FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896741434> ?p ?o ?g. }

• W2896741434 endingPage "35041" @default.
• W2896741434 startingPage "35031" @default.
• W2896741434 abstract "To investigate the role of FOXO1 and miR-183-96-182 clusters in ox-LDL induced endothelial cell apoptosis.FOXO1 overexpression (OE) and knockdown (KD) as well as AKT1 OE in human umbilical vein endothelial cells (HUVECs) and human aortic endothelial cells (HAECs) were achieved by lentiviral transduction. Upregulation of miR-183-5p, miR-182-5p or miR-96-5p was mimicked by agomir treatment. FOXO1 gene transcription was monitored by FOXO1 promotor reporter assay. Cell apoptosis in culture was monitored by TiterTACS in situ detection. Regulation of FOXO1 gene expression by an miRNA targeting mechanism was monitored by AGO2-RNA immunoprecipitation assay.FOXO1 mRNA and protein expression levels in ox-LDL treated HUVECs or HAECs were significantly upregulated due to transcriptional and miRNA targeting mechanisms. MiR-183-5p, miR-182-5p and miR-96-5p expression levels in HUVECs or HAECs were significantly reduced by ox-LDL treatment, the overexpression of which by agomir treatment partially reduced the FOXO1 mRNA/protein expression levels and cell apoptosis which was upregulated by ox-LDL treatment. FOXO1 overexpression antagonized the effect of the agomir treatment indicated above. MiR-183-5p, miR-182-5p and miR-96-5p agomir treatment partially rescued the FOXO1 pSer256/total FOXO1 protein ratio and the AKT1 pSer473 level that were reduced by ox-LDL treatment in the HUVECs or HAECs. AKT1 overexpression significantly reduced FOXO1 protein expression, increased miR-182-5p and miR-183-5p expression, and partially alleviated ox-LDL induced HUVEC or HAEC apoptosis in an miR-183-5p and miR-182-5p-dependent manner.miR-183-96-182 clusters could partially alleviate ox-LDL-induced apoptosis in HUVECs or HAECs by targeting FOXO1." @default.
• W2896741434 created "2018-10-26" @default.
• W2896741434 creator A5010496866 @default.
• W2896741434 creator A5021905687 @default.
• W2896741434 creator A5030611214 @default.
• W2896741434 creator A5031150824 @default.
• W2896741434 creator A5033527896 @default.
• W2896741434 creator A5041468811 @default.
• W2896741434 creator A5043392866 @default.
• W2896741434 creator A5062682434 @default.
• W2896741434 creator A5070213503 @default.
• W2896741434 creator A5086729495 @default.
• W2896741434 date "2018-01-01" @default.
• W2896741434 modified "2023-09-23" @default.
• W2896741434 title "miR-183-96-182 clusters alleviated ox-LDL-induced vascular endothelial cell apoptosis <i>in vitro</i> by targeting FOXO1" @default.
• W2896741434 cites W1503626258 @default.
• W2896741434 cites W1745497386 @default.
• W2896741434 cites W1916543860 @default.
• W2896741434 cites W2004475371 @default.
• W2896741434 cites W2005772573 @default.
• W2896741434 cites W2023073560 @default.
• W2896741434 cites W2025531808 @default.
• W2896741434 cites W2057690836 @default.
• W2896741434 cites W2072009397 @default.
• W2896741434 cites W2098550211 @default.
• W2896741434 cites W2107782164 @default.
• W2896741434 cites W2113539023 @default.
• W2896741434 cites W2121476686 @default.
• W2896741434 cites W2122724788 @default.
• W2896741434 cites W2155160938 @default.
• W2896741434 cites W2161145604 @default.
• W2896741434 cites W2163245419 @default.
• W2896741434 cites W2168774749 @default.
• W2896741434 cites W2169046108 @default.
• W2896741434 cites W2251225786 @default.
• W2896741434 cites W2275204317 @default.
• W2896741434 cites W2286053987 @default.
• W2896741434 cites W2312392809 @default.
• W2896741434 cites W2418947410 @default.
• W2896741434 cites W2582447287 @default.
• W2896741434 cites W2587769401 @default.
• W2896741434 cites W2591729572 @default.
• W2896741434 cites W2593661054 @default.
• W2896741434 cites W2599007055 @default.
• W2896741434 cites W2620254432 @default.
• W2896741434 cites W2740228938 @default.
• W2896741434 cites W2740755021 @default.
• W2896741434 cites W2753408816 @default.
• W2896741434 cites W2767688174 @default.
• W2896741434 cites W2774009898 @default.
• W2896741434 cites W2783125229 @default.
• W2896741434 cites W320106238 @default.
• W2896741434 cites W863552944 @default.
• W2896741434 doi "https://doi.org/10.1039/c8ra06866f" @default.
• W2896741434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35547044" @default.
• W2896741434 hasPublicationYear "2018" @default.
• W2896741434 type Work @default.
• W2896741434 sameAs 2896741434 @default.
• W2896741434 citedByCount "5" @default.
• W2896741434 countsByYear W28967414342019 @default.
• W2896741434 countsByYear W28967414342020 @default.
• W2896741434 countsByYear W28967414342021 @default.
• W2896741434 countsByYear W28967414342022 @default.
• W2896741434 crossrefType "journal-article" @default.
• W2896741434 hasAuthorship W2896741434A5010496866 @default.
• W2896741434 hasAuthorship W2896741434A5021905687 @default.
• W2896741434 hasAuthorship W2896741434A5030611214 @default.
• W2896741434 hasAuthorship W2896741434A5031150824 @default.
• W2896741434 hasAuthorship W2896741434A5033527896 @default.
• W2896741434 hasAuthorship W2896741434A5041468811 @default.
• W2896741434 hasAuthorship W2896741434A5043392866 @default.
• W2896741434 hasAuthorship W2896741434A5062682434 @default.
• W2896741434 hasAuthorship W2896741434A5070213503 @default.
• W2896741434 hasAuthorship W2896741434A5086729495 @default.
• W2896741434 hasBestOaLocation W28967414341 @default.
• W2896741434 hasConcept C104317684 @default.
• W2896741434 hasConcept C123012128 @default.
• W2896741434 hasConcept C127561419 @default.
• W2896741434 hasConcept C140149449 @default.
• W2896741434 hasConcept C145059251 @default.
• W2896741434 hasConcept C1491633281 @default.
• W2896741434 hasConcept C153911025 @default.
• W2896741434 hasConcept C173396325 @default.
• W2896741434 hasConcept C185592680 @default.
• W2896741434 hasConcept C190283241 @default.
• W2896741434 hasConcept C202751555 @default.
• W2896741434 hasConcept C2777411675 @default.
• W2896741434 hasConcept C502942594 @default.
• W2896741434 hasConcept C54009773 @default.
• W2896741434 hasConcept C55493867 @default.
• W2896741434 hasConcept C75217442 @default.
• W2896741434 hasConcept C86803240 @default.
• W2896741434 hasConceptScore W2896741434C104317684 @default.
• W2896741434 hasConceptScore W2896741434C123012128 @default.
• W2896741434 hasConceptScore W2896741434C127561419 @default.
• W2896741434 hasConceptScore W2896741434C140149449 @default.
• W2896741434 hasConceptScore W2896741434C145059251 @default.
• W2896741434 hasConceptScore W2896741434C1491633281 @default.

• next