "2018-10-26" @default.
- W2896735777 creator A5001624794 @default.
- W2896735777 creator A5030160540 @default.
- W2896735777 creator A5047906426 @default.
- W2896735777 creator A5076823638 @default.
- W2896735777 creator A5078164215 @default.
- W2896735777 creator A5084012869 @default.
- W2896735777 date "2018-10-09" @default.
- W2896735777 modified "2023-10-18" @default.
- W2896735777 title "SCN5A Variants: Association With Cardiac Disorders" @default.
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