Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896739908> ?p ?o ?g. }
- W2896739908 abstract "The goal of this study was to identify the baseline host and viral factors of response to antiviral therapy in patients with chronic hepatitis C. Compared with interferon/ribavirin therapy, new current direct-acting antiviral (DAA) combination regimens significantly increased rate of sustained virologic response (SVR) and shorter treatment durations, but is still limited by viral resistance, adverse effects, and high cost especially in developing countries. Human genetic factors and heterogeneity within the HCV genome may be associated with virologic treatment failure before and after antiviral therapy. Further, HCV infection may contribute to the development of HCV-related liver disease and hepatocarcinogenesis, through modulating genetic and epigenetic state of certain genes implicated in control of critical cellular pathways. Previous results confirm the importance of host and viral factors and virus-induced genetic and epigenetic changes in predicting outcome and treatment response." @default.
- W2896739908 created "2018-10-26" @default.
- W2896739908 creator A5009745380 @default.
- W2896739908 creator A5038971281 @default.
- W2896739908 creator A5054549347 @default.
- W2896739908 creator A5091259052 @default.
- W2896739908 date "2018-10-10" @default.
- W2896739908 modified "2023-09-23" @default.
- W2896739908 title "Hepatitis C: Host and Viral Factors Associated with Response to Therapy and Progression of Liver Fibrosis" @default.
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