FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896738115> ?p ?o ?g. }

• W2896738115 endingPage "51" @default.
• W2896738115 startingPage "48" @default.
• W2896738115 abstract "Since pro-inflammatory cytokine IL-18 and its receptor (IL-18R) are closely involved in regulating both adaptive and innate immune responses, it is conceivable that they might play an important role in organ transplantation. IL-18 can stimulate lymphocytes to produce the IFN-γ and regulate macrophage activity, thereby increasing the expression of proinflammatory cytokines including IL-1β, IL-6, CCL4 (macrophage inflammatory protein-1 β), CXCL2 (macrophage inflammatory protein-2), and CCL2 (monocyte chemotactic protein-1). Nevertheless, the IL-18 signaling pathway and its underlying mechanisms remain obscure in transplant biology. This review is to summarize recent advances in our knowledge about the IL-18 signaling pathway and to analyze their functions in transplant-related biology. It was found that IL-18/IL-18R signaling pathway contributed to vascular transplantation, ischemmia/reperfusion, acute kidney injury, and acute rejection of kidney/liver/heart transplantation. IL-18 was a potential CYP3A expression modulator and was capable of affecting tacrolimus pharmacokinetics. Neutralizing IL-18 by its inhibitor IL-18 binding protein could efficiently suppress the production of injury-associated cytokines such as IL-6, TNF-α, IFN-γ, CXCL10 (IFN-γ-inducible protein10), and CX3CL1 (fractalkine) and improve allograft function. Blockade of IL-18 signaling could regulate cardiomyocyte apoptosis and inhibit Th17 cells differentiation. Alteration of IL-18 levels was suggested as a biomarker for predicting ongoing allograft outcome. All these activities could deepen our understanding of immunobiological role of IL-18 and its receptor in the field of organ transplantation. Intervention of IL-18 signaling pathway might be utilized as a therapeutic strategy in clinic." @default.
• W2896738115 created "2018-10-26" @default.
• W2896738115 creator A5000424434 @default.
• W2896738115 creator A5003360183 @default.
• W2896738115 creator A5006114877 @default.
• W2896738115 creator A5032681931 @default.
• W2896738115 creator A5060624483 @default.
• W2896738115 creator A5075369405 @default.
• W2896738115 creator A5082646269 @default.
• W2896738115 creator A5088804993 @default.
• W2896738115 date "2018-06-01" @default.
• W2896738115 modified "2023-10-11" @default.
• W2896738115 title "Role of IL-18 in transplant biology" @default.
• W2896738115 cites W1859836106 @default.
• W2896738115 cites W1872869368 @default.
• W2896738115 cites W1979063381 @default.
• W2896738115 cites W2014018206 @default.
• W2896738115 cites W2018285857 @default.
• W2896738115 cites W2019916033 @default.
• W2896738115 cites W2031896407 @default.
• W2896738115 cites W2033597315 @default.
• W2896738115 cites W2036635132 @default.
• W2896738115 cites W2037584068 @default.
• W2896738115 cites W2041517879 @default.
• W2896738115 cites W2088754465 @default.
• W2896738115 cites W2092832667 @default.
• W2896738115 cites W2103509117 @default.
• W2896738115 cites W2131534540 @default.
• W2896738115 cites W2134365281 @default.
• W2896738115 cites W2153279598 @default.
• W2896738115 cites W2159886553 @default.
• W2896738115 cites W2166037275 @default.
• W2896738115 cites W2170433159 @default.
• W2896738115 cites W2170716437 @default.
• W2896738115 cites W2171849343 @default.
• W2896738115 cites W2742318684 @default.
• W2896738115 cites W2781447571 @default.
• W2896738115 cites W2803035762 @default.
• W2896738115 cites W2344414825 @default.
• W2896738115 doi "https://doi.org/10.1684/ecn.2018.0410" @default.
• W2896738115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30078783" @default.
• W2896738115 hasPublicationYear "2018" @default.
• W2896738115 type Work @default.
• W2896738115 sameAs 2896738115 @default.
• W2896738115 citedByCount "21" @default.
• W2896738115 countsByYear W28967381152019 @default.
• W2896738115 countsByYear W28967381152020 @default.
• W2896738115 countsByYear W28967381152021 @default.
• W2896738115 countsByYear W28967381152022 @default.
• W2896738115 countsByYear W28967381152023 @default.
• W2896738115 crossrefType "journal-article" @default.
• W2896738115 hasAuthorship W2896738115A5000424434 @default.
• W2896738115 hasAuthorship W2896738115A5003360183 @default.
• W2896738115 hasAuthorship W2896738115A5006114877 @default.
• W2896738115 hasAuthorship W2896738115A5032681931 @default.
• W2896738115 hasAuthorship W2896738115A5060624483 @default.
• W2896738115 hasAuthorship W2896738115A5075369405 @default.
• W2896738115 hasAuthorship W2896738115A5082646269 @default.
• W2896738115 hasAuthorship W2896738115A5088804993 @default.
• W2896738115 hasBestOaLocation W28967381151 @default.
• W2896738115 hasConcept C126322002 @default.
• W2896738115 hasConcept C12823836 @default.
• W2896738115 hasConcept C13373296 @default.
• W2896738115 hasConcept C164027704 @default.
• W2896738115 hasConcept C168444539 @default.
• W2896738115 hasConcept C179661763 @default.
• W2896738115 hasConcept C203014093 @default.
• W2896738115 hasConcept C2776914184 @default.
• W2896738115 hasConcept C2778690821 @default.
• W2896738115 hasConcept C2780179540 @default.
• W2896738115 hasConcept C2911091166 @default.
• W2896738115 hasConcept C502942594 @default.
• W2896738115 hasConcept C5858377 @default.
• W2896738115 hasConcept C62478195 @default.
• W2896738115 hasConcept C71924100 @default.
• W2896738115 hasConcept C86803240 @default.
• W2896738115 hasConcept C8891405 @default.
• W2896738115 hasConcept C95444343 @default.
• W2896738115 hasConceptScore W2896738115C126322002 @default.
• W2896738115 hasConceptScore W2896738115C12823836 @default.
• W2896738115 hasConceptScore W2896738115C13373296 @default.
• W2896738115 hasConceptScore W2896738115C164027704 @default.
• W2896738115 hasConceptScore W2896738115C168444539 @default.
• W2896738115 hasConceptScore W2896738115C179661763 @default.
• W2896738115 hasConceptScore W2896738115C203014093 @default.
• W2896738115 hasConceptScore W2896738115C2776914184 @default.
• W2896738115 hasConceptScore W2896738115C2778690821 @default.
• W2896738115 hasConceptScore W2896738115C2780179540 @default.
• W2896738115 hasConceptScore W2896738115C2911091166 @default.
• W2896738115 hasConceptScore W2896738115C502942594 @default.
• W2896738115 hasConceptScore W2896738115C5858377 @default.
• W2896738115 hasConceptScore W2896738115C62478195 @default.
• W2896738115 hasConceptScore W2896738115C71924100 @default.
• W2896738115 hasConceptScore W2896738115C86803240 @default.
• W2896738115 hasConceptScore W2896738115C8891405 @default.
• W2896738115 hasConceptScore W2896738115C95444343 @default.
• W2896738115 hasIssue "2" @default.
• W2896738115 hasLocation W28967381151 @default.

• next