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• W2896744333 abstract "Clinical amyloid imaging has been approved by the Food and Drug Administration in the United States since 2012, but has been variably used by clinicians for a variety of reasons. Literature review and personal opinion. Amyloid is one of the two defining characteristics of Alzheimer's disease (AD), and our ability to image amyloid with PET has aided clinicians significantly. A new AD research framework has been proposed, defining AD by the presence of amyloid and tau through the use of biomarkers. However, while the FDA has approved the use of amyloid PET, the Center for Medicare and Medicaid Services does not cover reimbursement. As such, through the Coverage with Evidence Development procedure, the IDEAS study is underway to determine if amyloid imaging will affect the outcome of patients. Appropriate use criteria have been published to indicate when amyloid PET is appropriate. Clinical cases will be shown to demonstrate these circumstances. However, the clinical uptake of amyloid imaging in the United States has been slow. The cost of the scans is a limiting factor for clinicians and patients. In addition, the availability and distribution of the PET tracers by the manufacturers can be problematical. While the scans are specific for amyloid, the role of amyloid in clinical conditions vary While amyloid is likely the primary cause of cognitive impairment in familial AD, it is only one component in the causal pathway of older persons. For example, in cognitively impaired persons in their 70s or 80s, amyloid may be present but is likely only a part of the explanation of the underlying cognitive impairment, and the role of amyloid may be more difficult to interpret. Case examples will be shown of this issue. Amyloid imaging has been a major advancement in the field of aging and dementia. The IDEAS study will be important with respect to payment issues, and additional longitudinal data will be needed to determine the role of interpreting amyloid scans along the spectrum of cognition and aging." @default.
• W2896744333 created "2018-10-26" @default.
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• W2896744333 date "2018-07-01" @default.
• W2896744333 modified "2023-10-16" @default.
• W2896744333 title "FTS3‐01‐03: U.S. PERSPECTIVE ON CLINICAL AMYLOID IMAGING" @default.
• W2896744333 doi "https://doi.org/10.1016/j.jalz.2018.06.2758" @default.
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